Abstract
This study evaluated the antiscabies efficacy of 70% ethanol extracts from various parts of the mangrove Sonneratia alba (leaves, flowers, bark, and roots) as a potential alternative therapy. The primary objective was to compare the healing effects of the extracts at different concentrations on scabies lesions in mice (Mus musculus). Using a completely randomized design, 24 male Swiss Webster mice were assigned to four groups: a control (K0) group and three treatment groups to receive 10% (K1), 20% (K2), and 30% (K3) extract concentrations topically twice daily. The results demonstrated that the S. alba extracts had significant effects on lesion healing (p < 0.05). The leaf and root extracts exhibited optimal efficacy at a 10% concentration, whereas the bark and flower extracts were the most effective at 30% concentration. These findings suggest that S. alba extracts, particularly those from leaves and roots, hold significant promise as a novel plant-based treatment for scabies, warranting further research into their potential clinical applications.
Recommended Citation
Maretha, Delima Engga; Taresha, Lara Mukti; Yuliana, Karina; Ariska, Iis; and Lestari, Silvia Diah
(2026)
"Comparative Antiscabies Efficacy of Sonneratia alba Extracts: Evaluation of Plant Parts and Concentrations in Mice,"
Makara Journal of Science: Vol. 30:
Iss.
1, Article 6.
DOI: 10.7454/mss.v30i1.2744
Available at:
https://scholarhub.ui.ac.id/science/vol30/iss1/6
Included in
Botany Commons, Medical Pharmacology Commons, Medicinal and Pharmaceutical Chemistry Commons, Medicinal Chemistry and Pharmaceutics Commons, Natural Products Chemistry and Pharmacognosy Commons, Parasitic Diseases Commons, Pharmacology Commons, Skin and Connective Tissue Diseases Commons
