Development of an Environment-Friendly and Solvent-Free Synthetic Route for the Synthesis of 3,4-Dihydropyrimidin-2-(1H)-Ones/Thiones Using La(NO3)3.6H2O as an Efficient Catalyst

Authors

Farzaneh Mohamadpour, Young Researchers and Elite Club, Shiraz Branch, Islamic Azad University, Shiraz 37195, IranFollow

Abstract

We present a facile and environmentally friendly procedure for the synthesis of corresponding 3,4-dihydropyrimidin-2-(1H)-ones/thiones derivatives. The synthesis was achieved using aone-pot three-component Biginelli reaction among β-keto esters (methyl or ethyl acetoacetate), aromatic aldehyde (benzaldehyde derivatives), and urea or thiourea in the presence of lanthanum (III) nitrate hexahydrate (La(NO3)3.6H2O), as a highly efficient catalyst under solvent-free conditions. This protocol has numerous advantages: it isan inexpensive, non-toxic, simple reaction work-upcatalyst with a high atom-economy, and shows excellent yields with short reaction times.

Recommended Citation

Mohamadpour, Farzaneh (2018) "Development of an Environment-Friendly and Solvent-Free Synthetic Route for the Synthesis of 3,4-Dihydropyrimidin-2-(1H)-Ones/Thiones Using La(NO3)3.6H2O as an Efficient Catalyst," Makara Journal of Science: Vol. 22: Iss. 3, Article 6.
DOI: 10.7454/mss.v22i3.9899
Available at: https://scholarhub.ui.ac.id/science/vol22/iss3/6