Cytotoxic Triterpenoid from the Stembark of Chisocheton celebicus (Meliaceae)

Authors

Dewa Gede Katja, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Sam Ratulangi, Manado 95115, Indonesia
Kindi Farabi, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia
Desi Harneti, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia
Tri Mayanti, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia
Unang Supratman, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, IndonesiaFollow

Abstract

Plants belonging to the Chisocheton genus are a rich source of tetracylic triterpenoids with diverse biological activities. Two triterpenoid compounds,dammar-20,24-dien-3-one (1) and 3β-hydroxy-tirucall-7-en (2) were isolated from the stembark of Chisocheton celebicus. The chemical structures of compounds 1 and 2 were identified by spectroscopic data, including IR, NMR (1H, 13C, DEPT 135°, HMQC, HMBC, 1H-1H COSY), and MS, and they were compared with previously reported spectral data. Compounds 1 and 2 were evaluated for their cytotoxic effects against P-388 murineleukemia cells. The compounds showed cytotoxicity against P-388 murine leukemia cells, with IC50 values of 30.2 and 4.3 μg/mL, respectively.

Recommended Citation

Katja, Dewa Gede; Farabi, Kindi; Harneti, Desi; Mayanti, Tri; and Supratman, Unang (2017) "Cytotoxic Triterpenoid from the Stembark of Chisocheton celebicus (Meliaceae)," Makara Journal of Science: Vol. 21: Iss. 1, Article 2.
DOI: 10.7454/mss.v21i1.7531
Available at: https://scholarhub.ui.ac.id/science/vol21/iss1/2