Identification and Bioactivity Studies of Flavonoid Compounds from Macaranga hispida (Blume) Mull.Arg

Authors

Megawati, Research Center for Chemistry-LIPI, Region PUSPIPTEK Serpong, Banten 15314, IndonesiaFollow
Endang Saepudin, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok 16424, Indonesia
Muhammad Hanafi, Research Center for Chemistry-LIPI, Region PUSPIPTEK Serpong, Banten 15314, Indonesia
Akhmad Darmawan, Research Center for Chemistry-LIPI, Region PUSPIPTEK Serpong, Banten 15314, Indonesia
Puspa Dewi N. Lotulung, Research Center for Chemistry-LIPI, Region PUSPIPTEK Serpong, Banten 15314, Indonesia

Abstract

Two flavonoid compounds, 5,7,3’,4’-tetrahydroxy-6-geranylflavonol (1) and kaempferol 7-O-β-glucose (2) have been isolated from the leaves of Macaranga hispida (Blume), Mull.Arg. Isolation and purification were conducted by chromatography methods and chemical structure characterization was carried out by spectroscopic methods. The 5,7,3’,4’-tetrahydrxyi-6-geranyl flavonol (1) and kaempferol 7-O-glucose (2) had moderate cytotoxic activity against murine leukemia P-388 cell lines with IC50 value of 0.22 and 101.5 μg/mL, respectively. The IC50 for antioxidant activities of (1) and (2) were 2.83 and 13.95 μg/mL, respectively. The LC50 of (1) and (2) from BSLT were 350 and >1000 μg/mL, respectively.

Recommended Citation

Megawati; Saepudin, Endang; Hanafi, Muhammad; Darmawan, Akhmad; and Lotulung, Puspa Dewi N. (2015) "Identification and Bioactivity Studies of Flavonoid Compounds from Macaranga hispida (Blume) Mull.Arg," Makara Journal of Science: Vol. 19: Iss. 3, Article 2.
DOI: 10.7454/mss.v19i3.4848
Available at: https://scholarhub.ui.ac.id/science/vol19/iss3/2