Self-Assembly and Hydrogelation of Peptide Amphiphiles

Authors

Irwansyah Irwansyah, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok 16424, IndonesiaFollow
Riwandi Sihombing, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok 16424, Indonesia
Wahyudi Wahyudi Suwarso, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok 16424, Indonesia

Abstract

Seven peptide amphiphiles were successfully synthesized using solid phase peptide synthesis method. Peptide amphiphiles were characterized using Matrix-assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometer (MALDI-TOF MS). Atomic force microscopy (AFM) study showed that peptide amphiphiles having glycine, valine, or proline as linker, self-assembled into 100-200 nm nanofibers structure. According to our research, both peptide amphiphile with positive and negative charges bear similar self-assembly properties. Peptide amphiphile also showed its capability as low molecular weight gelator (LMWG). Peptide amphiphiles bearing C-16 and C-12 as alkyl showed better hydrogelation properties than C-8 alkyl. Five out of seven peptide amphiphiles have minimum gelation concentration (MGC) lower than 1% (w/v).

References

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Recommended Citation

Irwansyah, Irwansyah; Sihombing, Riwandi; and Suwarso, Wahyudi Wahyudi (2012) "Self-Assembly and Hydrogelation of Peptide Amphiphiles," Makara Journal of Science: Vol. 16: Iss. 1, Article 9.
DOI: 10.7454/mss.v16i1.1281
Available at: https://scholarhub.ui.ac.id/science/vol16/iss1/9