SYNTHESIZING DERIVATIVES FROM CYCLOPENTANONE ANALOGUE CURCUMIN AND THEIR TOXIC, ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES

Authors

Yum Eryanti, Organic Synthesize Laboratory, Department of Chemistry, University of Riau, Pekanbaru 28293, IndonesiaFollow
Yuana Nurulita, Biochemistry Laboratory, Department of Chemistry, University of Riau, Pekanbaru 28293, Indonesia
Rudi Hendra, Organic Synthesize Laboratory, Department of Chemistry, University of Riau, Pekanbaru 28293, Indonesia
Yuharmen Yuharmen, Organic Synthesize Laboratory, Department of Chemistry, University of Riau, Pekanbaru 28293, Indonesia
Jufrizal Syahri, Organic Synthesize Laboratory, Department of Chemistry, University of Riau, Pekanbaru 28293, Indonesia
Adel Zamri, Organic Synthesize Laboratory, Department of Chemistry, University of Riau, Pekanbaru 28293, Indonesia

Abstract

Three types of cyclopentanone derivatives have been synthesized from aromatic aldehyde and ketone derivatives under a base condition through aldol condensation. These cyclopentanone products were 2,5-dibenzylidene-cyclopentanone (a), 2,5-bis-(4-hydroxy-benzylidene)-cyclopentanone (b), and 2,5-bis-(4-hydroxy-benzylidene)-cyclopentanone (c) which has a yield of 63-99%. The chemical structure of these compounds were determined using UV, IR and NMR spectroscopy. In order to clarify the role of hydroxyl and amine moieties, toxic, antioxidant and anti-inflammatory activities were carried out. The toxic test indicated that the compounds showed strong toxicity. In addition, the presence of hydroxyl and amine groups on both rings of curcumin increased the antioxidant and anti-inflammatory activities.

References

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Recommended Citation

Eryanti, Yum; Nurulita, Yuana; Hendra, Rudi; Yuharmen, Yuharmen; Syahri, Jufrizal; and Zamri, Adel (2011) "SYNTHESIZING DERIVATIVES FROM CYCLOPENTANONE ANALOGUE CURCUMIN AND THEIR TOXIC, ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES," Makara Journal of Science: Vol. 15: Iss. 2, Article 20.
Available at: https://scholarhub.ui.ac.id/science/vol15/iss2/20