STUDI IN SILICO MODIFIKASI POS TRANSLASI DISAIN VAKSIN CHIMERIC BERBASIS VIRUS LIKE PARTICLES HUMAN PAPILLOMAVIRUS DENGAN KAPSID VIRION L1

Authors

Usman Sumo Friend Tambunan, Departemen Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Indonesia, Depok 16424, IndonesiaFollow
Arli Aditya Parikesit, Departemen Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Indonesia, Depok 16424, Indonesia
Theo A. Tochary, Departemen Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Indonesia, Depok 16424, Indonesia
Dedy Sugiono, Departemen Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Indonesia, Depok 16424, Indonesia

Abstract

Computational Study of Post Translation Modification in Chimeric Virus Like Particles Vaccine of Human Papilloma Virus with Virion Capsid L1. The Human Papillomavirus (HPV) infection has a tight correlation with the incidence of cervical cancer. Chimeric virus like particles (cVLP) has been developed as vaccine candidate for preventing cervical cancer. cVLPs are improvement of Virus Like Particles (VLP) by substituting the epitope of L1 HPV -18 and -52 protein to L1 HPV -16 protein. They are ANN1, ANN2, HMM1, and HMM2. The impact of post translation modification will be determined. Based on In Silico study, the dominant post translation modification is glycosylation

References

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Recommended Citation

Tambunan, Usman Sumo Friend; Parikesit, Arli Aditya; Tochary, Theo A.; and Sugiono, Dedy (2007) "STUDI IN SILICO MODIFIKASI POS TRANSLASI DISAIN VAKSIN CHIMERIC BERBASIS VIRUS LIKE PARTICLES HUMAN PAPILLOMAVIRUS DENGAN KAPSID VIRION L1," Makara Journal of Science: Vol. 11: Iss. 2, Article 15.
Available at: https://scholarhub.ui.ac.id/science/vol11/iss2/15