Network Pharmacology of a Decaffeinated Green Coffee–Turmeric Combination: Potential Therapeutic Activity against Hypertension and Diabetes Mellitus

Authors

• Feri Eko Hermanto, Division of Computational Biology, Faculty of Animal Science and Technology, Universitas Brawijaya, Malang 65145, IndonesiaFollow
• Mohammad Saifur Rohman, Cardiovascular Research Center, Universitas Brawijaya, Malang 65145, IndonesiaFollow
• Victor Alvianoes Guterez Hose, Cardiovascular Research Center, Universitas Brawijaya, Malang 65145, IndonesiaFollow
• Mifetika Lukitasari, Cardiovascular Research Center, Universitas Brawijaya, Malang 65145, IndonesiaFollow
• Dwi Adi Nugroho, Cardiovascular Research Center, Universitas Brawijaya, Malang 65145, IndonesiaFollow
• Nashi Widodo, Cardiovascular Research Center, Universitas Brawijaya, Malang 65145, IndonesiaFollow
• Inggita Kusumastuty, Cardiovascular Research Center, Universitas Brawijaya, Malang 65145, IndonesiaFollow

Abstract

Decaffeinated green coffee and turmeric are recognized for their protective effects against hypertension (HTN) and diabetes mellitus (DM). Combining them into a functional drink, green coffee and turmeric (GCT), offers potential health benefits for managing these conditions. This study explored the bioactivity of GCT in HTN and DM through network biology, identifying intersecting protein targets and their roles in inflammation and glucose metabolism. Key proteins identified were AKT1, CCL2, CXCL8, IL-1β, and IL18. Molecular docking revealed that GCT compounds, particularly Cafestol, Chlorogenic Acid, Kahweol, Curcumin, and Desmethoxycurcumin, interacted strongly with AKT1 at its allosteric site, potentially inhibiting its activity. However, the interactions with other proteins were weak or nonexistent. Molecular dynamics simulations further validated these findings, showing that Cafestol, Chlorogenic Acid, and Kahweol exhibited stable interactions with AKT1 under physiological conditions, while Curcumin was unstable and displaced from the binding site. These results suggest that the protective effects of GCT against HTN and DM are mediated through the inhibition of AKT1, influencing pathways related to inflammation and glucose metabolism

Recommended Citation

Hermanto, Feri Eko; Rohman, Mohammad Saifur; Hose, Victor Alvianoes Guterez; Lukitasari, Mifetika; Nugroho, Dwi Adi; Widodo, Nashi; and Kusumastuty, Inggita (2026) "Network Pharmacology of a Decaffeinated Green Coffee–Turmeric Combination: Potential Therapeutic Activity against Hypertension and Diabetes Mellitus," Makara Journal of Science: Vol. 30: Iss. 3, Article 14.
DOI: 10.7454/mss.v30i3.2852
Available at: https://scholarhub.ui.ac.id/science/vol30/iss3/14