Flavonoid Compounds from the Bark of Aglaia eximia (Meliaceae)

Authors

Julinton Sianturi, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, Indonesia
Mayshah Purnamasari, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, Indonesia
Tri Mayanti, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, Indonesia
Desi Harneti, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, Indonesia
Unang Supratman, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, IndonesiaFollow
Khalijah Awang, Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 59100, Malaysia
Hideo Hayashi, Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Gakuen-cho, Sakai, Osaka 599-8531, Japan

Abstract

Three flavonoid compounds, kaempferol (1), kaempferol-3-O-α-L-rhamnoside (2), and kaempferol-3-O-β-D-glucosyl-α-L-rhamnoside (3), were isolated from the bark of Aglaia eximia (Meliaceae). The chemical structures of compounds 1–3 were identified with spectroscopic data, including UV, IR, NMR (1H, 13C, DEPT 135°, HMQC, HMBC, 1H-1H-COSY NMR), and MS, as well as a compared with previously reported spectra data. All compounds were evaluated for their cytotoxic effects against P-388 murine leukemia cells. Compounds 1–3 showed cytotoxicity against P-388 murine leukemia cells with IC50 values of 1.22, 42.92, and >100 mg/mL, respectively

Recommended Citation

Sianturi, Julinton; Purnamasari, Mayshah; Mayanti, Tri; Harneti, Desi; Supratman, Unang; Awang, Khalijah; and Hayashi, Hideo (2015) "Flavonoid Compounds from the Bark of Aglaia eximia (Meliaceae)," Makara Journal of Science: Vol. 19: Iss. 1, Article 2.
DOI: 10.7454/mss.v19i1.4476
Available at: https://scholarhub.ui.ac.id/science/vol19/iss1/2