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Abstract

Background: Vitamin D is an essential fat-soluble vitamin that is required daily by the body. Deficiency in vitamin D is experienced by most of the world's population. Vitamin D plays a role in maintaining the skin barrier by regulating keratinocyte proliferation and differentiation, promoting filaggrin formation, and intraepidermal lipids.

Discussion: The vital role of vitamin D, non-compliance with supplement consumption, and poor nutritional status of adult patients and the elderly with deficiency and insufficiency of vitamin D encourage studies regarding vitamin D delivery via the transdermal route. The lipophilicity of vitamin D allows it to penetrate through the skin barrier.
Conclusion: Research indicates that topical application of vitamin D3 is not only safe but also effective in increasing serum vitamin D levels. Thus, topical delivery is a promising alternative method for providing vitamin D supplementation or as a therapeutic option for specific conditions that leads to improved skin hydration and serum vitamin D levels.

References

  1. Sadat-Ali M, Bubshait DA, Al-Turki HA, Al-Dakheel DA, Al-Olayani WS. Topical delivery of vitamin D3: A randomized controlled pilot study. Int J Biomed Sci. 2014;10(1):21–4.
  2. Wyon MA, Wolman R, Martin C, Galloway S. The efficacy of different vitamin D supplementation delivery methods on serum 25(OH)D: A randomised double-blind placebo trial. Clin Nutr. 2021;40(2):388–93.
  3. Bubshait DA, Al-Dakheel DA, Alanii FM. Topical vitamin D3: A randomized controlled trial (RCT). Clin Nutr ESPEN. 2018;27:16–9.
  4. Glowka E, Stasiak J, Lulek J. Drug delivery systems for vitamin D supplementation and therapy. Pharmaceutics. 2019;11(7):347.
  5. Mostafa WZ, Hegazy RA. Vitamin D and the skin: Focus on a complex relationship: A review. J Adv Res. 2014;6(6):793–804.
  6. Bikle DD. Vitamin D: Production, metabolism and mechanisms of action [Internet]. South Dartmouth: National Library of Medicine; 2021. [reviewed 2021 Dec 31; cited 2024 Apr 21]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK278935/.
  7. Chen Q, Liu L, Zhang Y. Vitamin D and wound healing: Assessing skin barrier function and implications for chloasma treatment. Int Wound J. 2024;21(1):19–20.
  8. Kim B, Cho H-E, Moon SH, et al. Transdermal delivery systems in cosmetics. Biomed Dermatol. 2020;4(1):1–12.
  9. Sawarkar S, Ashtekar A. Transdermal vitamin D supplementation—A potential vitamin D deficiency treatment. J Cosmet Dermatol. 2020;19(1):28–32.
  10. Wooi Ng K, Lau WM. Skin deep: The basics of human skin structure and drug penetration. In: Dragicevic N, Maibach H, editors. Percutaneous penetration enhancers chemical methods in penetration enhancement: Drug manipulation strategies and vehicle effects. Berlin, Heidelberg: Springer Berlin Heidelberg; 2015. p. 3–11.
  11. Tončić RJ, Kezić S, Hadžavdić SL, Marinović B. Skin barrier and dry skin in the mature patient. Clin Dermatol. 2018;36(2):109–15.
  12. Kubo A, Amagai M. Percutaneous absorption through the stratum corneum. In: Kang S, Amagai M, Brucker AL, et al. editors. Fitzpatrick’s Dermatology 9th Edition. 9th ed. New York: McGraw-Hill; 2019. p. 217.
  13. Alkilani AZ, McCrudden MTC, Donnelly RF. Transdermal drug delivery: Innovative pharmaceutical developments based on disruption of the barrier properties of the stratum corneum. Pharmaceutics. 2015;7(4):438–70.
  14. Ali S, Shabbir M, Shahid N. The structure of skin and transdermal drug delivery system - a review. Research J Pharm and Tech. 2015;8(2):103–9.
  15. Vitorino C, Sousa J, Pais A. Overcoming the skin permeation barrier: Challenges and opportunities. Curr Pharm Des. 2015;21(20):2698–712.
  16. Neupane R, Boddu SHS, Abou-Dahech MS, et al. Transdermal delivery of chemotherapeutics: Strategies, requirements, and opportunities. Pharmaceutics. 2021;13(7):1–32.
  17. Soni A, Dua JS, Prasad DN. Article reviewing transdermal drug delivery system. Journal of Drug Delivery and Therapeutic. 2022;12(1):176–80.
  18. Jeong WY, Kwon M, Choi HE, Kim KS. Recent advances in transdermal drug delivery

    systems: A review. Biomater Res. 2021;25(1):1–15.
  19. Piotrowska A, Wierzbicka J, Zmijewski MA. Vitamin D in the skin physiology and pathology. Acta Biochim Pol. 2016;63(2):1–13.
  20. Umar M, Sastry KS, Al Ali F, Al-Khulaifi M, Wang E, Chouchane AI. Vitamin D and the pathophysiology of inflammatory skin diseases. Skin Pharmacol Physiol. 2018;31(2):74–86.
  21. Umehara Y, Trujillo-Paez JV, Yue H, et al. Calcitriol, an active form of vitamin D3, mitigates skin barrier dysfunction in atopic dermatitis NC/Nga Mice. Int J Mol Sci. 2023;24(11):9347.
  22. Alsaqr A, Rasoully M, Musteata FM. Investigating transdermal delivery of vitamin D3. AAPS PharmSciTech. 2015;16(4):963–72.
  23. Costa GMD, Pinto CASO, Leite-Silva VR, Baby AR, Velasco MVR. Is vitamin D3 transdermal formulation feasible? An ex vivo skin retention and permeation. AAPS PharmSciTech. 2018;19(5):2418–25.
  24. Jefferson A, Borges C. Evaluation of the safety, tolerability and plasma vitamin D response to long-term use of patented transdermal vitamin D patches in healthy adults: A randomised parallel pilot study. BMJ Nutr Prev Heal. 2022;5(2):217–26.
  25. Ramezanli T, Kilfoyle BE, Zhang Z, Michniak-Kohn BB. Polymeric nanospheres for topical delivery of vitamin D3. Int J Pharm. 2017;516(1–2):196–203.

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