"Determinan Faktor dengan Ketidakpatuhan dalam Mengonsumsi Obat Antire" by DESSI MARANTIKA NILAM SARI, Mondastri Korib Sudaryo et al.
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Abstract

Ketidakpatuhan alasan utama Pasien HIV tidak menerima pengobatan ARV sehingga harus selalu dipantau dan dinilai secara teratur serta didorong pada setiap kunjungan. Penelitian ini bertujuan untuk mengamati determinan faktor terjadinya ketidakpatuhan dalam mengonsumsi obat ARV pada ODHIV yang mendapatkan terapi ARV di Rumah Sakit Umum Daerah Kabupaten Tangerang. Jenis penelitian ini menggunakan penelitian observasional dengan rancangan cross sectional. Penelitian dilakukan di poli HIV RSUD Kabupaten pada bulan November 2023 menggunakan data laporan HIV pada SIHA. Populasi penelitian berjumlah 1.337 ODHIV aktif menjalani pengobatan antiretroviral di RSUD Kabupaten Tangerang dengan menggunakan total sampling sesuai dengan kriteria inklusi dan ekslusi sehingga sampel penelitian berjumlah 1.286 ODHIV. Metode analisis data menggunakan cox regression dengan aplikasi STATA. Hasil analisis univariat menunjukan bahwa 88% studi populasi masuk dalam populasi kunci. Didapatkan faktor dominan yang berpengaruh terhadap ketidakpatuhan minum obat ARV adalah: variabel umur (PR 1,20 dengan 95% CI 1,05-1,38), status perkawinan (PR 1,18 dengan 95% CI 1,03-1,36), domisili (PR 1,19 dengan 95% CI 1,04-1,36), viral load (PR 1,27 dengan 95% CI 1,10-1,43), lamanya pengobatan (PR 1,25 dengan 95% CI 1,07-1,47), kelompok populasi kunci (PR 1,27 dengan 95% CI 1,04-1,56) dan dukungan teman sebaya (PR 1,15 dengan 95% 1,00-1,32). Hasil penelitian ini diharapkan menjadi acuan bagi RSUD dan Dinas Kesehatan Kabupaten Tangerang dalam meningkatkan penanganan HIV/AIDS, melalui edukasi dan motivasi kepatuhan ARV yang didukung keluarga, PMO, dan teman sebaya. Selain itu, perlu pengembangan SIM RS yang fleksibel serta standarisasi pencatatan dan pelaporan untuk optimalisasi pemantauan pasien.

References

1. UNAIDS. In Danger:UNAIDS Global AIDS Update 2022. UNAIDS Global AIDS Updat 2022 [Internet]. 2022;376. Available from: https://aidsinfo.unaids.org

2. Kemenkes. LAPORAN TAHUNAN HIV AIDS 2022. 2022;89-90.

3. Kemenkes. Data Kemenkes HIV. Kebijak Penanggulangan HIV/AIDS dan PIMS. 2022;1–19.

4. Marantika D, Sudaryo M K, et al. Faktor-faktor yang Berhubungan dengan Ketidakpatuhan Minum Antiretroviral pada Orang dengan HIV di Rumah Sakit Umum Daerah Balaraja Kabupaten Tangerang. 2023;7(2).

5. Kemenkes. Rencana Aksi Nasional Pencegahan dan Pengendalian HIV AIDS dan PIMS di Indones Tahun 2020-2024 [Internet]. 2020;1–188. Available from: https://hivaids-pimsindonesia.or.id/download/file/RAN_AIDS_2024.pdf

6. Kemenkes. Penanggulangan Human Immunodeficiency Virus, Acquired Immunodeficiency Syndrome, dan Infeksi Menular Seksual. Peraturan Menteri Kesehatan Republik Indonesia No 23 tahun 2022. 2022;(8.5.2017):2003–5.

7. WHO. Adherence to Long-Termtherapies World Health Organization:Evidance Action [Internet]. Vols. 1–194. 2003. Available from: https://apps.who.int/iris/bitstream/handle/10665/42682/9241545992.pdf?sequence=1

8. Nasir, A, Muhith, A I. Metode Penelitian Kesehatan. 1st ed. Yogyakarta: Mulia Medika; 2011. 54 p.

9. Kemenkes. Petunjuk Teknis Pengisian Format Pencatatan dan Pelaporan Pasien HIV/ AIDS Revisi dari tahun 2006 Kementerian Kesehatan RI. 2015;

10. Klouman E, Bhandari A, Ahmed LA. Factors Associated with Adherence to Antiretroviral Therapy in HIV-Infected Patients in Kathmandu District , Nepal. 2014;109–16.

11. Afrashteh S, Shokoohi M, Gheibi Z, Fararouei M. Non-adherence to Antiretroviral Treatment and Associated Factors Among People Living with HIV in Iran : a Retrospective cohort study. 2023;22(2).

12. Rajesh R, Sudha V, Dm V, Sonika S. Association Between Medication Adherence Outcomes and Adverse Drug Reactions to Highly Active Antiretroviral Therapy in Indian Human Immunodeficiency Virus-Positive Patients. 2012;4(4).

13. Denardo D, Mojola SA, Schatz E, Gómez-Olivé FX. Antiretroviral Therapy and Aging as Resources for Managing and Resisting HIV-Related Stigma in Rural South Africa. SSM - Qual Res Heal. 2022 Dec 1;2:100148.

14. Wang J, Wang G, Zhu X, Li L, Kang D. The care Status and Factors Affecting Antiretroviral Therapy Timing for People Living with HIV : a Retrospective Cohort study in Shandong Province , China. 2023; Available from: https://doi.org/10.1080/09540121.2023.2185197

15. Ubra R. Faktor – Faktor Yang Berhubungan Dengan Pada Pasien HIV Di Kabupaten Mimika - Provinsi Papua. 2012;1–136.

16. Tanyi WN, Gachuno O, Odero T, Farquhar C, Kimosop D, Mayi A. Factors Affecting Adherence to Antiretroviral Therapy Among Children and Adolescents Living with HIV in the Mbita Sub-County Hospital , Homa Bay- Kenya. 2021;21:18–24.

17. Auliannissa S, Bustamam N, Ningsih, Rahayu S. The Adherence to Fixed-Dose Combination Antiretroviral Therapy and Viral Load in HIV Patients. 2020;20(1):21–6.

18. Auliannissa S. Antiretroviral Fixed Dose Combination Terhadap Viral Load Pada ODHA Di Rumah Sakit Pengayoman Cipinang Pada Tahun 2015-2018. 2018;0–1.

19. Neupane S, Dhungana GP, Ghimire HC. Adherence to Antiretroviral Treatment and Associated Factors Among People Living with HIV and AIDS in Chitwan , Nepal. 2019;1–9.

20. Monasel AH, Susanto HS, Yuliawati S, Sutiningsih D. Faktor-Faktor yang Berhubungan dengan Kualitas Hidup Orang dengan HIV/AIDS (ODHA) di Yayasan Sehat Peduli Kasih, Kota Semarang. Jurnal Epidemiologi Kesehatan Komunitas. 2022;7(1):444–57.

21. Tarkang EE, Manu E, Aku FY, Anaman-Torgbor J, Khuzwayo N. Sociodemographic and health systems determinants of antiretroviral therapy adherence among human immunodeficiency virus-positive patients in the Volta Region of Ghana: A multi-centre study. SAGE Open Med. 2024;12.

22. Rohman, Ramadhantie. Analisa Faktor yang Mempengaruhi Kepatuhan Menjalani Terapi Antiretroviral Pada ODHA. 2021.

23. Widyaningrum N. Pengaruh Efek Samping Obat Antiretroviral Lini Pertama terhadap Kepatuhan Pengobatan Pasien HIV/AIDS di RSPI Prof Dr Sulianti Saroso Tahun 2010-2015. Univ Indones. 2016;

24. Rosamond E, Weaver N, Pane M, Wandra T, Windiyaningsih C. Factors that Influence Adherence to Antiretroviral Treatment in an Urban Population , Jakarta , Indonesia. 2014;9(9):1–7.

Bahasa Abstract

Non-adherence is the main reason why HIV patients fail to receive antiretroviral (ARV) treatment, thus requiring continuous monitoring, assessment, and encouragement during every visit. This study aimed to examine the determinants of non-adherence to ARV medication among people living with HIV (PLHIV) receiving ARV therapy at the Regional General Hospital (RSUD) of Tangerang Regency. This was an observational study using a cross-sectional design. The research was conducted at the HIV clinic of RSUD Tangerang in November 2023 using secondary data from the HIV report in the SIHA system. The study population consisted of 1,337 PLHIV actively undergoing ARV treatment, with a final sample of 1,286 PLHIV selected using total sampling based on inclusion and exclusion criteria. Data analysis was performed using Cox regression in STATA. Univariate analysis showed that 88% of the study population belonged to key population groups. The dominant factors associated with ARV non-adherence were: age (PR 1.20; 95% CI: 1.05–1.38), marital status (PR 1.18; 95% CI: 1.03–1.36), domicile (PR 1.19; 95% CI: 1.04–1.36), viral load (PR 1.27; 95% CI: 1.10–1.43), duration of treatment (PR 1.25; 95% CI: 1.07–1.47), key population group (PR 1.27; 95% CI: 1.04–1.56), and peer support (PR 1.15; 95% CI: 1.00–1.32). The findings of this study are expected to serve as a reference for RSUD and the Tangerang District Health Office in strengthening HIV/AIDS management, particularly in providing education and motivation to improve ARV adherence, supported by families, treatment supporters (PMOs), and peer groups. Additionally, a more flexible hospital information system and standardized patient recording and reporting are needed to optimize monitoring efforts.

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