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Herwinda Brahmanti, Department of Dermatology and Venereology, Dr. Saiful Anwar Regional General Hospital/ Faculty of Medicine, Universitas Brawijaya, Jl. Mayjen Haryono 169, Malang, East Java, 65145, Indonesia
Arif Widiatmoko, Department of Dermatology and Venereology, Dr. Saiful Anwar Regional General Hospital/ Faculty of Medicine, Universitas Brawijaya, Jl. Mayjen Haryono 169, Malang, East Java, 65145, Indonesia
Dhelya Widasmara, Department of Dermatology and Venereology, Dr. Saiful Anwar Regional General Hospital/ Faculty of Medicine, Universitas Brawijaya, Jl. Mayjen Haryono 169, Malang, East Java, 65145, Indonesia
Diane Tantia Sari, Department of Dermatology and Venereology, Dr. Saiful Anwar Regional General Hospital/ Faculty of Medicine, Universitas Brawijaya, Jl. Mayjen Haryono 169, Malang, East Java, 65145, IndonesiaFollow
Shahdevi Nandar Kurniawan, Department of Neurology, Dr. Saiful Anwar Regional General Hospital/ Faculty of Medicine, Universitas Brawijaya, Jl. Mayjen Haryono 169, Malang, East Java, 65145, Indonesia
Widodo Mardi Santoso, Department of Neurology, Dr. Saiful Anwar Regional General Hospital/ Faculty of Medicine, Universitas Brawijaya, Jl. Mayjen Haryono 169, Malang, East Java, 65145, Indonesia
Ristiawan Muji Laksono, Department of Anestesiology and Reanimation, Dr. Saiful Anwar Regional General Hospital/ Faculty of Medicine, Universitas Brawijaya, Jl. Mayjen Haryono 169, Malang, East Java, 65145, Indonesia
Abdul Gofur, Department of Neurology, Dr. Saiful Anwar Regional General Hospital/ Faculty of Medicine, Universitas Brawijaya, Jl. Mayjen Haryono 169, Malang, East Java, 65145, Indonesia

Abstract

Background: Sensory nerve damage is the earliest leprosy sign which can lead to disability. Previous studies showed that autologous platelet-rich plasma (PRP) perineural blind injection can stimulate leprosy sensory nerve regeneration. Our study provided a safer and more accurate PRP agent delivery method through ultrasound-guided injection and was the first to compare PRP versus standard neuropathy treatment, the neurotropic vitamin. This study aimed to determine the effectiveness of combination therapy of ultrasound-guided PRP perineural injection and oral vitamin B complex compared to single oral vitamin B complex in sensory peripheral neuropathy of posterior tibial nerve in leprosy patients.

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