Abstract
Introduction. Breast cancer is still one of the top health issues worldwide. Hereditary predisposition is linked with morbidity and mortality of breast cancer patients. BRCA 1/2 genetic mutation, one of mutations in breast cancer that has been extensively observed, has tremendous effects on the carrier. Studies showed that patients with BRCA1/2 mutation are often associated with poor pathological characteristics. Further research isyet to identify the effect of the mutation with prognosis including locoregional recurrences. This study aims to understand the risk of locoregional recurrences on the patients with breast cancer and BRCA 1/2 genetic mutation who had BCT or mastectomy.
Method. Comprehensive literature search conducted based on clinical-questions-related keywords from various sites i.e., Cochrane, PubMed, EBSCOhost, ProQuest, and ScienceDirect. Three articles were selected considering the exclusions and inclusions criteria. Later the articles were critically appraised based on validity, importance, and applicability.
Results. Two of the three articles showed no statistical difference on the locoregional recurrence on the patients with the breast cancer and the BRCA1/2 genetic mutation who had BCT and mastectomy. The locoregional recurrence was 0 – 8.1% in patients underwent BCT. Whilst the patient underwent mastectomy had 3.5 – 22.2% locoregional recurrence with p value < 0.05.
Conclusion. BCT can be considered as a locoregional treatment in breast cancer with BRCA 1/2 genetic mutation as it is equally effective as mastectomy because both had negligible differences in locoregional recurrences.
Recommended Citation
Karisyah, Adlina and Panigoro, Sonar S.
(2026)
"Locoregional Management in Breast Cancer with BRCA1/2 Mutation: Evidence Based Case Report,"
The New Ropanasuri Journal of Surgery: Vol. 10:
No.
1, Article 4.
DOI: 10.7454/nrjs.v10i1.1187
Available at:
https://scholarhub.ui.ac.id/nrjs/vol10/iss1/4
