Introduction. Locally advanced breast cancer is a quite common clinical scenario in the developing countries where the recurrence remains a problem. Mastectomy is one of the primary treatment. Age, clinical stage, lymph nodes involvement, histopathlogy, tumorgrading and itssubtypes are thought as clinic histopathologic factors influencing the recurrence. We run a study aimed to find out role of these factors on the recurrence after mastectomy. Method. The study designed as an analytical cross–sectional one. A complete data of all patients treated in dr. Cipto Mangunkusumo General Hospital with locally advanced breast cancer underwentmastectomy withappropriate definitive treatmenttothe stage, and had disease free interval, and could be followed for at least 24 months during period of January 2011 to December 2012 is recorded. Results. There were 39 subjects enrolled. Among these subjects, the recurrence was 7.6%. Through bivariate analysis we found a significant correlation between the histopathology type (p = 0.008), lymph nodes involvement (p = 0.026) with the recurrence. In multivariate analysis we found that the most influential factor to reccurrence was lymph node involvement (p = 0.002). Conclusion. In this study the most influential factor on the recurrence in locally advanced breast cancer following mastectomy is positive lymph nodes more than three nodes.



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