Abstract

Leptospirosis is a tropical endemic disease that can reduce the productivity of sufferers. However, research on economic and productivity losses due to leptospirosis is rare. This study aimed to determine economic and productivity losses due to leptospirosis in the Banyumas District, Indonesia, as an endemic area. This study used a cross-sectional design and quantitative methods conducted in October 2022. Secondary data of medical records and billing information from 73 inpatients receiving treatment at a Public Hospital in the Banyumas District from February 2021 to September 2022 obtained from the hospital’s archives were used. This study examined the actual costs (direct and indirect costs) of treatment, average length of stay, and patient characteristics. Statistical tools were carried out to check the results. The results showed that over half of leptospirosis patients used insurance with an economic loss of USD 289.64 and a productivity loss value of USD 388,499. Patients infected with leptospirosis vary in age. Leptospirosis results in loss of patient productivity during treatment. Increasing prevention and control to prevent deaths and economic burdens on society and local governments is proposed to local governments.

References

1. Jumper WI. Infectious Agents : Leptospirosis. In: M.Hopper R. 2nd Ed. New York: John Wiley & Sons; 2021. p. 733–41. DOI: 10.1002/9781119602484.ch59.

2. Cilia G, Bertelloni F, Albini S, et al. Insight into the Epidemiology of Leptospirosis: A Review of Leptospira Isolations from "Unconventional" Hosts. Animals (Basel). 2021; 11 (1): 191. DOI: 10.3390/ani11010191.

3. Guglielmini J, Bourhy P, Schiettekatte O, et al. Genus-wide Leptospira core genome multilocus sequence typing for strain taxonomy and global surveillance. PLoS Negl Trop Dis. 2019; 13 (4): e0007374. DOI: 10.1371/journal.pntd.0007374.

4. Santos AAN, Ribeiro PDS, da França GV, et al. Leptospira Interrogans Biofilm Formation in Rattus Norvegicus (Norway Rats) Natural Reservoirs. PLoS Negl Trop Dis. 2021; 15 (9): 1–16. DOI: 10.1371/journal.pntd.0009736.

5. Mulyono A, Ristiyanto R, Pujiyanti A, et al. Catatan Baru Kelelawar Pemakan Nektar (Macroglossus Sobrinus) sebagai Reservoir Leptospirosis dari Indonesia. Vektora J Vektor Reserv Penyakit. 2018; 10 (2): 103–10. DOI: 10.22435/vk.v10i2.581.

6. Kementerian Kesehatan Republik Indonesia. Petunjuk Teknik Pengendalian Leptospirosis. Jakarta: Kementerian Kesehatan Republik Indonesia; 2017.

7. Diaz EA, Luna L, Burgos-Mayorga A, et al. First detection of Leptospira santarosai in the reproductive track of a boar: A potential threat to swine production and public health. PLoS One. 2022; 17 (9): e0274362. DOI: 10.1371/journal.pone.0274362.

8. Agampodi S, Gunarathna S, Lee J-S, et al. Global, regional, and country-level cost of leptospirosis due to loss of productivity in humans. medRxiv; 2023.

9. Sanhueza JM, Baker MG, Benschop J, et al. Estimation of the burden of leptospirosis in New Zealand. Zoonoses Public Health. 2020; 67 (2): 167– 176. DOI: 10.1111/zph.12668.

10. Dhewantara PW, Mamun AA, Zhang WY, et al. Epidemiological shift and geographical heterogeneity in the burden of leptospirosis in China. Infect Dis Poverty. 2018; 7 (1): 57. DOI: 10.1186/s40249-018-0435-2.

11. Hanifah LN. Cost of Illness Perawatan Pasien Leptospirosis di Instalasi Rawat Inap Rsud K.R.M.T Wongsonegoro Kota Semarang [Undergraduate Thesis]. Semarang: STI Farmasi Nusapetra; 2021.

12. Ristiyanto R, Handayani FD, Mulyono A, et al. Leptospirosis Case Finding for Development of Leptospirosis Surveillance in Semarang City, Central Java, Indonesia. Vektora J Vektor Reserv Penyakit. 2018; 10 (2): 111–116. DOI: 10.22435/vk.v10i2.284.

13. Kementerian Kesehatan Republik Indonesia. Profil Kesehatan Indonesia 2020. Jakarta: Kementerian Kesehatan Republik Indonesia; 2021.

14. Sembiring E. Diagnostic approach in leptospirosis patients. In: IOP Conf Ser Earth Environ Sci. 2018; 125 (1): 012089. DOI: 10.1088/1755- 1315/125/1/012089.

15. Md-Lasim A, Mohd-Taib FS, Abdul-Halim M, et al. Leptospirosis and Coinfection: Should We Be Concerned? Int J Environ Res Public Health. 2021; 18 (17): 9411. DOI: 10.3390/ijerph18179411.

16. Kementerian Kesehatan Republik Indonesia. Profil Kesehatan Indonesia 2021. Jakarta: Kementerian Kesehatan Republik Indonesia; 2022.

17. Galan DI, Roess AA, Pereira SVC, et al. Epidemiology of human leptospirosis in urban and rural areas of Brazil, 2000-2015. PLoS One. 2021; 16 (3): e0247763. DOI: 10.1371/journal.pone.0247763.

18. Naing C, Reid SA, Aye SN, et al. Risk factors for human leptospirosis following flooding: A meta-analysis of observational studies. PLoS One. 2019; 14 (5): e0217643. DOI: 10.1371/journal.pone.0217643.

19. Boey K, Shiokawa K, Rajeev S. Leptospira infection in rats: A literature review of global prevalence and distribution. PLoS Negl Trop Dis. 2019; 13 (8): e0007499. DOI: 10.1371/journal.pntd.0007499.

20. Badan Pusat Statistik (BPS). Kabupaten Banyumas dalam Angka 2021. Banyumas: Badan Pusat Statistik Kabupaten Banyumas; 2021.

21. Hacker KP, Sacramento GA, Cruz JS, et al. Influence of Rainfall on Leptospira Infection and Disease in a Tropical Urban Setting. Emerg Infect Dis. 2020; 26 (2): 311-314. DOI: 10.3201/eid2602.190102.

22. Chadsuthi S, Chalvet-Monfray K, Wiratsudakul A, et al. The effects of flooding and weather conditions on leptospirosis transmission in Thailand. Sci Rep. 2021; 11: 1486. DOI: 10.1038/s41598-020-79546-x.

23. Rajapakse S. Leptospirosis: Clinical aspects. Clin Med (Lond). 2022; 22 (1): 14-17. DOI: 10.7861/clinmed.2021-0784.

24. Gancheva GI. Cost Effectiveness of Predicting Severity in Leptospirosis. Int J Health Econ Policy. 2016; 1 (1): 20–25. DOI: 10.11648/j.hep.20160101.14.

25. Gancheva G. Prognostic Score for Severity of Leptospirosis. J IMAB. 2022; 28 (2): 4423–30. DOI: 10.5272/jimab.2022282.4423.

26. Bryan-Thomas J, Collins K, Omoregie J, et al. What is the Cost of Leptospirosis treatment in Jamaica? A Cross-sectional Study. Am J Public Health Res. 2018; 6 (3): 166–172. DOI: :10.12691/ajphr-6-3-7.

27. Pemerintah Daerah Kabupaten Banyumas. Laporan Keuangan Pemerintah Daerah Kabupaten Banyumas 2021. Banyumas: Pemerintah Daerah Kabupaten Banyumas; 2021.

28. Bupati Banyumas. Peraturan Daerah Nomor 14 Tahun 2021 Tentang Penyelenggaraan Satu Data Kabupaten Banyumas. Banyumas: Pemerintah Daerah Kabupaten Banyumas; 2021.

29. Pereira C, Barata M, Trigo A. Social cost of leptospirosis cases attributed to the 2011 disaster striking Nova Friburgo, Brazil. Int J Environ Res Public Health. 2014; 11 (4): 4140–4157. DOI: 10.3390/ijerph110404140.

30. Prahlad SR, Baxi RK, Godara N. Out-of-Pocket Expenditure and Opportunity Cost of Leptospirosis Patients at a Tertiary Care Hospital of Gujarat, India. Indian J Community Med. 2020; 45 (3): 363-366. DOI: 10.4103/ijcm.IJCM_164_19.

31. Calvopiña M, Vásconez E, Coral-Almeida M, et al. Leptospirosis: Morbidity, mortality, and spatial distribution of hospitalized cases in Ecuador. A nationwide study 2000-2020. PLoS Negl Trop Dis. 2022; 16 (5): e0010430. DOI: 10.1371/journal.pntd.0010430.

32. Costa F, Hagan JE, Calcagno J, et al. Global Morbidity and Mortality of Leptospirosis: A Systematic Review. PLoS Negl Trop Dis. 2015; 9 (9): e0003898. DOI: 10.1371/journal.pntd.0003898.

33. Gasem MH, Hadi U, Alisjahbana B, et al. Leptospirosis in Indonesia: Diagnostic challenges associated with atypical clinical manifestations and limited laboratory capacity. BMC Infect Dis. 2020; 20 (1): 179. DOI: 10.1186/s12879-020-4903-5.

34. Karpagam KB, Ganesh B. Leptospirosis: A neglected tropical zoonotic infection of public health importance—an updated review. Eur J Clin Microbiol Infect Dis. 2020; 39 (5): 835–846. DOI: 10.1007/s10096-019-03797-4.

35. Permatawati NA. Leptospirosis Surveillance System Readiness in the Banyumas District (A Case Study in the Banyumas District Using a Qualitative Approach, 2015). In: The 2nd Int Meeting Public Health (IMOPH) KnE Life Sci. 2018; 4 (4): 216-222. DOI: 10.18502/kls.v4i4.2280.

36. Munoz-Zanzi C, Groene E, Morawski BM, et al. A systematic literature review of leptospirosis outbreaks worldwide, 1970-2012. Rev Panam Salud Publica. 2020; 44: e78. DOI: 10.26633/RPSP.2020.78.

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