Abstract

Ambient air pollution, especially from fine particles, contributes to human mortality from cardiovascular and respiratory diseases, for which high blood pressure (BP) is a major modifiable risk factor. This study aimed to analyze the influence of ambient particulate matter (PM2.5) on the risk of high BP leading to hypertension. This study used a cross-sectional design on 118 adult women living in Central Jakarta, Indonesia. Participants were selected from a 1-km radius of the nearest air quality monitoring station with available data PM2.5. Linear regression was analyzed to examine the relationship between PM2.5 and systolic and diastolic BPs adjusted for potential confounders. The annual means of PM2.5 concentration was 36±5.74 μg/m3. The linear regression model showed that PM2.5 exposure was associated with systolic BP after controlling with age and body mass index (r = 0.408; R2 = 0.167). The second model showed that exposure to PM2.5 concentration could explain about 10.9% variation of diastolic BP after controlling with age, length of stay, body mass index, smoking status, and diabetes mellitus record. Ambient air PM2.5 has a risk of BP and hypertension among adult women in Central Jakarta.

References

1. Stanaway JD, Afshin A, Gakidou E, et al. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: A systematic analysis for The Global Burden of Disease Study 2017. Lancet. 2018; 392 (10159): 1923-1994. DOI: 10.1016/S0140-6736(18)32225-6.

2. Oparil S, Acelajado MC, Bakris GL, et al. Hypertension. Nature Rev Dis Primers. 2018; 4: 1-21. DOI: 10.1038/nrdp.2018.14.

3. World Health Organization. Hypertension. Geneva: World Health Organization; 2021.

4. Badan Penelitian dan Pengembangan Kesehatan. Hasil Utama Riskesdas 2018. Jakarta: Kementerian Kesehatan Republik Indonesia; 2018.

5. Curto A, Wellenius GA, Milà C, et al. Ambient particulate air pollution and blood pressure in peri-urban India. Epidemiol. 2019; 30 (4): 492-500. DOI: 10.1097/EDE.0000000000001027.

6. Bo Y, Guo C, Lin C, et al. Dynamic changes in long-term exposure to ambient particulate matter and incidence of hypertension in adults: A natural experiment. Hypertension. 2019; 74 (3): 669-677. DOI: 10.1161/HYPERTENSIONAHA.119.13212.

7. Centers for Disease Control and Prevention. Air quality: Air pollutants. Atlanta, GA: Centers for Disease Control and Prevention; 2021.

8. Li N, Chen G, Liu F, et al. Associations between long-term exposure to air pollution and blood pressure and effect modifications by behavioral factors. Environ Res. 2020; 182: 109109. DOI: 10.1016/j.envres.2019.109109.

9. IQ Air. 2020 World Air Quality Report Region & City PM2.5 Ranking. Goldach: IQ Air; 2020.

10. Zhang Z, Dong B, Li S, et al. Exposure to ambient particulate matter air pollution, blood pressure and hypertension in children and adolescents: A national cross-sectional study in China. Environ Int. 2019; 128: 103-108. DOI: 10.1016/j.envint.2019.04.036.

11. Liang F, Liu F, Chen J, et al. Long-term exposure to fine particulate matter and hypertension incidence in China: The China-PAR cohort study. Hypertension. 2019; 73: 1195-1201. DOI: 10.1161/HYPERTENSIONAHA.119.12666.

12. Verma MK, Jaiswal A, Sharma P, et al. Oxidative stress and biomarker of TNF-α, MDA and FRAP in hypertension. J Med Life. 2019; 12 (3): 253- 259. DOI: 10.25122/jml-2019-0031.

13. Yekti R, Bukhari A, Jafar N, et al. Measurement of malondialdehyde (MDA) as a good indicator of lipid peroxidation. Int J Allied Med Sci Clin Res. 2020; 6 (4): 838-840. DOI: 10.61096/ijamscr.v6.iss4.2018.838-840.

14. Lemeshow S, Hosmer DW Jr, Klar J, et al. Adequacy of sample size in health studies. Chichester: John Wiley & Sons; 1990. Published on behalf of the World Health Organization. ISBN: 0-471-92517-9.

15. National High Blood Pressure Education Program. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Bethesda (MD): National Heart, Lung, and Blood Institute (US); 2004.

16. Cao H, Li B, Liu K, et al. Association of long-term exposure to ambient particulate pollution with stage 1 hypertension defined by the 2017 ACC/AHA Hypertension Guideline and cardiovascular disease: The CHCN-BTH cohort study. Environ Res. 2021; 199: 111356. DOI: 10.1016/j.envres.2021.111356.

17. Bantas K, Gayatri D. Gender and hypertension (data analysis of the Indonesia Basic Health Research 2007). J Epidemiol Kesehat Indonesia. 2019; 3 (1): 7-17. DOI: 10.7454/epidkes.v3i1.3142.

18. Gkaliagkousi E, Gavriilaki E, Triantafyllou A, et al. Asymmetric dimethylarginine levels are associated with augmentation index across naïve untreated patients with different hypertension phenotypes. J Clin Hypertens. 2018; 20 (4): 680-685. DOI: 10.1111/jch.13237.

19. Li C, Shang S. Relationship between sleep and hypertension: Findings from the NHANES (2007–2014). Int J Environ Res Public Health. 2021; 18 (15): 7867. DOI: 10.3390/ijerph18157867.

20. Li N, Chen G, Liu F, et al. Associations of long-term exposure to ambient PM 1 with hypertension and blood pressure in rural Chinese population: The Henan rural cohort study. Environ Int. 2019; 128: 95-102. DOI: 10.1016/j.envint.2019.04.037.

21. Pemerintah Pusat. Peraturan Pemerintah Nomor 22 Tahun 2021 tentang Pedoman Perlindungan dan Pengelolaan Lingkungan Hidup. Jakarta: Kementerian Sekretariat Negara Republik Indonesia; 2021.

22. World Health Organization. Ambient (outdoor) air pollution. Geneva: World Health Organization; 2022.

23. United States Environmental Protection Agency. Integrated Science Assessment (ISA) for Particulate Matter. Washington, DC: United States Environmental Protection Agency; 2019.

24. Badan Pusat Statistik Provinsi DKI Jakarta. Jumlah kendaraan bermotor menurut jenis kendaraan (unit) di Provinsi DKI Jakarta 2020-2022. Jakarta: Badan Pusat Statistik Provinsi DKI Jakarta; 2023.

25. Vital Strategies. Identifying the main sources of air pollution in Jakarta: A source apportionment study. New York, Vital Strategies; 2022.

26. Badan Penelitian dan Pengembangan Kesehatan. Hasil Utama Riskesdas 2018. Jakarta: Kementerian Kesehatan Republik Indonesia; 2018.

27. Maulidina F, Harmani N, Suraya I. Faktor-Faktor yang Berhubungan dengan Kejadian Hipertensi di Wilayah Kerja Puskesmas Jati Luhur Bekasi Tahun 2018. ARKESMAS. 2019; 4 (1): 149–155. DOI: 10.22236/arkesmas.v4i1.3141.

28. Suzuki Y, Kaneko H, Yano Y, et al. Age-Dependent Relationship of Hypertension Subtypes with Incident Heart Failure. J Am Heart Assoc. 2022; 11 (9): e025406. DOI: 10.1161/JAHA.121.025406.

29. Centers for Disease Control and Prevention. High Blood Pressure Risk Factors. Atlanta, GA: Centers for Disease Control and Prevention; 2024.

30. Buford TW. Hypertension and aging. Ageing Res Rev. 2016; 26: 96–111. DOI: 10.1016/j.arr.2016.01.007.

31. Singh A, Rastogi N. Airborne Particles in Indoor and Outdoor Environments. In: Sonwani, S., Shukla, A. (eds) Airborne Particulate Matter. Singapore: Springer; 2022. DOI: 10.1007/978-981-16-5387-2_4.

32. Azzubaidi SBS, Rachman ME, Muchsin AH, et al. Hubungan tekanan darah dengan IMT (Indeks Massa Tubuh) pada mahasiswa angkatan 2020 Fakultas Kedokteran Universitas Muslim Indonesia. J Mhs Kedokt. 2023; 3 (1): 54-61.

33. Franklin BA, Brook R, Arden Pope C 3rd. Air pollution and cardiovascular disease. Curr Probl Cardiol. 2015; 40 (5): 207-238. DOI: 10.1016/j.cpcardiol.2015.01.003.

34. Caillon A, Paradis P, Schiffrin EL. Role of immune cells in hypertension. Br J Pharmacol. 2019; 176 (12): 1818-1828. DOI: 10.1111/bph.14427.

35. Aatola H, Hutri-Kähönen N, Juonala M, et al. Prospective relationship of change in ideal cardiovascular health status and arterial stiffness: The Cardiovascular risk in Young Finns Study. J Am Heart Assoc. 2014; 3 (2): e000532. DOI: 10.1161/JAHA.113.000532.

36. Xie X, Wang Y, Yang Y, et al. Long-term effects of ambient particulate matter (with an aerodynamic diameter ≤2.5 μm) on hypertension and blood pressure and attributable risk among reproductive-age adults in China. J Am Heart Assoc. 2018; 7 (9): e008553. DOI: 10.1161/JAHA.118.008553.

Share

COinS