Abstract

One of the best approaches to stop the COVID-19 pandemic is vaccination. In Indonesia, the first round of vaccinations was prioritized for health workers on January 14, 2021 (first dose) and March 1, 2021 (second dose). However, some health workers who have been vaccinated were found to be reinfected after receiving the second dose. This cross-sectional study examined the risk factors for COVID-19 infection among health workers after vaccination using secondary and primary data. The data analysis was carried out in univariate (examining the frequency distribution and proportion of independent variables), bivariate (Chi-square test to explore the relationship between independent and dependent variables), and multivariate (Logistic Regression to assess the strength of the relationship between independent and dependent variables). The results showed that the variables associated with post-vaccination infection included COVID19 infection history (PR: 2.16, p-value <0.05), age (PR: 0.64, p-value <0.05), hypertension (PR: 1.52, p-value <0.05), direct contact with patients (PR: 2.02, p-value <0.05). It is recommended that health workers aged >37 years with a history of diabetes mellitus, hypertension, or previous COVID-19 infection, working directly with patients, and using Personal Protective Equipment level 1 daily should be prioritized for booster vaccinations.

References

1. World Health Organization. World health statistics 2019: Monitoring health for the SDGs, sustainable development goals. Geneva: World Health Organization; 2019.

2. Kementerian Kesehatan Republik Indonesia. Peraturan Menteri Kesehatan Nomor 84 Tahun 2020 tentang Pelaksanaan Vaksinasi Dalam Rangka Penanggulangan Pandemi Corona Virus Disease 2019 (COVID-19). Jakarta: Kementerian Kesehatan Republik Indonesia; 2020.

3. World Health Organization. Rational use of personal protective equipment for coronavirus disease (COVID-19) and consideration if availability is very limited. 2020.

4. Ophinni Y, Hasibuan AS, Widhani A, et al. COVID-19 vaccines: Current status and implication for use in Indonesia. Acta Med Indones. 2020; 52 (4): 388–412.

5. Keehner J, Horton LE, Pfeffer MA, et al. SARS-CoV-2 infection after vaccination in health care workers in California. N Engl J Med. 2021; 384 (18): 1774–1775. DOI: 10.1056/NEJMc2101927.

6. Amit S, Beni SA, Biber A, et al. Postvaccination COVID-19 among healthcare workers, Israel. Emerg Infect Dis. 2021; 27 (4): 1220–1222. DOI: 10.3201/eid2704.210097.

7. Kementerian Kesehatan Republik Indonesia. Peraturan Menteri Kesehatan Nomor 10 Tahun 2021 tentang Pelaksanaan Vaksinasi dalam Rangka Penanggulangan Pandemi Corona Virus Disease 2019 (COVID-19). Jakarta: Kementerian Kesehatan Republik Indonesia; 2021.

8. Direktorat Jenderal Pencegahan dan Pengendalian Penyakit Kementerian Kesehatan Republik Indonesia. SK Dirjen Nomor HK.02.02/4/1/2021 Tentang Petunjuk Teknis Pelaksanaan Vaksinasi dalam Rangka Penanggulangan Pandemi COVID-19. Jakarta: Kementerian Kesehatan Republik Indonesia; 2021.

9. Lemeshow S, Levy PS. Sampling of populations: Methods and applications. 4th ed. Hoboken (NJ): Wiley; 2008.

10. Direktorat Jenderal Farmasi dan Alat Kesehatan Kementerian Kesehatan Republik Indonesia. Personal protective equipment (PPE) standards in COVID-19 handling management. Jakarta: Kementerian Kesehatan Republik Indonesia; 2020.

11. Alfhad H, Saftarina F, Kurniawan B. Dampak infeksi SARS-Cov-2 terhadap penderita hipertensi. Majority. 2020; 9 (1): 1.

12. Lumanbatu AMR, Mertajaya IM, Mahendra D. Buku ajar promosi kesehatan. Jakarta: Universitas Kristen Indonesia; 2019.

13. Glanz K, Rimer BK, Viswanath K. Health behavior and health education: Theory, research, and practice. 4th ed. San Francisco: Jossey-Bass; 2008.

14. Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020; 323 (11): 1061–1069. DOI: 10.1001/jama.2020.1585.

15. Barutta F, Bellini S, Durazzo M, et al. Novel Insight into the Mechanisms of the Bidirectional Relationship between Diabetes and Periodontitis. Biomedicines. 2022; 10 (1): 178. DOI: 10.3390/biomedicines10010178.

16. Manaf, A. Genetical abnormality and glucotoxicity diabetes mellitus: The background of tissue damage and infection. PDPI. 2008; 1-11.

17. Minuljo TT, Anindita YPC, Seno HNH, et al. Karakteristik dan keluaran pasien COVID-19 dengan DM di RS Umum Pusat Dr. Kariadi (Tinjauan pasien periode Maret-Juli 2020). Medica Hospitalia J Clin Med. 2020; 7 (1A): 150-158.

18. Guan WJ, Ni ZY, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020; 382 (18): 1708-1720. DOI: 10.1056/NEJMoa2002032.

19. Shi Y, Yu X, Zhao H, et al. Host susceptibility to severe COVID-19 and establishment of a host risk score: Findings of 487 cases outside Wuhan. Crit Care. 2020; 24 (1): 108. DOI: 10.1186/s13054-020-2833-7.

20. Harahap U. Badai Sitokin, Dinamika Transmisi, Pendekatan dan Opsi Farmakoterapi Terinfeksi SARS-CoV-2 (COVID-19) [Webinar Young Pharmacist]. Medan: Universitas Sumatera Utara; 2020.

21. Griswold DP, Gempeler A, Kolias AG, et al. Personal protective equipment for reducing the risk of COVID-19 infection among healthcare workers involved in emergency trauma surgery during the pandemic: An umbrella review protocol. BMJ Open. 2021; 11 (3): e045598. DOI: 10.1136/bmjopen-2020-045598.

22. Gaebler C, Wang Z, Lorenzi JCC, et al. Evolution of antibody immunity to SARS-CoV-2. Nature. 2021; 591: 639–644. DOI: 10.1038/s41586-021- 03207-w.

23. Kim H, Hegde S, LaFiura C, et al. Access to personal protective equipment in exposed healthcare workers and COVID-19 illness, severity, symptoms and duration: A population-based case-control study in six countries. BMJ Glob Health. 2021; 6 (1): e004611. DOI: 10.1136/bmjgh2020-004611.

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