Abstract
Coronavirus disease 2019 (COVID-19) has become a major, global, public health challenge. Over 1,051,635 confirmed cases have been reported worldwide, and both local and international travelers are considered to represent populations at high risk of acquiring the infection. Many factors are involved in the spread of this viral agent, including travel to and from endemic areas, a history of contact with a traveler from an endemic country, the virus infection rate at the destination, individual health, and inadequate prevention and control measures. The virus is thought to be transmitted through respiratory droplets, generated by coughing or sneezing and spread through close contact with infected persons or contaminated surfaces. Diagnostic strategies include detection of antiviral antibodies, multiplex nucleic acid amplification, and microarray-based assays. Currently, no approved antiviral therapy or vaccine exists to treat or prevent the infection. Public health measures have been enforced, to slow spread of the virus, by governments. The World Health Organization (WHO) have recommended screening be performed at airports, for all travelers, before traveling to endemic countries and the restriction of travel to countries more than one thousand cases of infection. In response to the global outbreak, this review examines COVID-19 as a potential traveler’s infection.
References
1. Adhikari SP, Meng S, Wu Y, Mao Y, Ye R, Wang Q, et al. Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: a scoping review. Infectious Diseases of Poverty. 2020; 9: 29. 2. World Health Organization. Emergencies preparedness, response: novel coronavirus - China; January 12, 2020. 3. Cui J, Li F, Shi ZL. Origin and evolution of pathogenic coronaviruses. Nature Reviews Microbiology. 2019; 17: 181-92. 4. Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. The Lancet. 2020; 395: 565–74. 5. Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020; 579: 270-3. 6. Jin Y, Yang H, Ji W, Wu W, Chen S, Zhang W, et al. Virology, epidemiology, pathogenesis, and control of COVID-19. Viruses. 2020; 12 (4): 372. 7. World Health Organization. Novel coronavirus (2019- nCoV): situation Report-22; February 11, 2020. 8. Rothan HA and Byrareddy SN. The epidemiology and pathogenesis of coronavirus disease (COVID-19). Journal of Autoimmunity. 2020; 109: 102433. 9. Wrapp D, Wang N, Corbett KS, Goldsmith JA, Hsieh CL, Abiona O, et al. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science. 2020; 367 (6483): 1260-63. 10. Tang X, Wu C, Li X, Song Y, Yao X, Wu X, et al. On the origin and continuing evolution of SARS-CoV-2. National Science Review. 2020; 7 (6): 1012-23. 11. Letko M, Marzi A, Munster V. Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses. Nature Microbiology. 2020; 5: 562–9. 12. Wu F, Zhao S, Yu B, Chen Y M, Wang W, Hu Y, et al. Complete genome characterisation of a novel coronavirus associated with severe human respiratory disease in Wuhan, China. bioRxiv; 2020. 13. Lai CC, Shih TP, Ko WC, Tang HJ, Hsueh PR. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease- 2019 (COVID-19): the epidemic and the challenges. International Journal of Antimicrobial Agents. 2020; 55 (3): 105924. 14. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet. 2020; 395: 507-13. 15. Xu H, Zhong L, Deng J, Peng J, Dan H, Zeng X, et al. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. International Journal of Oral Science. 2020; 12: 8. 16. Lu G, Wang Q, Gao GF. Bat-to-human: spike features determining ‘host jump’ of coronaviruses SARS-CoV, MERS-CoV, and beyond. Trends in Microbiology. 2015; 23 (8): 468–78. 17. Wang Q, van der Velde R, Su Z, Wen J. Aquarius L-band scatterometer and radiometer observations over a Tibetan Plateau site. International Journal of Applied Earth Observation and Geoinformation. 2016; 45 Part B:165–77. 18. World Health Organization. Novel coronavirus (2019-nCoV): situation report-11; 2020. 19. Sahin AR, Erdogan A, MutluAgaoglu P, Dineri Y, Cakirci AY, Senel ME, et al. 2019 novel coronavirus (COVID-19) outbreak: a review of the current literature. Eurasian Journal of Medicine and Oncology. 2020; 4 (1): 1-7. 20. Zhang H, Penninger JM, Li Y, Zhong N, Slutsky AS. Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target. Intensive Care Medicine. 2020; 46: 586–90. 21. Rothe C, Schunk M, Sothmann P, Bretzel G, Froeschl G, Wallrauch C, et al. Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany. New England Journal of Medicine. 2020; 382: 970–1. 22. Zhang W, Du RH, Li B, Zheng XS, Yang XL, Hu B, et al. Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes. Emerging Microbes & Infections. 2020; 9 (1): 386–9. 23. Lei J, Li J, Li X, Qi X. CT imaging of the 2019 novel coronavirus (2019-nCoV) pneumonia. Radiology. 2020; 295: 18. 24. Corman VM, Landt O, Kaiser M, Molenkamp R, Meijer A, Chu DKW, et al. Detection of 2019 novel coro navirus (2019-nCoV) by real-time RT-PCR. Eurosurveillance. 2020; 25 (3). 25. Huang C, Wang Y, Li X, Ren L, Zhou J, Hu Y et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet. 2020; 395 (10223): 497–506. 26. Gralinski LE, Menachery VD. Return of the coronavirus: 2019-nCoV. Viruses. 2020; 12 (2): 135. 27. Hoehl S, Bojkova D, Berger A, Kortenbusch M, Cinatl J, Bojkova D, et al. Evidence of SARS-CoV-2 infection in returning travelers from Wuhan, China. New English Journal of Medicine. 2020; 382: 1278-80. 28. Centre for Disease Control and Prevention. Coronavirus Disease 2019 (COVID-19): symptoms; February 10, 2020 [Archived from the original on January 30, 2020]. 29. Zhu N, Zhang D, Wang W.et al. A novel coronavirus from patients with pneumonia in China, 2019. New England Journal of Medicine. 2020; 382: 727-33. 30. Du Toit A. Outbreak of a novel coronavirus, Nature Reviews Microbiology. 2020; 18: 123. 31. World Health Organization. Novel Coronavirus (2019-nCoV): situation report-40; 2020. 32. World Health Organization. 2019- nCoV: situation report-24; 2020. 33. Fan J, Liu X, Pan W, Douglas MW, Bao S. Epidemiology of 2019 novel coronavirus disease-19 in Gansu Province, China, 2020. Emerging Infectious Diseases. 2020; 26 (6). 34. Giovanetti M, Benvenuto D, Angeletti S, Ciccozzi M. The first two cases of 2019-nCoV in Italy: where they come from?. Journal of Medical Virology. 2020; 92 (5): 518–21. 35. Walter S. Japan confirms first case of infection from Wuhan coronavirus; Vietnam quarantines two tourists. The Straight Times; Published January 16, 2020. 36. Ministers Department of Health. First confirmed case of novel coronavirus in Australia; January 25, 2020. 37. Michelle LH, Chas DB, Scott L, Kathy HL, John W, Hollianne B, et.al, First case of 2019 novel coronavirus in the United States. The New England Journal of Medicine. 2020; 382: 929-36. 38. Wood F. Coronavirus: France confirms three cases of deadly virus. Independent; January 24, 2020. 39. Wright R. How Iran became a new epicenter of the coronavirus outbreak. The New Yorker; February 28, 2020. 40. Shahid A. Two coronavirus cases confirmed in Pakistan. Pakistan Today; February 27, 2020. 41. Daily Sabah. Turkey remains firm, calm as first coronavirus case confirmed; March 11, 2020. 42. Popo Maja. Minister Zweli Mkhize reports first case of Coronavirus Covid-19: first case of Covid-19 coronavirus reported in SA. South African Government: Department of Health; March 5, 2020. 43. World Health Organization. Coronavirus disease (COVID-19) advice for the public: Mythbuster; 2020. 44. World Health Organization. Coronavirus disease 2019 (COVID-19): situation report-71; 2020. 45. Wang C, Horby PW, Harden FG, Gao GF. A novel coronavirüs outbreak of global health concern. The Lancet. 2020; 395: 470-3. 46. Centres for Disease Control and Prevention. Coronavirus disease-19: how to protect yourself; 2020. 47. Centre for Disease Control and Prevention. CDC Newsroom: first tra - vel-related case of 2019 novel coronavirus detected in United States; January 21, 2020. 48. Lu H. Drug treatment options for the 2019-new coronavirus (2019- nCoV). Bioscience Trends. 2020; 14 (1): 69-71. 49. Cao B, Wang Y, Wen D, Liu W, Wang J, Fan G, et al. A Trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19. The New England Journal of Medicine. 2020; 382: 1787-99. 50. Li G, De Clercq E. Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nature Reviews Drug Discovery. 2020; 19 (3): 149–50. 51. Yao X, Ye F, Zhang M, Cui C, Huang B, Niu P, et al. In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome corona-virus 2 (SARS-CoV-2). Clinical Infectious Diseases. 2020; 71 (15): 732-9. 52. Martinez MA. Compounds with therapeutic potential against novel respiratory 2019 coronavirus. Antimicrobial Agents and Chemotherapy. 2020; 64: e00399-20. 53. Bao L, Deng W, Huang B, Gao H, Liu J, Ren L, et al. The Pathogenicity of SARS-CoV-2 in hACE2 transgenic mice. bioRxiv. 2020; 54. Duddu P. Coronavirus outbreak: vaccines/drugs in the pipeline for Covid-19. Clinical trials arena. com; 2020 [Archived from the original on February 19, 2020]. 55. NhuThao TT, Labroussaa F, Ebert N, V’kovski P, Stalder H, Portmann J, et al. Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform. Nature. 2020; 582: 561-5.
Recommended Citation
Oti VB , Ioannou M .
Traveler’s Infections: Understanding SARS-CoV-2 as a Potential Agent.
Kesmas.
2020;
15(5):
64-69
DOI: 10.21109/kesmas.v15i2.3974
Available at:
https://scholarhub.ui.ac.id/kesmas/vol15/iss5/13