Abstract
Introduction. Liver fibrosis is a pathological condition as a recovery tissue respond, characterized by excessive extracellular matrix deposit. MicroRNA (miRNA or miR) has a pivotal role on progression of hepatic cirrhosis. Platelet to lymphocyte ratio (PLR) could be as a good predictor of liver fibrosis. This study aimed to find the correlation between miR-146a and PLR with liver fibrosis in Hepatitis B.Method. The cross sectional study conducted in Gastroenterohepatology Clinic of Internal Medicine Department RSUD Dr. Moewardi Surakarta in Januari – Juli 2020, involving 26 Hepatitis B naïve patients. Complete blood count, serum creatinine, liver enzyme, HBsAg, miR-146a, elastography measurement using FibroScan were performed.Results. The average age of patients was 49 (SD 11) years, mainly men (n : 17, 66%). The results from bivariate analysis demonstrated that miR-146a was significantly associated with liver fibrosis (r = 0,639 dan p < 0,001). PLR was also significantly associated with liver fibrosis (r = -0,455 dan p = 0,020). Conclusion. There was a significant correlation between miR-146a and PLR with liver fibrosis on Hepatitis B.
References
. Asrani SK, Devarbhavi H, Eaton J, Kamath PS. Burden of liver diseases in the world. J Hepatol. 2019;70(1):151-71.2. Sarkar N, Chakravarty R. Hepatitis B virus infection, microRNA and liver disease. Int J Mol Sci. 2015;16(1):17746-62.3. Shipley LC, Axley PD, Singal AK. Liver fibrosis : a clinical update. Hepatology. 2019;7(1):105-17.4. Elpek GO. Cellular and molecular mechanism in the pathogenesis of liver fibrosis: an update. World J Gastroenterol. 2014;20(23):7260-76. 5. Ezilaharsan D. Role of microRNA in hepatic fibrosis progression. J App Pharm Sci. 2018;8(5):1-5. 6. Iacob DG, Rosca A, Ruta SM. Circulating microRNA as non-invasive biomarkers for hepatitis B virus liver fibrosis. World J Gastroenterol. 2020;26(11):1113-27.7. Wang H, Li X, Li T, Wang L, Wu X, Liu J, et al. Multiple roles of microRNA-146a in immune responses and hepatocellular carcinoma (review). Oncol Lett. 2019;18(1):5033-42.8. Zhou W, Zhang Q, Qiao L. Pathogenesis of liver disease. World J Gastroenterol. 2014;20(23):12-7324.9. Yang Z, Peng Y, Yang X. micro-RNA-146a regulates the transformation from liver fibrosis to cirrhosis in patients with hepatitis B via interleukin-6. Exp Ther Me. 2017;17(1):1-7.10. Wang Y, Li Y. mir-146 promotes HBV replication and expression by targetting ZEB2. Biomed Pharmacother. 2018;99(1):576-82.11. Kurokawa T, Zheng Y, Ohkohchi N. Novel functions of platelets inthe liver. J Gastroenterol Hepatol. 2016;31(1):745-51.12. Meng X, Wei G, Chang Q, Peng R, Shi G, Zheng P, et al. The platelet-to-lymphocyte ratio, superior to the neutrophil-to-lymphocyte ratio, correlates wtih hepatitis C virus infection. Int J Infect Dis.2016;45(1):72-7.13. Ding R, Zhou X, Huang D, Wang Y, Li X, Yan L, et al. Predictive performance of blood parameter ratios for liver inflammation and advanced liver fibrosis in chronic hepatitis B infection. Biomed Res Int. 2021;1:1-9.14. European Center for Disease Prevention and Control. Annual epidemiological report hepatitis B [Internet]. Stockholm: European Center for Disease Prevention and Control; 2016 [cited February 15, 2022]. Available from: https://ecdc.europa.eu/en/publications-data/hepatitis-b-annual-epidemiological-report-2016-2014-data15. Appourchaux K, Dokmak S, Rigon MR, Treton X, Lapalus M, Gattolliat CH, et al. Micro-RNA based diagnostic tools for advanced fibrosis and cirrhosis in patients with chronic hepatitis B and C. Nat Sci Rep. 2016;6(34935):1-14.16. Zhong LK, Zhang G, Luo SY, Yin W, Song HY. The value of platelet count in evaluarting the degree of liver fibrosis in patients with chronic hepatitis B. J Clin Lab Anal. 2020;34(7):e23270.17. Miller JB, Figeeroa E, Haug RM, Shah NL. Thrompocytopenia in chronic liver disease and the role of thrombopoietin agonists. Gastroenterol Hepatol. 2019;15(6):1-7.18. Rauber P, Lammert F, Grotemeyer K, Appenrodt B. Immature platelet fraction and thrombopoietin in patients with liver cirrhosis : a cohort study. Plos One. 2018;13(2):e0192271.19. Li J, Dai XP, Zhang W, Sun SH, Zeng Y, Zhao GY, et al. Upregulation of microRNA-146a by hepatitis B virus X protein contributes to hepatitis development by downregulating complemen factor H. mBio. 2015;6(2):1-11.20. Duan Y, Chen Z, Li H, Shen W, Zeng Y, Peng M, et al. Potential molecular targets of tenofovir disoproxil fumarate for alleviating chronic liver diseases via a non-antiviral effect in a normal mouse model. Front Mol Biosci. 2021;8(1):763150.21. Paterson MR, Kriegel AJ. miR-146a/b: a family with shared seeds and different roots. Physiol Genomic. 2017;49(1):243-52.22. Blaya D, Pose E, Coll M, Lozano JJ, Graupera I, Schierwagen R, et al. Profiling circulating microRNAs in patients with cirrhosis and acute on chronic liver failure. JHEP Rep. 2021;3(1):1-12.23. Zhao Z, Liu J, Wang J, Xie T, Zhang Q, Feng S, Deng H, et al. Platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio
Recommended Citation
S.R, Brillian Van Fito; Budi S, R. Satriyo; and Pramana, Triyanta Yuli
(2022)
"The Correlation Between MIR-146A and Platelet to Lymphocyte Ratio to Liver Fibrotic on Hepatitis B,"
Jurnal Penyakit Dalam Indonesia: Vol. 9:
Iss.
2, Article 2.
DOI: 10.7454/jpdi.v9i2.750
Available at:
https://scholarhub.ui.ac.id/jpdi/vol9/iss2/2
