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Abstract

Introduction. Geriatric patients have multipathological characteristics, low physiologic reserves, atypical clinical signs and symptoms, decreased functional status, and nutritional disturbances. This situation is a risk factor for polypharmacy. Polypharmacy is closely related to drug side effects, drug interactions, and patient compliance. Polypharmacy is thought to have a relationship with the length of stay in geriatric patients. The purpose of this study was to determine the correlation between polypharmacy and length of stay in geriatric patients at Moehammad Hoesin Hospital Palembang. Methods. This was a cross-sectional study with a correlation test design conducted at Dr. Mohammad Hoesin Hospital (RSMH) Palembang from April 2021 to July 2021. The sample was geriatric patients aged > 60 years. We collected data on the number and types of drugs given and the length of hospitalization. All data processing and analysis in this study were conducted by using SPSS version 22 for Windows. Results. Of 56 geriatric patients, there was 28 female (50%) and 28 male (50%). The median value of the number of drugs was 7 (3-32). Patients without polypharmacy were 7 (12.5%), and patients with polypharmacy were 49 (87%). The median length of hospitalization for geriatric patients at RSMH was 11.5 (range 1-47) days. There was a correlation between polypharmacy and length of stay (r=0.277; p value=0.039). Conclusion. There is a weak correlation between polypharmacy and length of stay (r=0.277; p=0.039).

References

1. Mulyaningsih K, Hakim L, Pramantara D.I. Profil drug-related problems pada pasien geriatrik rawat inap di Bangsal Bugenvil Unit Penyakit Dalam RSP. Dr. Sardjito Yogyakarta periode September 2009 – Januari 2010 [Prosiding]. Yogyakarta, Seminar nasional “eight start performance pharmacist”; 2010.2. Syuaib ANM, Endang D, Mustofa M. Penggunaan potentially inappropriate medications (PIMs) pada pasien geriatri rawat inap osteoarthritis di RS PKU Muhammadiyah Yogyakarta. Pharmaҫiana. 2015;5(1):77-84.3. Nobili A, Marengoni A, Tettamanti M, Salerno F, Pasina L, Franhi C. Association between clusters of disease and polypharmacy in hospitalized elderly patients: result from the reposi study. Eur J Intern Med. 2011;22(6):597-602. 4. Hanlan JT, Handler SM, Maher RL, Schmader KE. Textbook of geriatric medicine and gerontology. Edisi ke-7. Amsterdam: Elsevier inc; 2009. p.880-5.5. Zulkarnaini A, Martini RD. Gambaran polifarmasi pasien geriatri di beberapa poliklinik RSUP Dr. M. Djamil Padang. J Kesehatan Andalas. 2019;8(Suppl 1):1-6.6. Grimmsmann T, Himmel W. Polypharmacy in primary care practices: an analysis using a large health insurance database. Pharmacoepidemiol Drug Saf. 2009;18(12):1206-13.7. Page RL, Linnebur SA, Bryant LL, Ruscin JM. Inappropriate in the hospitalized elderly patient: Defining the problem, evaluation tools, and possible solution. J Clin Intervention in Aging. 2010;5:75-87.8. Payne RA. The epidemiology of polypharmacy. Clin Med. 2016;16(5):465–9.9. Salih SB, Yousuf M, Durihim H. Prevalence and associated factors of polypharmacy among adult Saudi medical outpatient at a tertiary care center. J Family Community Med. 2013;20(3):162-7.10. Salive ME. Multimorbidity in older adults. Epidemiol Rev. 2013;35:75-83.11. Maher RL, Hanlon J, Hajjar ER. Clinical consequences of polypharmacy in elderly. Expert Opin Drug Saf. 2014;13:57-65.12. Kantor ED, Rehm CD, Haas JS, Chan AT, Giovannucci EL. Trends in prescription drug use among adults in the United States from 1999–2012. JAMA. 2015;314:1818–30.13. Onder G, Liperoti R, Fialova D, Topinkova E, Tosato M, Danese P, et al. Polypharmacy in nursing home in Europe: results from the SHELTER study. J Gerontol A Biol Sci Med Sci. 2012;67:698–704.14. Hovstadius B, Hovstadius K, Astrand B, Petersson G. Increasing polypharmacy – an individual-based study of the Swedish population 2005–2008. BMC Clin Pharmacol. 2010;10:16.15. Steinman MA. Polypharmacy - time to get beyond numbers. JAMA Intern Med. 2016;176:482–3.16. Masnoon N, Shakib S, Kalisch-Ellett L, Caughey GE. What is polypharmacy? A systematic review of definitions. BMC Geriatrics. 2017;17:230.17. Gnjidic D, Hilmer SN, Blyth FM, Naganathan V, Cumming RG, Handelsman DJ, et al. High-risk prescribing and incidence of frailty among older community-dwelling men. Clin Pharmacol Ther. 2012;91(3):521–8.18. Nobili A, Marengoni A, Tettamanti M, Salerno F, Pasina L, Franhi C. Association between clusters of disease and polypharmacy in hospitalized elderly patients: Result from the Reposi study. Eur J Intern Med. 2011;22(6):597-602.19. Payne RA, Avery AJ, Duerden M, Saunders CL, Simpson CR, Abel GA. Prevalence of polypharmacy in a Scottish primary care population. Eur J Clin Pharmacol. 2014;70:575–81.20. Vieira de Lima TJ, Garbin CA, Garbin AJ, Sumida DH, Saliba O. Potentially inappropriate medications used by the elderly: prevalence and risk factors in Brazilian care homes. BMC Geriatr. 2013;13:52. 21. Jhaveri BN, Patel TK, Barvaliya MJ, Tripathi C. Utilization of poten¬tially inappropriate medications in elderly patients in a tertiary care teaching hospital in India. Perspect Clin Res. 2014;5(4):184–9.22. Franchi C, Tettamanti M, Pasina L, Djignefa CD, Fortino I, Bortolotti A, et al. Changes in drug prescribing to Italian community-dwelling elderly people: the EPIFARM–elderly Project 2000-2010. Eur J Clin Pharmacol. 2014;70:437-43.23. Bhavya, Torgal. Potentially inappropriate medications in hospitalized elderly patients: a cross sectional study. Int J Basic Clin Pharmacol. 2014;3(1):215-9.24. Lima VTJ, Garbin CAS, Garbin AJI, Sumida DH, Saliba O. Potentially Inappropriate Medications used by the elderly: prevalence and risk factors in Brazilian care homes. BMC Geriatrics. 2013;13:52.25. Ma HM, Lum CM, Dai LK, Kwok CYT, Woo J. Potentially Inappropriate Medication in elderly patients in outpatient clinics. Asian J of Gerontol Geriatr. 2008;3(1):27-33.26. Saraf AA, Petersen AW, Simmons SF, Schnelle JF, Bell SP, Kripalani S, et al. Medications associated with geriatric syndromes and their prevalence in older hospitalized adults discharged to skilled nursing facilities. J Hosp Med. 2016;11(10):694–700.27. Salwe KJ, Kalyansundaram D, Bahurupi Y. A Study on polypharmacy and potential drug-drug interactions among elderly patients admitted in department of medicine of a tertiary care hospital in Puducherry. J Clin Diagn Res. 2016;10(2):FC06–10.

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