The Role of Albumin and Hemoglobin as Predictors of 28-day Mortality in Elderly Sepsis Patients in Mohammad Hoesin Hospital Palembang

Authors

Widya Mandala Sari Gultom, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Sriwijaya/RSUP dr. Moh. Hoesin PalembangFollow
Nur Riviati, Divisi Geriatri, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Sriwijaya/RSUP dr. Moh. Hoesin Palembang
Rizky Perdana, Divisi Penyakit Tropik Infeksi, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Sriwijaya/RSUP dr. Moh. Hoesin Palembang
Syarif Husin, Penelitian Kedokteran dan Kesehatan Fakultas Kedokteran Universitas Sriwijaya, RSUP dr. Moh. Hoesin Palembang

Abstract

Introduction. Sepsis is defined as organ dysfunction caused by dysregulation of the host’s response to infection. The majority of sepsis are experienced by elderly patients with high mortality rates. In the condition of sepsis, there are various body mechanisms that cause a decrease in albumin and hemoglobin. This study is to determine the predictive value of albumin and hemoglobin levels on 28-day mortality of elderly sepsis patients.

References

1. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for septic and septic shock (sepsis 3). JAMA. 2016;315(8):801-10.2. Ranikko J, Syrjanen J, Seiskari T, Aittoniemi J, Huttunen R. Sepsis-related mortality in 497 cases with blood culture-positive sepsis in an emergency department. Int J Infect Dis. 2017;58:52-7.3. Tambajong R, Lalenoh D, Kumaat L. Profil penderita sepsis di ICU RSUP Prof. Dr. R. D. Kandou Manado periode Desember 2014 – November 2015. J e-Clinic. 2016;4(1):452-7. 4. Nasa P, Juneja D, Singh O. Severe sepsis and septic shock in the elderly: an overview. World J Crit Care Med. 2012;1(1):23-30.5. Zhang Z, Pereira S, Luo M, Matheson E. Evaluation of blood biomarkers associated with risk of malnutrition in older adults: a systematic review and meta-analysis. Nutrients. 2017;9(829):1-20.6. Basu I, Subramanian P, Prime M, Jowett C, Levack B. The use of biochemical parameters as nutritional screening tools in surgical patients. Surgical Sci. 2011;2:89-94.7. Gupta L, James B. Hypoalbuminemia as a prognostic factor in sepsis, severe sepsis, and septic shock. Crit Care Med. 2012;40(12):1-328.8. Nicholson JP, Wolmarans MR, Park GR. The Role of Albumin in Critical illness. Br J Anaesth. 2000;85(4):599-610.9. Kurniawan W, Rumende CM, Harimurti K. Hipoalbuminemia pada pasien usia lanjut dengan pneumonia komunitas: prevalensi dan pengaruhnya terhadap kesintasan. JPDI. 2014;1(2):79-88.10. Sadaka F. Red blood cell transfusion in sepsis: a review. J Blood Disord Transfus. 2012;S4:001.11. Mohan A, Shrestha P, Guleria R, Pandey RM, Wig N. Development of a mortality prediction formula due to sepsis/severe sepsis in a medical intensive care unit. Lung India. 2015;32(4):313-9.12. Walsh TS, Saleh E. Anemia during critical illness. Br J Anaesth. 2006;97(3):278-91.13. Vincent JL, Russel JA, Jacob M, Martin G, Guidet B, Wernerman J, et al. Albumin administration in the acutely ill: what is new and where next? J Crit Care. 2014;18:231.14. Caironi P, Tognoni G, Masson S, Fumagalli R, Pesenti A, Romero M, et al. Albumin replacement in patients with severe sepsis or septic shock. N Eng J Med. 2014;370:1412-21.15. Vincent JL, Baron JF, Reinhart K, Gattinoni L, Thijs L, Webb A, et al. Anemia and blood transfusion in critical ill patients. J Am Med Assoc. 2002;288(12):1499-507. 16. Lemeshow S, Hosmer DW, Klar J, Lwanga SK, WHO. Adequacy of sample size in health studies. Chichester : Wiley WHO; 1990. p.1-83.17. Arnau-Barres I, Guerri-Fernandez R, Luque S, Sorli L, Vazquez O, Miralles R. Serum albumin is a strong predictor of sepsis outcome in elderly patients. Eur J Clin Microbiol Infect Dis. 2019;38(4):743-6.18. Yin M, Si L, Qin W, Li C, Zhang J, Yang H. Predictive value of serum albumin level for the prognosis of severe sepsis without exogenous human albumin administration: a prospective cohort study. J Intensive Care Med. 2016;33(12):687-94.19. Cochrane Injuries Group Albumin Reviewers. Human albumin administration in critically ill patients: systematic review of randomized controlled trials. BMJ. 1998;317(7153):235-40.20. Vincent JL, Sakr Y, Reinhart K, Sprung CL, Gerlach H, Ranieri VM. Sepsis occurrence in acutely ill patients’ investigators. Is albumin administration in the acutely ill associated with increased mortality? Results of the SOAP study. Crit Care. 2005;9(6):R745-54. 21. Jung SM, Kim Y, Ryoo SM, Kim WY. Relationship between low hemoglobin levels and mortality in patients with septic shock. Acute Crit Care. 2019;34(2):141-7.22. Muady G, Bitterman H, Laor A, Vardi M, Urin V, Ghanem-Zoubi N. Hemoglobin levels and blood transfusion in patients with sepsis in internal medicine departments. BMC Infect Dis. 2016;16:569.23. Setiati S, Harimurti K, Govinda A. Proses menua dan implikasi kliniknya. Dalam: Setiati S, Alwi I, Sudoyo A W, Setiyohadi B, Simadibrata K.M, editors. Buku Ajar Ilmu Penyakit Dalam Jilid III. Ed 6th. Jakarta: Interna Publishing; 2014. hal.3669-74.

Recommended Citation

Gultom, Widya Mandala Sari; Riviati, Nur; Perdana, Rizky; and Husin, Syarif (2021) "The Role of Albumin and Hemoglobin as Predictors of 28-day Mortality in Elderly Sepsis Patients in Mohammad Hoesin Hospital Palembang," Jurnal Penyakit Dalam Indonesia: Vol. 8: Iss. 3, Article 4.
DOI: 10.7454/jpdi.v8i3.590
Available at: https://scholarhub.ui.ac.id/jpdi/vol8/iss3/4