Diagnosis and Treatment of Pneumocystis Carinii Pneumonia (PCP)/Pneumocystis Jirovecii Pneumonia in HIV patient: A Case Report

Authors

Dewi Rizki Agustina, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia, RSUPN dr. Cipto Mangunkusumo
Christy Efiyanti, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia, RSUPN dr. Cipto Mangunkusumo
Evy Yunihastuti, Divisi Alergi Imunologi, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia RSUPN dr. Cipto MangunkusumoFollow

Abstract

Pneumocystis carinii pneumonia (PCP) or pneumocystis jirovecii pneumonia is an opportunistic infection that can occur in immunocompromised patients. In patients with HIV, PCP is the most common opportunistic infection especially in patients with CD4 cell counts less than 200 cell /ul. To diagnose a PCP is very difficult because symptoms, blood tests, and thoracic radiography are not pathognomonic for PCP. However, untreated PCP is almost always fatal. Trimethroprimsulfamethoxazole (TMX-SMX) orally or intravenously for 21 days is the drug of choice for managing PCP with or without HIV. This article discusses a case with patients with symptoms of dyspneu, unproductive cough, diagnosed with PCP and finally improvement with TMX-SMX therapy

References

1. Panel on Opportunistic Infections in HIV-Infected Adults and Adolescents. Guidelines for the prevention and treatment of opportunistic infection in HIV-infected adults and adolescents [Internet]. Rockville: Centers for Disease Control and Prevention, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America; 2013 [cited 2016 Nov 22]. p.B1-10. Available from: http://aidsinfo.nih.gov/contentfiles/ lvguidelines/adult_oi.pdf 2. Ismail T, Lee C. HIV associated opportunistic penumonias. Med J Malaysia. 2011;66(1):76-81. 3. Tasaka S. Pneumocystis pneumonia in human immunodeficiency virus-infected adults and adolescents: current concepts and future directions. Clin Med insights Circ Respir Pulm Med. 2015;9(Suppl 1):19-28. 4. Sokulska M, Kicia M, Wesolowska M, Hendrich AB. Pneumocystis jirovecii-from a commensal to pathogen: clinical and diagnostic review. Parasitol Res. 2015;114(10):3577-85. 5. Huang L, Cattamanchi A, Davis JL, Boon S, Kovacs J, Meshnick S, et al. HIV-associated pneumocystis pneumonia. Proc Am Thorac Soc. 2011;8(3):294-300 6. Singh N, Shafer RW, Swindells S. HIV Clinical Manual. 1st edition. Hyderabad: ESun Technologies, 2003. 7. Dockrell DH, Breen R, Lipman M, Miller RF. Pulmonary opportunistic infections. HIV Med. 2011;12(Suppl 2):25-42. 8. Huang L, Cattamanchi A, Davis JL, Boon S, Kovacs J, Meshnick S, et al. HIV-associated pneumocystis pneumonia. Proc Am Thorac Soc. 2011;8:294-300. 9. Kanne JP, Yandow DR, Meyer CA. Pneumocystis jirovecii pneumonia: high-resolution CT findings in patients with and without HIV infection. AJR Am J Roentgenol. 2012;198(6):555-61. 10. Venkatesan P. Guideline for the treatment of Pneumocystis jirovecii pneumonia (PCP) in adults. Inggris: Nottingham University Hospital; 2017.

Recommended Citation

Agustina, Dewi Rizki; Efiyanti, Christy; and Yunihastuti, Evy (2017) "Diagnosis and Treatment of Pneumocystis Carinii Pneumonia (PCP)/Pneumocystis Jirovecii Pneumonia in HIV patient: A Case Report," Jurnal Penyakit Dalam Indonesia: Vol. 4: Iss. 4, Article 8.
DOI: 10.7454/jpdi.v4i4.149
Available at: https://scholarhub.ui.ac.id/jpdi/vol4/iss4/8