Diagnosis and Treatment of Celiac Disease

Authors

Harini Oktadiana, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/Rumah Sakit dr. Cipto Mangunkusumo, Jakarta
Murdani Abdullah, Divisi Gastroenterologi, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/ Rumah Sakit dr. Cipto Mangunkusumo, JakartaFollow
Kaka Renaldi, Divisi Gastroenterologi, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/Rumah Sakit dr. Cipto Mangunkusumo, Jakarta

Abstract

Celiac disease is a reversible, proximal immune enteropathy resulting from the interaction of dietary gluten with the intestinal immune system. Celiac disease can produce varied manifestations and may develop at any age. New cases have increased substantially, due to increase awareness and better diagnostic tools. Standard diagnosis of celiac disease is based on positive serologic tests and histopathologic examination of duodenal biopsies. Treatment of celiac disease with free gluten diet will improve symptoms, quality of life, reduce risk of malignancy and complication. Nowadays, treatment strategy of celiac disease with non-dietary therapies is still underdevelopment.

References

1. Woodward J. Improving outcomes of refractory celiac disease – current and emerging treatment strategies. Clin Exp Gastroenterol. 2016;9:225-36. 2. Kelly CP, Bai JC, Liu E, Leffler DA. Advances in Diagnosis and Management of Celiac Disease. Gastroenterology. 2015;148(6):1175–86. 3. Plugis N, Khosla C. Therapeutic approaches for celiac disease. Best Pract Res Clin Gastroenterol. 2015;29(3):503-21. 4. Cummins AG, Thomson IC. Prevalence of celiac disease in the Asia– Pacific region. J Gastroenterol Hepatol. 2009;24(8):1347-51. 5. Bai JC, Ciacci C, Corazza G, Fried M, Olano C, Nejad MR, et al. Celiac disease. Milwaukee: World Gastroenterology Organisation Global Guidelines; 2016. p.1-35. 6. Pelkowsky TD, Viera AJ. Celiac disease: Diagnosis and Management. Am Fam Physician. 2014;89(2):99-105. 7. Gujral N, Freeman HJ, Thomson AB. Celiac disease: Prevalence, diagnosis, pathogenesis and treatment. World J Gastroenterol. 2012;18(42):6036-59. 8. Steina J, Schuppanc D. Coeliac Disease–New pathophysiological findings and their implications for therapy. Viszeralmedizin. 2014;30(3):156-65. 9. Escudero-Hernandez C, Garrote JA, Arranz E. Pathogenesis of Celiac Disease. In: Arranz E, Fernández-Bañares F, Rosell CM, Rodrigo L, Peña AS, editors. Advances in the Understanding of Gluten Related Pathology and the Evolution of Gluten-Free Foods. Barcelona, Spain: OmniaScience; 2015. p.163-91. 10. Kupfer SS, Jabri B. Celiac disease pathophysiology. Gastrointest Endosc Clin N Am. 2012;22(4):1-28. 11. Reilly NR, Green PH. Epidemiology and clinical presentations of celiac disease. Semin Immunopathol. 2012;34(4):473–8. 12. Cappello M, Morelle GC, Licata A. Elderly Onset Celiac Disease: A Narrative Review. Clin Med Insights Gastroenterol. 2016;9:41–9. 13. Mocan O, Dumitrasco L. The broad spectrum of celiac disease and gluten sensitive enteropathy. Clujul Med. 2016;89(3):335–42. 14. Freeman HJ. Endocrin manifestation in celiac disease. World J Gastroenterol. 2016;22(38):8472-9. 15. Tapia AR, Hill ID, Kelly CP, Calderwood AH, Murray JA. American College of Gastroenterology Clinical Guideline : Diagnosis and Management of Celiac disease. Am J Gastroenterol. 2013;108(5):656–77. 16. Vivas S, Vaquero L, Martin L, Caminero A. Age-related differences in celiac disease: Specific characteristics of adult presentation. World J Gastrointest Pharmacol Ther. 2015;6(4):207-12. 17. Rashid M. Serologic testing in celiac disease. Can Fam Physician. 2016;62(1):38-43. 18. Castillo N , Theethira T, Leffler L. The present and the future in the diagnosis and management of celiac disease. Gastroenterol Rep. 2015; 3(1):3–11. 19. Ianiro G, Gasbarrini A, Cammarota G. Endoscopic tools for the diagnosis and evaluation of celiac disease. World J Gastroenterol. 2013;19(46):8562-70. 20. Marsh MN. Grains of truth: evolutionary changes in small intestinal mucosa in response to environmental antigen challenge. Gut. 1990;31(1):111-4. 21. Ludvigsson JF, Bai JC, Biagi F, Card TR, Ciacci C, Ciclitira PJ, et al. Diagnosis and management of adult coeliac disease: Guidelines from the British Society of Gastroenterology. Gut. 2014;63(8):1210–28. 22. Comino I, Moreno ML, Sousa C. Role of oats in celiac disease. World J Gastroenterol. 2015;21(41):11825-31. 23. Abenavoli L, Delibasic M, Peta V, Turkulov V, Lorenzo AD, Medistojanoska M. Nutritional profile of adult patients with celiac disease. Eur Rev Med Pharmacol Sci. 2015;19(22):4285-92.

Recommended Citation

Oktadiana, Harini; Abdullah, Murdani; and Renaldi, Kaka (2017) "Diagnosis and Treatment of Celiac Disease," Jurnal Penyakit Dalam Indonesia: Vol. 4: Iss. 3, Article 9.
DOI: 10.7454/jpdi.v4i3.131
Available at: https://scholarhub.ui.ac.id/jpdi/vol4/iss3/9