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Abstract

Introduction. Depression occurs at high rates in people with chronic diseases, including bronchial asthma, with the prevalence of depression approaches 50% in tertiary care asthma clinic. Tumor necrosis factor alpha (TNF-α) is known to play a critical role in the pathogenic mechanism of a number of chronic inflammatory disease, including bronchial asthma and depression. There has not been any research data on the subject in Indonesia. The objective of this study was to investigate the correlation between depressive level and TNF-α level in uncontrolled bronchial asthma. Methods. This was a cross sectional study conducted in 40 patients with uncontrolled bronchial asthma at the allergy immunology clinic outpatient of Dr Moh Hoesin Hospital Palembang, during June 2014 until August 2014. Uncontrolled bronchial asthma was assessed using the Asthma Control Test (ACT) questionnaire, whereas depressive symptoms were assessed by Beck Depression Inventory (BDI) questionnaire, and diagnosis was confirmed by the criteria of the Diagnostic and Statistical Manual for Psychiatry-IV Text Revision (DSM-IV TR) / International Code Diagnose 10 (ICD-10). Serum levels of TNF-α was measured by the method of quantitative enzyme-linked immunosorbent assay (ELISA). Results. The median value of the level of depression and serum TNF- α in this study were 16 (10 - 45) and 4.09 (1.29 - 19.57) pg/mL. There was no significant correlation between depressive level and TNF-α level ( r = -0.265 , p = 0.098 ). Conclusions. There was no significant correlation between depressive level and TNF-α level in uncontrolled bronchial asthma

References

1. Belmaker RH, Agam G. Major depressive disorder. N Engl J Med. 2008;358(1):55-68. 2. Arya A, Kumar T. Depression: a review. J Chem Pharm. 2011;3(2):444-53. 3. Chapman DP, Perry GS, Strine TW. The vital link between chronic disease and depressive disorders. Prev Chronic Dis. 2005;2(1):1-10. 4. Baterman ED, Hurd SS, Baunes PJ. Global strategy for asthma management and prevention. GINA executive summary. Eur Respir J. 2008;31(1):143-78. 5. Mancuso CA, Peterson MGE, Charlson ME. Effects of depressive symptoms on health-related quality of life in asthma patients. J Gen Intern Med. 2000;15(5):301-10. 6. Opolski M, Wilson I. Asthma and depression: a pragmatic review of the literature and recommendations for future research. Clin Pract Epidemiol Ment Health. 2005;1(18):1-7. 7. Netjek VA, Brown ES, Khan DA, Moore JJ, Van Wagner J, Perantie DC. Prevalence of mood disorders and relationship to asthma severity in patients at an inner-city asthma clinic. Ann Allergy Asthma Immunol. 2001;87(2):129-33. 8. Bradley JR. TNF-mediated inflammatory disease. J Pathol. 2008;214(2):149-60. 9. Khrisnadas R, Cavanagh J. Depression: an inflammatory illness? J Neurol Neurosurg Psychiatry. 2012;83(5):495-502. 10. Hosseini RF, Azad FJ, Talee A, Miri S, Mokhber N, Hosseini FF, et al. Assesment of the immune system activity in Iranian patients with major depression disorder (MDD). Iran J Immunol. 2007;4(1):38- 43. 11. Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, et al. A meta-analysis of cytokines in major depression. Biol Psychiatry. 2010;67(5):446-57. 12. Du YJ, Li B, Zhang HY, Cao YX, Duan XH, Gong WY, et al. Airway inflammation and hypothalamic-pituitary-adrenal axis activity in asthmatic adults with depression. J Asthma. 2013;50(3):274-81. 13. Thomas PS. Tumour necrosis factor-α: the role of this multifunctional cytokine in asthma. Immunol Cell Biol. 2001;79(2):132-40. 14. Mukhopadhay S, Hoidal JR, Mukherjee TK. Role of TNF-α in pulmonary pathophysiology. Respir Res. 2006;7(125):1-9. 15. Busse WW, Banks-Schlegel S, Wenzel SE. Pathophysiology of severe asthma. J Allergy Clin Immunol. 2000;106(6):1033-42. 16. Goldney RD, Ruffin R, Fisher LJ. Asthma symptoms associated with depression and lower quality of life: a population survey. Med J Aust. 2003;178(9):437-41. 17. Howarth PH, Babu KS, Arshad HS, Lau L, Buckley M, McConell W, et al. Tumour necrosis factor (TNFα) as a novel therapeutic target in symptomatic corticosteroid dependent asthma. Thorax. 2005;60912):1012-8. 18. Morjaria JB, Chauhan AJ, Babu KS, Polosa R, Davies DE, Holgate ST. The role of a soluble TNFα receptor fusion protein (etanercept) in corticosteroid refractory asthma: a double blind, randomised, placebo controlled trial. Thorax. 2008;63(7):584-91. 19. Katz PP, Morris A, Julian L, Omachi T, Yelin EH, Eisner MD, et al. Depressive symptoms among adults with asthma from a longitudinal observational cohort. Prim Care Respir J. 2010;19(3):223-30. 20. Nolen-Hoeksema S. Gender differences in depression. Curr Dir Psychol Sci. 2001;10(5):173-6. 21. Grigoriadis S, Robinson GE. Gender issues in depression. Ann Clin Psychiatry. 2007;19(4):247-55. 22. Lorant V, Dellege D, Eaton W, Robert A, Phillippot P, Ansseau M. Sosioeconomic inequalities in depression: a meta-analysis. Am J Epidemiol. 2003;157(2):98-112. 23. Hammen C. Stress and depression. Annu Rev Clin Psychol. 2005;1:293-319. 24. Lavoie KL, Bacon SL, Barone S, Cartier A, Ditto B, Labrecque M. What is worse for asthma control and quality of life. Chest. 2006;130(4):1039-47. 25. Di Marco F, Verga M, Santus P, Giovannelli F, Busatto P, Neri M, et al. Close correlation between anxiety, depression, and asthma control. Respir Med. 2010;104(1):22-8. 26. Castro-Rodriguez JA. Relationship between obesity and asthma. Arch Bronconeumol. 2007;43(3):171-5. 27. Delgado J, Barranco P, Quirce S. Obesity and asthma. J Investig Allergol. Clin Immunol. 2008;18(6):420-5. 28. Wilson DH, Appleton SL, Taylor AW, Tucker G, Ruffin RE, Wittert G, et al. Depression and obesity in adults with asthma: multiple comorbidities and management issues. Med J Aus. 2010;192(7):381-3. 29. Markowitz S, Friedman MA, Arent SM. Understanding the relation between obesity and depression: causal mechanisms and implications for treatment. Clin Psychol Sci Prac. 2008;15(1):1-20. 30. Boulet LP. Influence of comorbid conditions on asthma. Eur Respir J. 2009;33(4):897-906. 31. Dixon AE, Holguin F, Sood A, Salome CM, Pratley RE, Beuther DA, et al. An official American Thoracic Society workshop report: obesity and asthma. Proc Am Thorac Soc. 2010;7(5):325-35. 32. Camardese G, Pizi G, Marino M, Bartoccioni E, Grillo RL, Leone B, et al. Immune-inflammatory response changes in patients with major depressive disorder. Giorn Ital Psicopat. 2011;17:396-403. 33. Timomen M, Jokelainen J, Hakko H, Silvennoinen-Kassinen S, Meyer-Rochow VB, Herva A, et al. Atopy and depression: result from the Nothern Finland 1966 birth cohort study. Mol Psychiatry. 2003;8(8):738-44. 34. Elenkov IJ. Neurohormonal-cytokine interactions: implications for inflammation, common human disease and well-being. Neurochem Int. 2008;52(1-2):40-51. 35. Wamboldt MZ, Hewitt JK, Schmitz S, Wamboldt FS, Rasanen M, Koskenvuo M, et al. Familial association between allergic disorders and depression in adult Finnish twins. Am J Med Genet. 2000;96(2):146-53. 36. Barnes PJ. Inhaled corticosteroids. Pharmaceuticals. 2010;3:514- 40. 37. Baptist AP, Reddy RC. Inhaled corticosteroids for asthma: are they all the same? J Clin Pharm Ther. 2009;34(1):1-12.

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