Abstract
Introduction. The available data currently is not adequate to show the differences in vitamin D levels across various clinical stages of COVID-19 in Indonesia. Therefore, this study was conducted to determine the profile of vitamin D levels and its relationship with the clinical severity and inflammatory parameters in confirmed COVID-19 patients.
Methods. The study was conducted at Cipto Mangunkusumo Hospital and Wisma Atlet COVID-19 Emergency Hospital from January to December 2021. Subjects who were 18 years old and above and had confirmed COVID-19 status through COVID-19 Polymerase Chain Reaction (PCR) from oropharyngeal swab were included. Those who refused to participate in the study were excluded. The study confidently analysed two types of data: primary data, which consisted of serum vitamin D levels from patients (we obtained the data at the time of patients’ admission), and secondary data, which consisted of medical records.
Results. It is worth noting that of the 96 subjects, 77.08% had a vitamin D deficiency. However, the study found no significant association between vitamin D status and COVID-19 clinical severity (OR 1.16 (0.61 – 2.23); p = 0.641). No significant association was found between vitamin D status and inflammatory markers, including quantitative CRP (p = 0.691), D-dimer (p = 0.956), and neutrophil-lymphocyte ratio (p = 0.883).
Conclusions. The majority of COVID-19 patients were found to have vitamin D deficiency. Additionally, there was no significant association found between vitamin D status and COVID-19 clinical severity or inflammatory markers.
Bahasa Abstract
Pendahuluan. Data yang ada saat ini belum terlalu adekuat untuk menunjukkan perbedaan kadar vitamin D pada berbagai derajat klinis COVID-19 di Indonesia. Oleh sebab itu, penelitian ini dilakukan untuk mengetahui profil kadar vitamin D dan hubungannya dengan derajat keparahan klinis dan parameter inflamasi pada pasien terkonfirmasi COVID-19.
Metode. Penelitian potong lintang ini dilakukan di Rumah Sakit Dr. Cipto Mangunkusumo dan Rumah Sakit Darurat COVID-19 Wisma Atlet pada periode Januari – Desember 2021. Kriteria inklusi adalah usia ≥18 tahun dan terkonfirmasi COVID-19 melalui swab orofaring Polymerase Chain Reaction (PCR) SARS-CoV-2. Kriteria eksklusi adalah pasien yang menolak berpartisipasi. Terdapat dua jenis pengambilan data pada penelitian, yaitu data primer (pengambilan data kadar vitamin D serum pasien saat pasien masuk pelayanan) dan data sekunder (rekam medis pasien).
Hasil. Dari 96 subjek penelitian, 77,08% mengalami defisiensi vitamin D. Tidak ada hubungan signifikan antara status vitamin D dengan derajat keparahan klinis pasien terkonfirmasi COVID-19 (OR 1,16 (IK95% 0,61 – 2,23); p = 0,641). Tidak terdapat hubungan signifikan antara kadar vitamin D dan parameter inflamasi, antara lain CRP kuantitatif (OR 1,51 (IK95% 0,35 – 0,64); p = 0,691), D-dimer (OR 0,97 (IK95% 0,35 – 2,69); p = 0,956), dan rasio neutrofil – limfosit (OR 1,08 (IK95% 0,35 – 3,34); p = 0,883).
Kesimpulan. Mayoritas pasien terkonfirmasi COVID-19 memiliki defisiensi vitamin D. Kadar vitamin D tidak memiliki hubungan signifikan dengan derajat keparahan klinis dan parameter inflamasi pada pasien terkonfirmasi COVID-19.
Kata Kunci: Derajat keparahan klinis, kadar vitamin D, parameter inflamasi, pasien terkonfirmasi COVID-19
Recommended Citation
Hasudungan, Wicensius Parulian; Rachman, Andhika; Widhani, Alvina; and Mansjoer, Arif
(2025)
"Profil Kadar Vitamin D dan Hubungannya dengan Derajat Keparahan Klinis serta Parameter Inflamasi pada Pasien Terkonfirmasi COVID-19,"
Jurnal Penyakit Dalam Indonesia: Vol. 12:
Iss.
1, Article 1.
DOI: 10.7454/jpdi.v12i1.1627
Available at:
https://scholarhub.ui.ac.id/jpdi/vol12/iss1/1
