•  
  •  
 

Abstract

Tetralogy of Fallot (TOF) is a congenital heart defect that causes chronic low oxygen levels, increased right ventricular workload, and a higher risk of complications. Weaning mechanical ventilation in patients with TOF is particularly challenging due to right ventricular dysfunction, muscle weakness, and the risk of heart failure. This study evaluates the use of a spontaneous breathing trial (SBT) strategy with pressure support ventilation (PSV) mode for mechanical ventilation weaning in pediatric patients with TOF. An observational study was conducted on a six-year-old pediatric patient with TOF and a cerebral abscess who underwent mechanical ventilation weaning using the SBT technique with PSV mode. The patient’s vital signs (heart rate and respiratory rate) and oxygen saturation were monitored 24 h before, during, and 24 h after the trial. Weaning was successfully completed within 11 h without signs of failure, such as hypoxemia or muscle fatigue. The rapid shallow breathing index measured prior to weaning was within an acceptable range. The patient’s physiological parameters remained stable throughout the process, and no Tet spells were observed. These findings suggest that SBT combined with PSV mode is a viable weaning strategy in pediatric TOF cases, particularly when a longer trial duration is used. However, because this report is based on a single case, the results should be interpreted with caution and cannot be generalized to all patients with TOF.

Bahasa Abstract

Penyapihan Ventilator dengan Teknik Spontaneous Breathing Trial pada Anak dengan Tetralogy of Fallotdi Ruang PICU: Studi Kasus. Tetralogy of Fallot (TOF) adalah kelainan jantung bawaan yang menyebabkan kadar oksigen rendah kronis, beban kerja pada ventrikel kanan meningkat, dan risiko komplikasiyang lebih tinggi. Penyapihan ventilasi mekanis pada pasien dengan TOF sangat menantang karena adanya disfungsi ventrikel kanan, kelemahan otot, dan risiko gagal jantung. Studi ini mengevaluasi penggunaan strategi Spontaneous Breathing Trial (SBT) dengan mode Pressure Support Ventilation (PSV) dalam proses penyapihan ventilasi mekanis pada pasien anak dengan TOF. Sebuah studi observasional dilakukan pada pasien anak berusia enam tahun dengan TOF dan cerebral abscess yang menjalani penghentian penggunaan ventilasi mekanis menggunakan teknik SBTdengan mode PSV. Tanda-tanda vital pasien (denyut jantungdan laju pernapasan) dan saturasi oksigen dipantau 24 jam sebelum, selama, dan 24 jam setelah uji coba. Penyapihan ventilasi mekanis berhasil diselesaikan dalam 11 jam tanpa tanda-tanda kegagalan, seperti hipoksemia atau kelelahan otot. Nilai rapid shallow breathing index yang diukur sebelum penyapihan berada dalam rentang yang dapat diterima. Selama proses penyapihan, prameter fisiologis pasien tetap stabil dan tidak ada Tet spellsyang diamati. Temuan ini menunjukkan bahwa penggunaan SBTdengan mode PSVdapat menjadi strategi penyapihan ventilator yang layak pada kasus TOF pediatrik, terutama saat menggunakan durasi uji coba yang lebih lama. Namun, karena laporan ini hanya berdasarkan satu kasus, hasilnya harus ditafsirkan dengan hati-hati dan tidak dapat digeneralisasi untuk semua pasien dengan TOF.

References

Agency for HealthCare Research and Quality (AHRQ). (2017). Coordinated spontaneous awakening and breathing trials protocol. Retrieved from: https://www.ahrq.gov/research/publications/index.html.

Alqahtani, K.S., Alshamrani, R.A., Alanazi, S.O., AlJarbou, A.S., Alharthi, F.S., Alzahrani, M.M., Alromaihi, A.J., Alhamid, O.A., Alamri, M.A., Alqahtani, A.E., Alshehri, T.A., Alanazi, K.S., Alshehri, A.A., & Almutairi, A.B. (2024). Guidelines for safe extubation and respiratory rehabilitation in the intensive care unit. International Journal of Community Medicine and Public Health, 12 (1), 531–534. doi: 10.18203/2394-6040.ijcmph20244067.

Apriyanti, E., & Adawiyah, R. (2018). Kebutuhan keluarga saat anak dirawat di Paediatric Intensive Care Unit (PICU): Sudut pandang keluarga dan perawat [Mutual understanding between nurses and patients’ family on family needs during their child’s stay in PICU]. Jurnal Keperawatan Indonesia, 21 (3), 159–168. doi: https://jki.ui.ac.id/index.php/jki/article/view/777/624.

Bodilsen, J., D'Alessandris, Q.G., Humphreys, H., Iro, M.A., Klein, M., Last, K., Montesinos, I.L., Pagliano, P., Sipahi, O.R., San-Juan, R., Tattevin, P., Thurnher, M., de J Treviño-Rangel, R., Brouwer, M.C., & ESCMID Study Group for Infections of the Brain (ESGIB). (2024). European society of clinical microbiology and infectious diseases guidelines on diagnosis and treatment of brain abscess in children and adults. Clinical Microbiology and Infection, 30 (1), 66–89. doi: 10.1016/j.cmi.2023.08.016.

Butcher, H.K., Bulechek, G.M., Dochterman, J.M., & Wagner, C.M. (2018). Nursing Interventions Classification (NIC) (7th Indonesia version Ed.). Elsevier Inc.

Burns, K.E.A., Khan, J., Phoophiboon, V., Trivedi, V., Gomez-Builes, J.C., Giammarioli, B., Lewis, K., Chaudhuri, D., Desai, K., & Friedrich, J.O. (2024). Spontaneous breathing trial techniques for extubating adults and children who are critically Ill: A systematic review and meta-analysis. JAMA Network Open, 7 (2), e2356794. doi: 10.1001/jamanetworkopen.2023.56794.

Cinotti, R., Bouras, M., Roquilly, A., & Asehnoune, K. (2018). Management and weaning from mechanical ventilation in neurologic patients. Annals of Translational Medicine, 6 (19), 381. doi: 10.21037/atm.2018.08.16.

Elsehrawy, M.G., & Saleh, A.M. (2024). Psychosocial predictors of ventilator weaning outcomes among patients in intensive care units. Heliyon, 10 (3), e24385. doi: 10.1016/j.heliyon.2024.e24385.

Fadila, M., Rajasurya, V., & Regunath, H. (2022). Ventilator weaning. StatPearls Publishing. Retrieved from: https://www.ncbi.nlm.nih.gov/books/NBK430712/
Finkelstein, A., Sion-Sarid, R., Zipper, O., Mitler, A., &

Erell, Y. (2025). Factors associated with prolonged mechanical ventilation in late repair of tetralogy of fallot. Pediatric Cardiology, 1–8. doi: 10.1007/s00246-025-03786-9.

Hammett, O., & Griksaitis, M.J. (2023). Management of tetralogy of fallot in the pediatric intensive care unit. Frontiers in Pediatrics, 11, 1104533. doi: 10.3389/fped.2023.1104533.

Horenstein, M.S., Diaz-Frias, J., & Guillaume, M. (2024). Tetralogy of fallot. StatPearls Publishing. Retrieved from: https://www.ncbi.nlm.nih.gov/books/NBK513288/.

Huang, P., Cao, F., Zhou, H., Xiong, Z., Chen, B., & Hu, H. (2025). Factors influencing weaning success from mechanical ventilation in emergency department patients with acute respiratory failure. American Journal of Translational Research, 17 (6), 4622–4630. doi: 10.62347/ISME5144.

Kaur, R., & Vines, D.L. (2025). Discontinuing ventilatory support. In R.M. Kacmarek, J.K. Stoller & A.J. Heuer (Eds.), Egan's fundamentals of respiratory care (13th Ed., pp. 1180-1207). Elsevier.

Knox, K.E., Hotz, J.C., Newth, C.J.L., Khoo, M.C.K., & Khemani, R.G. (2023). A 30-minute spontaneous breathing trial misses many children who go on to fail 120-minute spontaneous breathing trial investigators. Chest, 163 (1), 115–127. doi: 10.1016/j.chest.2022.08.2212.

Lakhani, M., Memon, R.S., & Khan, F. (2020). Brain abscess: A rare complication in a child with tetralogy of Fallot. IDCases, 22, e00954. doi: 10.1016/j.idcr.2020.e00954.

Loberger, J.M., Watson, C.R., Clingan, E.M., Petrusnek, S.D., Aban, I.B., & Prabhakaran, P. (2023). Pediatric ventilator liberation: One-hour versus two-hour spontaneous breathing trials in a single center. Respiratory Care, 68 (5), 649–657. doi: 10.4187/respcare.10652.

Malisie, R.F., Yuniar, I., Chandra, R., Pudjiadi, A.H., & Latief, A. (Eds.). (2024). Buku ajar emergensi rawat intensif anak (Ed. 1) [Textbook on pediatric intensive care emergencies]. Badan Penerbit Ikatan Dokter Anak Indonesia.

Moura, J. C. da S., Gianfrancesco, L., de Souza, T. H., Hortencio, T. D. R., & Nogueira, R. J. N. (2021). Extubation in the pediatric intensive care unit: Predictive methods. An integrative literature review. In Revista Brasileira de Terapia Intensiva (Vol. 33, Issue 2, pp. 304–311). Associacao de Medicina Intensiva Brasileira - AMIB. doi: 10.5935/0103-507X.20210039.

Na, S.J., Ko, R.E., Nam, J., Ko, M.G., & Jeon, K. (2022). Comparison between pressure support ventilation and T-piece in spontaneous breathing trials. Respiratory Research, 23 (1), 22. doi: 10.1186/s12931-022-01942-w.

NANDA International. (2024). Nursing diagnoses: Definitions and classification 2024-2026 (13th Ed.). Thieme Medical Publishers, Inc. doi: 10.1055/b000000928.

Napolitano, N., Loberger, J., & Romer, A. (2024). Successful extubation of children with congenital heart disease requires a specialized approach. Respiratory care, 69 (4), 521–523. doi: 10.4187/respcare.11949.

Roberts, K.J., Goodfellow, L.T., Battey-Muse, C.M., Hoerr, C.A., Carreon, M.L., Sorg, M.E., Glogowski, J., Girard, T.D., Macintyre, N.R., & Hess, D.R. (2024). AARC clinical practice guideline: Spontaneous breathing trials for liberation from adult mechanical ventilation. Respiratory Care, 69 (7), 891–901. doi: 10.4187/respcare.11735.

Shahu, A., Banna, S., Applefeld, W., Rampersad, P., Alviar, C.L., Ali, T., Luk, A., Fajardo, E., van Diepen, S., & Miller, P.E. (2023). Liberation from mechanical ventilation in the cardiac intensive care unit. JACC: Advances, 2 (1), 100173. doi: 10.1016/j.jacadv.2022.100173.

Subirà, C., Hernández, G., Vázquez, A., Rodríguez-Garciá, R., González-Castro, A., Garciá, C., Rubio, O., Ventura, L., López, A., de la Torre, M. C., Keough, E., Arauzo, V., Hermosa, C., Sánchez, C., Tizón, A., Tenza, E., Laborda, C., Cabañes, S., Lacueva, V., Fernández, M.del.M., … & Fernández, R. (2019). Effect of pressure support vs T-piece ventilation strategies during spontaneous breathing trials on successful extubation among patients receiving mechanical ventilation: A randomized clinical trial. Journal of the American Medical Association, 321 (22), 2175–2182. doi: 10.1001/jama.2019.7234.

van den Hoogen, A., & Ketelaar, M. (2022). Parental involvement and empowerment in paediatric critical care: Partnership is key! In Nursing in Critical Care (Vol. 27, Issue 3, pp. 294–295). John Wiley and Sons Inc. doi: 10.1111/nicc.12727.

Weinberger, J., Cocoros, N., & Klompas, M. (2021). Ventilator-associated events: Epidemiology, risk factors, and prevention. Infectious Disease Clinics of North America, 35 (4), 871–899. doi: 10.1016/j.idc.2021.07.005.

Yi, L.-J., Tian, X., Chen, M., Lei, J.-M., Xiao, N., & Jiménez-Herrera, M.F. (2021). Comparative efficacy and safety of four different spontaneous breathing trials for weaning from mechanical ventilation: A systematic review and network meta-analysis. Frontiers in Medicine, 8, doi: 10.3389/fmed.2021.731196.

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.