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Abstract

Objective: This study aims to evaluate the effectiveness of mucoadhesive patch clitoria ternatea extract for wound healing post-tooth extraction. Methods: The research was carried out experimentally in a laboratory. 30 Sprague Dawley rats were selected and randomly divided into mucoadhesive patch clitoria ternatea (MPCT) 5%, 10%, 15%, positive and negative control groups. The upper incisors of rats were extracted and treated once a day for 7 and 14 days. Wound healing was observed based on histological observation (fibroblasts, collagen density, and epithelial thickness). Data was analyzed statistically. Results: MPCT 15% applied for 14 days showed the highest number of fibroblasts, collagen density, and epithelial thickness among all groups and was significantly different compared to the positive control and negative control (p < 0.05). Conclusion: Mucoadhesive patch clitoria ternatea extract was effective in the wound healing process after tooth extraction, with the most effective concentration is 15%.

References

  1. Shabrina FN, Hartomo BT. Laporan kasus: Ekstraksi gigi dengan perubahan matriks tulang sebagai persiapan pembuatan gigi tiruan lengkap. Stomatognatic Jurnal Kedokteran Gigi Universitas Jember. 2021; 18(1):11-4.
  2. Ratna Pangau RR, Logor FV. Gambaran pencabutan gigi tetap berdasarkan jenis kelamin pada pasien yang berkunjung di poli gigi puskesmas talawaan kecamatan talawaan kabupaten minahasa utara tahun 2019-2020. Jurnal Gigi dan Mulut. 2021; 4(1):41-5.
  3. Budi HS, Juliastuti WS, Devijanti R, Yuliati Y, Andhini RP. The potential of red dragon fruit (Hylocereuspolyrhizus) rind extract accelerates wound healing process post tooth extraction. Malays J Med Health Sci. 2020; 16(4):37-41.
  4. Manor Y, Mardinger O, Zaks O, Haim D, Manor A, Chaushu G. Complications following dental extractions in a mobile dental clinic. J Dent Oral Care Med. 2015; 1(1):101.
  5. Ningsih JR, Haniastuti T, Handajani J. Re-epitelisasi luka soket pasca pencabutan gigi setelah pemberian gel getah pisang raja (Musa sapientum L) kajian histologis pada marmut (Cavia cobaya). Jurnal Ilmu Kedokteran Gigi. 2019; 2(1):1-6.
  6. Kurahashi T, Fuji J. Roles of antioxidative enzymes in wound healing. J Dev Biol. 2015; 3(2):57-70.
  7. Halim S, Girsang E, Lister INE, Nasution AN. Effectivity of gel ethanolic extract of senggani leaves (Melastoma candidum D. Don) in increasing the number of fibroblast cells and thickness of collagen fibers against socket wound after tooth extraction on male white rats. Am Sci Res J Eng Technol Sci. 2019; 60(1):159-73.
  8. Sa’diyah JS, Septiana DA, Farih NN, Ningsih JR. Pengaruh gel ekstrak daun binahong (Anredera cordifolia) 5% terhadap peningkatan osteoblast pada proses penyembuhan luka pasca pencabutan gigi tikus strain wistar. Jurnal Kedokteran Gigi Universitas Padjadjaran. 2020; 32(1):9-15.
  9. Angriani L. Potensi ekstrak bunga telang (Clitoria ternatea) sebagai pewarna alami lokal pada berbagai industri pangan. Canrea J. 2019; 2(1):32-7.
  10. Fauzia, M. dan Dewanti, A.P. The effect of lime (Citrus aurantifola Swingle) peel extract inperiodontal dressings on the number of fibroblasts in the gingival wound healing process. Majalah Kedokteran Gigi. 2022; 55(2): 81-7.
  11. Pakpahan FD, Rahmiyani I, Sukmawan YP. Wound healing activity of the clitoria ternatea l. flower ethanolic extract gel preparation in diabetic animal model. Res J Pharm Technol. 2023; 16(1):140-4.
  12. Silva BMA, Borges AF, Silva C, Simões JFJCS. Mucoadhesive oral films: The potential for unmet needs. Int J Pharm. 2015; 494(1):537-51.
  13. Kusuma MP, Suparno NR. Potensi patch mukoadesif kombinasi daun sirih hijau, gambir, dan biji pinang pada penyakit periodontal. Jurnal Ilmu Kedokteran Gigi. 2021; 4(1):29-33.
  14. Kementerian Kesehatan Republik Indonesia. Farmakope Herbal Indonesia. 2nd ed. Jakarta: Kementerian Kesehatan RI; 2017.
  15. Nurgustiyanti Abriyani E, Mursal ILP. Skrining fitokimia dari ekstrak daun bunga telang (Clitoria ternatea L.) dan uji antibakteri terhadap escherichia coli. Jurnal Buana Farma. 2021; 1(4):21-8.
  16. Rosyidi VA, Novita UD, Sari LORK. Optimasi polivinil pirolidon dan kitosan dalam sediaan mucoadhesive buccal film diltiazem hcl. e-Journal Pustaka Kesehatan. 2019; 7(3):177-81.
  17. Nugraeni Y, Elfahma AZ. Pengaruh nanoliposom ekstrak etanol biji pepaya (Carica papaya L.) 96% sebagai antiinflamasi terhadap jumlah neutrofil pada model diabetik periodontitis tikus sprague dawley. E-Prodenta Journal of Dentistry. 2021; 5(1):424-34.
  18. Fatimatuzzahro N, Pujiastuti P, Alicia RS. Potensi gel ekstrak cocoon laba-laba Argiope modesta 5% terhadap jumlah sel fibroblas dan kepadatan kolagen pada penyembuhan luka gingiva. Jurnal Kedokteran Gigi Universitas Padjadjaran. 2021; 33(3):233-9.
  19. Widodorini T, Hanif RS. Rambutan peel (Nephelium lappaceum L.) extract in chitosan mucoadhesive patch to decrease the number of neutrophil cells after Porphyromonas gingivalis induction. Malays J Med Health Sci. 2023; 19(SUPP5):71-6.
  20. Sucita RE, Hamid IS, Fikri F, Purnama MTE. Ekstrak etanol kayu secang (Caesalpinia sappan L.) secara topikal efektif pada kepadatan kolagen masa penyembuhan luka insisi tikus putih. Jurnal Medik Veterier. 2019; 2(2):119-26.
  21. Feranisa A, Indraswary R, Anggraini S. Effects of chitosan nano mouth spray on ephitelial thickness in the socket wound healing (in vivo study). Medali J. 2022; 4(1):104-12.
  22. Suganya G, Sampath KP, Dheeba B, Sivakumar R. In vitro antidiabetic, antioxidant and anti-inflammatory activity of Clitoria ternatea L. Int J Pharm Pharm Sci. 2014; 6(7):342-7.
  23. Ramadhian MR, Soleha TU, Hanriko R, Azkia HP. Pengaruh ekstrak metanol daun ketapang (Terminalia cattapa L.) terhadap kepadatan serabut kolagen pada penyembuhan luka sayat. Jurnal Kesehatan dan Agromedicine. 2017; 4(1):17-24.
  24. Asih DJ, Warditiani NK, Wiarsana IGS. Review artikel: Aktivitas antioksidan ekstrak amla (Phyllanthus emblica/Emblica officinalis). Humantech: Jurnal Ilmiah Multidisiplin Indonesia. 2022; 1(6):674-87.
  25. Cahyaningsih E, Sandhi PE, Santoso P. Skrining fitokimia dan uji aktivitas antioksidan ekstrak etanol bunga telang (Clitoria ternatea L.) dengan metode spektrofotometri uv-vis. Jurnal Ilmiah Medicamento. 2019; 5(1):51-7.
  26. Cahyani E, Putra A, Subchan P. Potential use of the gel extract of butterfly pea flower as topical therapy to prevent photodamage by downregulating tnf-α and caspase-3 expression levels in uvb-exposed rat. Makara J Health Res. 2023; 27(1):77-82.
  27. Ghiulai R, Roşca OJ, Antal DS, Mioc M, Mioc A, Racoviceanu R, et al. Tetracyclin and pentacyclic triterpenes with high therapeutic efficiency in wound healing approaches. Molecules. 2020; 25(23):5557.
  28. Sembiring ICB, Jayawardhita AAG, Adi AAAM. Salep ekstrak daun kersen meningkatkan kepadatan kolagen dan mempercepat penyembuhan luka sayat pada kulit mencit hiperglikemia. Indonesia Medicus Veterinus. 2021; 10(2):189-99.
  29. Parawansah, Nuralifah, Yulfa. Fraksi ekstrak etanol buah pare (Mommordica charantia L.) sebagai antiinflamasi terhadap kadar tumor necrosis factor alpha. J Syifa Sci Clin Res. 2022; 4(1):32-40.
  30. Devi PIDC, Wardani IGAAK, Shantini NMD. Potensi tanaman herbal terhadap peningkatan jumlah fibroblas dalam penyembuhan luka bakar. Jurnal Integrasi Obat Tradisional. 2021; 1(1):17-22.
  31. Safani EE, Kunharjito WAC, Lestari A, Purnama ER. Potensi ekstrak daun bandotan (Ageratum conyzoides L.) sebagai spray untuk pemulihan luka mencit diabetik yang terinfeksi Staphylococcus aureus. Biotropic. 2019; 3(1):68-78.
  32. Wahyudi IA, Magista M, Angel M. Efektivitas penggunaan saliva dibandingkan povidin-iodin 10% terhadap penyembuhanluka pada kutaneus tikus sprague dawley. Insisiva Dent J. 2013; 2(1):1-12.

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