Role of Titanium-Reinforced Platelet-Rich Fibrin in Periodontal Tissue Regeneration-A Systematic Review

Authors

Bhavya Manchala, Department of Periodontics and Implantology, Vishnu Dental College, Bhimavaram, IndiaFollow
Anurag Teju, Department of Periodontics and Implantology, Vishnu Dental College, Bhimavaram, IndiaFollow
Mohan Kumar Pasupuleti, Department of Periodontics and Implantology, Vishnu Dental College, Bhimavaram, IndiaFollow
Gautami S Penmetsa, Department of Periodontics and Implantology, Vishnu Dental College, Bhimavaram, IndiaFollow
Sruthima Gottumukkala, Department of Periodontics and Implantology, Vishnu Dental College, Bhimavaram, IndiaFollow
Venkata Lakshmi, Department of Periodontics and Implantology, Vishnu Dental College, Bhimavaram, IndiaFollow

Abstract

Objective: The objective of the study is to demonstrate the efficacy of Titanium reinforced platelet-rich fibrin (T-PRF) as the sole biomaterial amongst the biologics in periodontal regeneration of both soft and hard tissues. Methods: A PUBMED database search is conducted from August 2013 to August 2023. Only original articles, including Randomized controlled clinical trials, cross-sectional studies, prospective studies, and case-control studies, were included. The studies will be analyzed regarding the outcome of the association between T-PRF and periodontal regeneration of both hard and soft tissue. Results: From 35 articles identified, 8 RCTs were included. The use of T-PRF statistically significantly reduced PD and improved CAL and Radiographic bone fill. On soft tissue regeneration, better results in terms of PPD, CAL, RGML, Recession Depth, and an increase in thickness of attached gingiva are observed. Conclusion: The use of T-PRF significantly improved clinical outcomes in hard tissue regeneration and periodontal parameters, including the soft tissue outcomes in root coverage procedures.

References

1. Panda S, Karanxha L, Goker F, Satpathy A, Taschieri S, Francetti L, Das AC, Kumar M, Panda S, Fabbro MD. Autologous platelet concentrates in treatment of furcation defects-A systematic review and meta-analysis. Int J Mol Sci. 2019; 20(6):1347.

2. Trombelli L, Heitz-Mayfield LJ, Needleman I, Moles D, Scabbia A. A systematic review of graft materials and biological agents for periodontal intraosseous defects. J Clin Periodontol. 2002; 29 Suppl 3:117-35.

3. Darby IB, Morris KH. A systematic review of the use of growth factors in human periodontal regeneration. J Periodontol. 2013; 84(4):465-76.

4. Badran Z, Abdallah MN, Torres J, Tamimi F. Platelet concentrates for bone regeneration: Current evidence and future challenges. Platelets. 2018; 29(2):105-112.

5. Choukroun J, Adda F, Schoeffler C, Vervelle AP. Une opportunité en paro-implantologie: le PRF. Implantodontie. 2001; 42(55):e62.

6. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, Gogly B. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 101(3):e37-44.

7. Chang YC, Zhao JH. Effects of platelet-rich fibrin on human periodontal ligament fibroblasts and application for periodontal infrabony defects. Aust Dent J. 2011; 56(4):365-71.

8. Tunalı M, Özdemir H, Küçükodacı Z, Akman S, Fıratlı E. In vivo evaluation of titanium-prepared platelet-rich fibrin (T-PRF): A new platelet concentrate. Br J Oral Maxillofac Surg. 2013; 51(5):438-43.

9. Tunalı M, Özdemir H, Küçükodacı Z, Akman S, Yaprak E, Toker H, Fıratlı E. A novel platelet concentrate: titanium-prepared platelet-rich fibrin. Biomed Res Int. 2014; 2014:209548.

10. Chatterjee A, Debnath K, Ali MM, Babu C, Gowda PL. Comparative histologic evaluation of titanium platelet-rich fibrin and platelet-rich fibrin in hypertensive and smoker participants: A cell cytology study. J Indian Soc Periodontol. 2017; 21(3):195-200.

11. Li R, Liu Y, Xu T, Zhao H, Hou J, Wu Y, Zhang D. The Additional effect of autologous platelet concentrates to coronally advanced flap in the treatment of gingival recessions: A systematic review and meta-analysis. Biomed Res Int. 2019;2019:2587245.

12. Chatterjee A, Pradeep AR, Garg V, Yajamanya S, Ali MM, Priya VS. Treatment of periodontal intrabony defects using autologous plateletrich fibrin and titanium platelet-rich fibrin: A randomized, clinical, comparative study. J Investig Clin Dent. 2017; 8(3):12231.

13. Mitra DK, Potdar PN, Prithyani SS, Rodrigues SV, Shetty GP, Talati MA. Comparative study using autologous platelet-rich fibrin and titanium prepared platelet-rich fibrin in the treatment of infrabony defects: An in vitro and in vivo study. J Indian Soc Periodontol. 2019; 23(6):554-61.

14. Gummaluri SS, Bhattacharya HS, Astekar M, Cheruvu S. Evaluation of titanium-prepared platelet-rich fibrin and leucocyte platelet-rich fibrin in the treatment of intra-bony defects: A randomized clinical trial. J Dent Res Dent Clin Dent Prospects. 2020; 14(2):83-91.

15. Reshma AP, Varghese SS, Pampadykandathil LP. Comparison between the regenerative potential of different types of platelet concentrates in periodontal intrabony defect management: A systematic review. J Indian Soc Periodontol. 2022; 26(5):425-33.

16. Oza R, Dhadse P, Bajaj P, Bhombe K, Durge K, Subhadarsanee C, Hassan S. Clinical efficacy of titanium prepared platelet rich fibrin in periodontal regeneration: A systematic review and metaanalysis. F1000Research. 2024; 12(393):393.

17. Salian SS, Dhadse PV. Effectiveness of Titanium Prepared Platelet Rich Fibrin Membrane vs Platelet Rich Fibrin Membrane in the Treatment of Multiple Gingival Recession Defects using M-VISTA Technique: Protocol for a Randomised Clinical Trial. J Clin Diagn Res. 2023; 17(1):ZK08- 11.

18. Özkan Şen D, Öncü E. Splith mouth randomized control trial comparison of T-PRF and subepithelial connective tissue graft in the treatment of maxillar multiple gingival recessions. J Esthet Restor Dent. 2023; 35(3):449-56.

19. Uzun BC, Ercan E, Tunalı M. Effectiveness and predictability of titanium-prepared platelet-rich fibrin for the management of multiple gingival recessions. Clin Oral Investig. 2018; 22(3):1345-54.

20. Pirebas HG, Hendek MK, Kisa U, Yalim M, Erdemir EO. Effect of titanium-prepared plateletrich fibrin treatment on the angiogenic biomarkers in gingival crevicular fluid in infrabony defects of patients with chronic periodontitis: A randomized controlled clinical trial. Niger J Clin Pract. 2018; 21(1):69-75.

21. Koca-Ünsal RB, Ünsal G, Kasnak G, Fıratlı Y, Özcan İ, Orhan K, Fıratlı E. Ultrasonographic evaluation of the titanium-prepared platelet-rich fibrin effect in free gingival graft procedures. J Periodontol. 2022; 93(2):187-94.

22. Ustaoğlu G, Göller Bulut D, Gümüş KÇ. Evaluation of different platelet-rich concentrates effects on early soft tissue healing and socket preservation after tooth extraction. J Stomatol Oral Maxillo fac Surg. 2020; 121(5):539-44.

Recommended Citation

Manchala, B., Teju, A., Pasupuleti, M., Penmetsa, G., Gottumukkala, S., & Lakshmi, V. Role of Titanium-Reinforced Platelet-Rich Fibrin in Periodontal Tissue Regeneration-A Systematic Review. J Dent Indones. 2024;31(2): 74-80