Changing the water solubility property of glass ionomer cement (GIC), which is frequently used in pediatric dentistry, is the starting point of this study. Objective: To evaluate the effects of boric acid on the water solubility (WS) of GIC. Methods: The samples were prepared as n=12 in each of four groups: GIC-Conventional glass ionomer cement; BGIC with 1:3 boric acid added to conventional GIC powder; RMGIC-resin-modified glass ionomer cement; BRMGIC with 1:3 boric acid added to RMGIC powder. Weight changes were compared 1, 3 and 24 h after keeping in distilled water. One sample in each group was measured by SEM-EDX analysis. The data were analyzed using a one-way analysis of variance, Dunnett’s T3 in multiple comparison tests, and generalized linear models. Results: In all groups, water solubility increased. There was a significant difference between the mean values of the WS-1h, WS-3h, and WS-24h variables in each group and between the GIC, BGIC, RMGIC, and BRMGIC groups in the mean values of the WS-1h, WS-3h, and WS-24h variables. The SEM-EDX analysis revealed 14.19–18.47%; 0.80–1.00%; 8.69–14.91%; 0.09–13.10% boron minerals in GIC, BGIC, RMGIC, and BRMGIC, respectively. 8: The addition of boric acid led to an increase in water solubility. The effects of boric acid on the GIC samples emphasized its potential role in altering the cement’s physicochemical properties. Therefore, it is important to consider carefully when using boric acid as a supplement in GIC formulations for dental applications.


1. Mitsuhashi A, Hanaoka K, Teranaka T. Fracture toughness of resin-modified glass ionomer restorative materials: effect of powder/liquid ratio and powder particle size reduction on fracture toughness. Dent Mater. 2003; 19(8):747-57.

2. Moshaverinia A, Ansari S, Moshaverinia M, Roohpour N, Darr JA, Rehman I. Effects of incorporation of hydroxyapatite and fluoroapatite nanobioceramics into conventional glass ionomer cements (GIC). Acta Biomater. 2008; 4(2):432-40.

3. Albers HF. Tooth-colored restoratives: Principles and techniques. 9thed. Hamilton: BC Decker Inc; 2002.

4. Moshaverinia A, Roohpour N, Rehman IU. Synthesis and characterization of a novel fastset proline-derivative-containing glass ionomer cement with enhanced mechanical properties. Acta Biomater. 2009; 5(1):498-507.

5. Gu YW, Yap AU, Cheang P, Khor KA. Effects of incorporation of HA/ZrO(2) into glass ionomer cement (GIC). Biomaterials. 2005; 26(7):713-20.

6. Nicholson JW, Anstice HM, McLean JW. A preliminary report on the effect of storage in water on the properties of commercial light-cured glassionomer cements. Br Dent J. 1992; 173(3):98-101.

7. Küçükeşmen C, Küçükeşmen Ç, Öztaş D, Kaplan R. The effect of water sorption and solubility of different types of conventional and resin-modified glass ionomer cements. Eur Ann Dent Sci. 2005; 32(1):25-34.

8. Lucksanasombool P, Higgs WAJ, Higgs RJED, Swain MV. Toughness of glass fibres reinforced glass-ionomer cements. J Mater Sci. 2002; 37:101- 8.

9. Wang Y, Darvell BW. Hertzian load-bearing capacity of a ceramic-reinforced glass ionomer cement stored wet and dry. Dent Mater. 2009; 25(8):952-5.

10. Gorustovich AA, López JM, Guglielmotti MB, Cabrini RL. Biological performance of boronmodified bioactive glass particles implanted in rat tibia bone marrow. Biomed Mater. 2006; 1(3):100-5.

11. Xie Z, Liu X, Jia W, Zhang C, Huang W, Wang J. Treatment of osteomyelitis and repair of bone defect by degradable bioactive borate glass releasing vancomycin. J Control Release. 2009; 139(2):118-26.

12. Wu C, Miron R, Sculean A, Kaskel S, Doert T, Schulze R, Zhang Y. Proliferation, differentiation and gene expression of osteoblasts in boroncontaining associated with dexamethasone deliver from mesoporous bioactive glass scaffolds. Biomaterials. 2011; 32(29):7068-78.

13. International Organization for Standardization. Dentistry- Polymer-based restorative materials. Switzerland: International Organization for Standardization;2019. ISO 4049:2019;19-21.

14. Biradar B, Biradar S, Ms A. Evaluation of the effect of water on three different light cured composite restorative materials stored in water: An in vitro study. Int J Dent. 2012; 2012:640942.

15. Akgül S. In-vitro evaluation of influence on antibacterial and physical properties of cetrimide and silver nanoparticles incorporation in glass ionomer cement (Doctoral thesis). Konya, Turkey: Selçuk University; 2015.

16. Degrazia FW, Leitune VCB, Samuel SMW, Collares FM. Boron nitride nanotubes as novel fillers for improving the properties of dental adhesives. J Dent. 2017; 62:85-90.

17. Institute of Medicine (US) Panel on Micronutrients. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington (DC): National Academies Press (US); 2001.

18. World Health Organization. Boron. In: Trace elements in human nutrition and health. Geneva: World Health Organization; 1996. p.175-9.

19. World Health Organization. International programme on chemical safety. In: Environmental health criteria 204 boron. Geneva: World Health Organization; 1998. p.9.

20. European Food Safety Authority. Opinion of the scientific panel on dietetic products, nutrition and allergies on a request from the commission related to the tolerable upper intake level of boron (sodium borate and boric acid). EFSA J. 2004; 80:1-22.

21. Ahmed MH, Yoshihara K, Yao C, Okazaki Y, Van Landuyt K, Peumans M, Van Meerbeek B. Multiparameter evaluation of acrylamide HEMA alternative monomers in 2-step adhesives. Dent Mater. 2021; 37(1):30-47.

22. Mustafa R, Alshali RZ, Silikas N. The effect of desiccation on water sorption, solubility and hygroscopic volumetric expansion of dentine replacement materials. Dent Mater. 2018; 34(8):e205-13.

23. Ito S, Hoshino T, Iijima M, Tsukamoto N, Pashley DH, Saito T. Water sorption/solubility of selfetching dentin bonding agents. Dent Mater. 2010; 26(7):617-26.

24. Prentice LH, Tyas MJ, Burrow MF. The effects of boric acid and phosphoric acid on the compressive strength of glass-ionomer cements. Dent Mater. 2006; 22(1):94-7.

25. Bochek AM, Yusupova LD, Zabivalova NM, Petropavlovskii GA. Rheological properties of aqueous H-carboxymethyl cellulose solutions with various additives. Russ J Appl Chem. 2002; 75(4):645-48.

26. Sevilmis HH, Bulucu B. Water absorption properties of adhesive materials. Clin Dent Res J. 2007; 31(2):16-21.

27. Olcay K, Ataoğlu H, Belli S. Analysis of mineral content of the teeth extracted for endodontic reasons using with SEM-EDX method. Selcuk Dent J. 2016; 3(3):107-19.

28. Bijle MN, Ekambaram M, Lo ECM, Yiu CKY. Antibacterial and mechanical properties of arginine-containing glass ionomer cements. Dent Mater. 2020; 36(9):1226-40.

29. Borges RP, Sousa-Neto MD, Versiani MA, Rached-Júnior FA, De-Deus G, Miranda CE, Pécora JD. Changes in the surface of four calcium silicate-containing endodontic materials and an epoxy resin-based sealer after a solubility test. Int Endod J. 2012; 45(5):419-28.

30. Saridena USNG, Sanka GSSJ, Alla RK, Ramaraju AV, Sajjan MCS, Mantena SR. An overview of advances in glass ionomer cements. Int J Dent Mater. 2022; 4(4): 89-94.



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