•  
  •  
 

Abstract

Introduction. Depression is a mental disorder that is often found in the elderly and hemodialysis patients, resulting in bad effects on patients. There is no study on the relationship between depression and all-cause mortality risk in elderly hemodialysis patients in Indonesia. This study aimed to determine the role of depression as a predictor factor of all-cause mortality within 6 months in elderly hemodialysis patients. Methods. A prospective cohort study was conducted from February to August 2020 at the hemodialysis unit of Roemani Muhammadiyah Hospital, Semarang. The inclusion criteria were elderly patients (aged ≥60 years), undergoing hemodialysis ≥3 months, hemodialysis frequency twice a week, willing to participate in this study, able to communicate well, and has no history of mental disorders include a history of psychotic disorders and mental disorders due to substance use. Meanwhile, patients whose data were incomplete, transferred to another hemodialysis unit, HBsAg +, hemoglobin level /dl. FRAILTY score >2, and had other stressors not related to hemodialysis or chronic kidney disease (CKD) such as social, family, and work factors were excluded from this study. Depression was assessed using the Beck Depression Inventory-II questionnaire. The collected data was then analyzed using Kaplan Meier and Cox Regression.Results. Of 32 respondents, most of them were male (81.3%). The mean age was 67.2 (SD 7) years. There were 6 (18.7%) respondents categorized into a depression group and 26 (81.3%) respondents into a non-depression group. Cox Regression analysis showed that depression was a predicting factor of all-cause mortality within six months in elderly hemodialysis patients (p value=0.012, and Hazard ratio=10.149). Conclusion. Depression is a predictor factor of all-cause mortality within six months in elderly hemodialysis patients.

References

1. Widiana GR, Kandarini Y, Suardana K, Suka N. Terapi dialisis buku pegangan untuk dokter dan perawat dialisis. Edisi 2. Denpasar: Udayana University Press; 2017. 2. Anissa M, Amelia R, Dewi NP. Gambaran tingkat depresi pada lansia di wilayah kerja Puskesmas Guguak Kabupaten 50 Kota Payakumbuh. Heal Med J. 2019;1(2):12–6.3. de Alencar SBV, de Lima FM, Dias LDA, Dias VDA, Lessa AC, Bezerra JM, et al. Depression and quality of life in older adults on hemodialysis. Brazilian J Psychiatry. 2020;42(2):195–200. 4. Setiati S. Geriatric medicine, sarcopenia, frailty and geriatric quality of life: future challenge in education, research and medical service in Indonesia. eJKI. 2013;1(3):234–42. 5. Deza-Araujo YI, Baez-Lugo S, Vuilleumier P, Chocat A, Chételat G, Poisnel G, et al. Whole blood serotonin levels in healthy elderly are negatively associated with the functional activity of emotion-related brain regions. Biol Psychol. 2021;2021:160. 6. Wu PH, Lin MY, Huang TH, Lin YT, Hung CC, Yeh YC, et al. Depression amongst patients commencing maintenance dialysis is associated with increased risk of death and severe infections: A nationwide cohort study. PLoS One. 2019;14(6):1–15. 7. Corrêa VP, Confortin SC, d’Orsi E, de Sá-Junior AR, de Oliveira C, Schneider IJC. Depressive symptoms as an independent risk factor for mortality. Rev Bras Psiquiatr. 2021;43(3):247–53. 8. Hannan JL, Radwany SM, Albanese T. In-hospital mortality in patients older than 60 years with very low albumin levels. J Pain Symptom Manage. 2012;43(3):631–7. 9. Fujii H. Association between parathyroid hormone and cardiovascular disease. Ther Apher Dial. 2018;22(3):236–41.10. Sorayah S. Uji validitas konstruk beck depression inventory -II (BDI-II). J Pengukuran Psikologi dan Pendidikan Indones. 2015;4(3):29–46. 11. Alwi I. Kriteria empirik dalam menentukan ukuran sampel. Form J Ilm Pendidik MIPA. 2012;2(2):140–8. 12. PERNEFRI. 11th Report of indonesian renal registry 2018. Jakarta: PERNEFRI; 2018. hal.1–46. 13. Davison SN, Levin A, Moss AH, Jha V, Brown EA, Brennan F, et al. Executive summary of the KDIGO Controversies Conference on Supportive Care in Chronic Kidney Disease: Developing a roadmap to improving quality care. Kidney Int. 2015;88(3):447–59. 14. Perdhana L, Mupangati YM, Chasani S, Nuraini S. Prevalensi dan faktor – faktor yang mempengaruhi depresi pada pasien lansia yang menjalani hemodialisis di Rumah Sakit Roemani Muhammadiyah Semarang [Prosiding]. Temu Ilmiah Geriatri 2020, Frailty: A to Z. Jakarta: Pengurus Besar Perhimpunan Gerontologi Medik Indonesia; 2020. hal.253–4. 15. Lee H-S, Chao H-H, Huang W-T, Chen SC-C, Yang H-Y. Psychiatric disorders risk in patients with iron deficiency anemia and association with iron suppplementation medication : a nationwide database analysis. BMC Psychiatry. 2020;20(1):216. 16. Pernefri. Konsensus Manajemen anemia pada penyakit ginjal kronik. Vol. 53. Jakarta: Perhimpunan Nefrologi Indonesia; 2011. hal.1689–99. 17. Noorazar SG, Ranjbar F, Nemati N, Yasaminch N, Kalejahi P. Relationship between severity of depression symptoms and iron deficiency anemia in women with major depressive disorder. J Anal Res Clin Med. 2015;3(4):219–24. 18. Cowen PJ, Browning M. What has Seotonin to do with depresssion? World Psychiatry. 2015;14(2):158–60. 19. Tuǧcu M, Kasapoǧlu U, Şahin G, Apaydin S. The factors affecting survival in geriatric hemodialysis patients. Int J Nephrol. 2018;2018:1-4. 20. Song YH, Cai GY, Xiao YF, Chen XM. Risk factors for mortality in elderly haemodialysis patients: A systematic review and meta-analysis. BMC Nephrol. 2020;21(1):1–10. 21. Singh S, Bajorek B. Definiendo ‘anciano’ en las guías de práctica clínica para farmacoterapia. Pharm Pract (Granada). 2014;12(4):1–9.22. Kementerian Kesehatan Republik Indonesia. Permenkes No. 67 tahun 2015 tentang penyelenggaraan pelayanan kesehatan lanjut usia di pusat kesehatan masyarakat. Jakarta: Kementerian Kesehatan Indonesia; 2015. 23. John S, Mcculloch CE, Johansen KL. Depressive symptoms, frailty, and mortality among dialysis patients. Physiol Behav.2019;176(3):139–48. 24. May HT, Horne BD, Knight S, Knowlton KU, Bair TL, Lappé DL, et al. The association of depression at any time to the risk of death following coronary artery disease diagnosis. Eur Hear J - Qual Care Clin Outcomes. 2017;3(4):296–302.25. Ahmadi SM, Keshavarzi S, Refahi Z, Lankarani KB. Dependence of the geriatric depression scores on nutritional status, cognitive abilities and anthropometric indices in elderly population of Shiraz, Iran. Iran J Psychophysiol. 2013;8(2):92–6.

Download

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.