•  
  •  
 

Abstract

Drug allergy is a serious medical problem. Drug allergy can be defined as an adverse drug reaction involving immunological mechanism. However, it is not easy to decide whether an adverse drug reaction is an allergic reaction, and it requires a systematically diagnostic approach. Beside a thorough history taking and physical examination, there are general and specific laboratory examination to investigate drug allergy which can be done in vivo, in vitro, or biopsy. The management of drug allergy include the avoidance of the precipitating event, and specific methods to reduce the drug reaction which include threating through, dosing test, desensitization, and the administration of premedication for certain drugs.

References

1. Sadreddini HA, Starkey ES. Drug allergy:diagnosis and managemen tofdrug allergyin adults, children and young people; a look at NICE guidance. London:National Institute for Health and Care Excellence (UK);2014. 2. Baratawidjaja, KG., Rengganis, Iris. Alergi Dasar Edisi ke-10. Jakarta: FKUI; 2009.hal.459-92. 3. Liebhart J,Dobek R,Małolepszy J, et al. ThePrevalenceof Allergic Diseases in Poland - the Results of the PMSEAD Study in Relation to Gender Differences. Adv Clin Exp Med.2014;23(5):757-62. 4. Sangasapasviliya A,Prakongwong T, Ayuthaya PK. Drug hypersensitivity in Phramongkutklao Hospital. J Med Assoc Thai.2010;93(Suppl 6):S106-11. 5. Bourke J,Pavlos R,James I, Phillips E. Improving the Effectiveness of Penicillin Allergy De-labeling. J Allergy Clin Immunol Pract.2015;3(3):334-84. 6. Gamboa PM. The epidemiology of drug allergy-related consultations in Spanish Allergology Services: Alergológica-2005. J Investig Allergol Clin Immunol. 2009;19(Suppl2):45-50. 7. England RW, Ho TC, Napoli DC, Quinn JM. Inpatient consultation of allergy/immunology in a tertiary care setting. Ann Allergy Asthma Immunol. 2003;90(4):393-7. 8. The Hacettepe Method is an efficient, safe and cost effective method of drug allergy work-up. Fuat Kalyoncu A. Allergol Immunopathol (Madr).2015;43(1):103-4 9. Warrington R, Silviu-Dan F. Drug allergy. Allergy Asthma Clin Immunol. 2011;7(Suppl 1):S10. 10. Khan DA, Solensky R: Drug allergy. J Allergy Clin Immunol. 2010;125(2 Suppl 2):S126-37. 11. Pichler WJ, Naisbitt DJ, Park BK. Immune pathomechanism of drug hypersensitivity reactions. J Allergy Clin Immunol. 2011;127(Suppl):S74-81. 12. McKinnon RP, Wildsmith JA. Histaminoid reactions in anaesthesia. Br J Anaesth. 1995;74:217-28. 13. Posadas SJ, Pichler WJ. Delayed drug hypersensitivity nreactions - new concepts. Clin Exp Allergy. 2007;37(7):989-99. 14. Sanderson JP, Naisbitt DJ, Farrell J, Ashby CA, Tucker MJ, Rieder MJ, et al. Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling. J Immunol. 2007;178(9):5533-42. 15. Barranco P, Lopez-Serrano MC: General and epidemiological aspects of allergic drug reactions. Clin Exp Allergy. 1998;28(Suppl 4):61-2. 16. Thong BY, Tan TC. Epidemiology and risk factors fordrug allergy.Br J Clin Pharmacol. 2011;71(5):684-700. 17. Joint Task Force on Practice Parameters; American Academy of Alergy, Asthma and Immunology; American College of Allergy, Asthma and Immunology; Joint Council of Allergy, Asthma and Immunology. Drug allergy: an updated practice parameter. Ann Allergy Asthma Immunol. 2010;105(4):259-73. 18. McKenna JK, Leiferman KM. Dermatologic drug reactions. Immunol Allergy Clin North Am. 2004;24(3):399–423. 19. Roujeau JC. Clinical heterogeneity of drug hypersensitivity. Toxicology. 2005;209(2):123–9. 20. Ooi BS, Pesce AJ, First MR, et al. IgE levels in interstitial nephritis. Lancet.1974;303(7869):1254–6. 21. Sogn DD, Evans R, Shepherd GM, et al. Results of the National Institute of Allergy and Infectious Diseases collaborative clinical trial to test the predictive value of skin testing with major and minor penicillin derivatives in hospitalized adults. Ann Intern Med. 1992;152(5):1025–32. 22. Lieberman P, Nicklas RA, Oppenheimer J, et al. The diagnosis and management of anaphylaxis: 2010 Update. J Allergy Clin Immunol. 2010;126(3):477–80. 23. Frew A. Generalprinciples ofinvestigatingand managingdrug allergy. Br J Clin Pharmacol. 2011;71(5):642-6. 24. Sullivan TJ, Yecies LD, Shatz GS, et al. Desensitization of patients allergic to penicillin using orally administered beta-lactam antibiotics. J Allergy Clin Immunol. 1982;69(3):275–82. 25. Solensky R. Drug desensitization. Immunol Allergy Clin North Am. 2004;24(3):425–43. 26. Harris AD, Sauberman L, Kabbash L, et al. Penicillin skin testing: a way to optimize antibiotic utilization. Am J Med. 1999;107)2):166–8.

Download

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.