Abstract
Introduction. Coronavirus Disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) which in 2020 was declared a global pandemic. In the management of COVID-19, patients are classified according to the severity. Identifying prognostic factors at an early stage helps assess severity risks. Abnormal hematological parameters were present in COVID-19 patients such as the elevation of neutrophil lymphocyte ratio (NLR) and D-dimer patients. This study aimed to determine the NLR and D-dimer levels based on the severity of COVID-19 patients.
Methods. This study was an observational analytical study that used a case-control approach using 100 medical records of COVID-19 patients who were treated at Semen Padang Hospital in 2021. Consecutive sampling was used in this study. ANOVA test and the Kruskal-Wallis test were used for bivariate analysis. The results were considered significant if the p-value <0.05.
Results. Characteristics of patients treated for COVID-19 were: 51% male and 49% female, mean age 57.79 (SD 13.5) years. NLR values based on the severity (mild, moderate, severe, and critical) were 3.12 (SD 2.04), 3.51 (SD 2.87), 6.89 (SD 3.6), 12.57 (SD 10.34) respectively; p<0.05. The median value of D-dimer (ng/mL) based on the severity (mild, moderate, severe, and critical) were 444, 791, 1,610, 2,135; p<0.05. The results of this study showed that there were significant differences in the NLR values and D-dimer levels based on severity.
Conclusion. RNL value and D-dimer levels increase the most in the critical degree group and shows a significant relationship in COVID-19 patients.
Bahasa Abstract
Pendahuluan. Coronavirus Disease 2019 (COVID-19) disebabkan oleh Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) yang pada tahun 2020 ditetapkan sebagai pandemi global. Dalam penatalaksanaan COVID-19, pasien dikelompokkan sesuai derajat keparahan. Mengidentifikasi faktor prognostik di awal sangat membantu untuk menilai risiko derajat keparahan. Beberapa parameter hematologi abnormal ditemukan pada pasien COVID-19 seperti peningkatan rasio neutrofil limfosit (RNL) dan kadar D-dimer. Penelitian ini bertujuan untuk mengetahui nilai RNL dan kadar D-dimer berdasarkan derajat keparahan pasien COVID-19.
Metode. Penelitian ini merupakan penelitian analitik observasional dengan pendekatan kasus kontrol menggunakan 100 data rekam medis pasien COVID-19 yang dirawat di Rumah Sakit Semen Padang pada tahun 2021. Teknik pengambilan sampel adalah consecutive sampling. Analisis bivariat menggunakan uji One-Way ANOVA dan uji Kruskal-Wallis. Hasil dianggap bermakna jika nilai p<0,05.
Hasil. Karakteristik pasien rawatan COVID-19 yaitu terdiri dari laki-laki sebanyak 51% dan perempuan 49% dengan rerata usia 57,79 [simpang baku (SB) 13,5) tahun. Nilai RNL berdasarkan derajat keparahan (ringan, sedang, berat, dan kritis) masing-masing adalah 3,12 (SB 2,04), 3,51 (SB 2,87), 6,89 (SB 3,6), 12,57 (SB 10,34); p<0,05. Sedangkan, median kadar D-dimer (ng/mL) pada masing-masing derajat keparahan tersebut adalah 444, 791, 1.610, 2.135 (p<0,05). Hasil penelitian ini menunjukkan terdapat perbedaan yang bermakna nilai RNL dan kadar D-dimer berdasarkan derajat keparahan.
Simpulan. Nilai RNL dan kadar D-dimer paling meningkat pada kelompok derajat kritis dan menunjukkan hubungan yang bermakna pada pasien COVID-19.
Kata Kunci: COVID-19, D-dimer, RNL
Recommended Citation
Besri, Hanifa Zahra; Efrida, Efrida; Jurnalis, Yusri Dianne; Putra, Andani Eka; Fitrina, Dewi Wahyu; and Husni, Husni
(2023)
"Rasio Neutrofil Limfosit dan Kadar D-Dimer berdasarkan Derajat Keparahan Pasien COVID-19 di Rumah Sakit Semen Padang : Studi Kasus Kontrol,"
Jurnal Penyakit Dalam Indonesia: Vol. 10:
Iss.
2, Article 4.
DOI: 10.7454/jpdi.v10i2.1451
Available at:
https://scholarhub.ui.ac.id/jpdi/vol10/iss2/4