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Abstract

Ameloblastic fibrodentinoma (AFD) is a rare tumor with an incidence rate of less than 1%. When lesion with the histomorphology of ameloblastic fibroma(AF), which is true neoplasms, form dysplastic dentin, and had been referred to as AFD. It histologically consists of odontogenic ectomesenchyme resembling the dental papilla, epithelial strands, and nests resembling dental lamina and enamel organ with dentin formation. Although newly categorized as an odontoma by the WHO in 2017, this lesion was previously referred to as a rare odontogenic tumor by the WHO in 2005. Objective: We aim to summarize our case with other previous case reports considered to be equivalent to the conventional WHO classification of AFD. Case Report: An 8-year-old girl presented to our hospital complaining of delayed eruption of a tooth. Computed tomography showed an odontoma-like radiopacity in a unilocular radiolucent lesion sized approximately 20 mm. The lesion was extracted under general anesthesia and histopathologically exhibited AFD. Herein, we report a rare case of AFD in the maxilla. Conclusion: Although this lesion deviates from the concept of disease as an odontogenic tumor, it is hoped that clinically sufficient follow-up is required and more similar cases will accumulate as independent tumors, rather than simply being recognized as developmental odontomas.

References

1. Slootweg PJ . Ameloblastic Fibroma/ Fibrodentinoma. WHO Classification of Tumours. Pathology & Genetics, Head and Neck Tumours. IARC Press. 2005; 308.

2. Muller S, Vered M, et al. Ameloblastic fibroma. WHO Classification of Tumours Head and Neck Tumours. IARC Press. 2017;223.

3. Straith FE. Odontoma: A rare type. Report of a case. Dent Dig. 1936;42:196.

4. Lukin maa PL, Hietanen J, Laitinen J M, Malmström M. Mandibular dentinoma. J Oral Maxillofac Surg. 1987;45(1):60-4.

5. Anker AH, Radden BG. Dentinoma of the mandible. Oral Surg Oral Med Oral Pathol, 1989;67(1):731-3.

6. Takeda Y. So-called “immature dentinoma”: A case presentation and histological comparison with ameloblastic fibrodentinoma. J Oral Pathol Med. 1994;23:92-6.

7. Kokuryo S, Tominaga K, Habu M, Zhang M, Fukuyama H, Fukuda J. A case of ameloblastic fibrodentinoma in the anterior maxilla. Jpn J Oral Maxillal Surg. 2009;55(7):364-8.

8. Sabu AM, Gandhi S, Singh I, Solanki M, Sakharia A R. Ameloblastic fibrodentinoma: A rarity in odontogenic tumors. J Maxillofac Oral Surg. 2018;17(4):444-8.

9. Bhargava D, Dave A, Sharma B, Nanda KD. Ameloblastic fibrodentinoma. Indian J Dent Res. 2011; 22(2):345-7.

10. Minamizato T, Takasi I, Ikeda H, Fujita S, Asahina I. Peripheral-type ameloblastic fibrodentinoma with features of so-called ‘‘immature dentinoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;117(1):e61-4.

11. Joseph S, Priya L, Gopal D, Devachen M, Narayan A, Afnan M. Ameloblastic fibrodentinoma presenting as a false gingival enlargement in the maxillary anterior region. Case Rep Dent. 2015;812087.

12. Bhargava M, Sood S, Rathore P. Ameloblastic fibrodentinoma: Report of a case in an infant. J Clin Diagn Res. 2016;10(1):ZD06-7.

13. Takahashi K, Eda T, Tajima M, Okudaira Y, Watanabe S, Kato Y et al. A case of ameloblastic fibrodentinoma in the posterior mandible. Int J Oral-Med Sci. 2019;18(1):123-6.

14. Bavle RM, Muniswammappa S, Venugopal R, R AS. Ameloblastic fibrodentinoma: A case with varied patterns of dysplastic dentin. Cureus. 2017;9(6):e1349.

15. Kaur V, Tilakraj TN. Peripheral ameloblastic fibrodentinoma in a 3-year-old boy: Report of an unusual and rare case. J Oral Maxillofac Pathol. 2018;22(1):112-5.

16. Giraddi GB, Garg V. Aggressive atypical ameloblastic fibrodentinoma: Report of a case. Contemp Clin Dent. 2012;3(1):97-102.

17. Bologna-Molina R, Salazar-Rodríguez S, Bedoya- Borella AM, Carreón-Burciaga RG, Tapia-Repetto G, Molina-Frechero N. A histopathological and immunohistochemical analysis of ameloblastic fibrodentinoma. Case Rep Pathol. 2013;604560.

18. Takeda Y, Sato H, Satoh M, Nakamura SI, Yamamoto H. Immunohistochemical expression of neural tissue markers (neuron-specific enolase, glial fibrillary acidic protein, S100 protein) in ameloblastic fibrodentinoma: A comparative study with ameloblastic fibroma. Pathol Int. 2000;50(8):610-5.

19. Nagori SA, Jose A, Bhutia O, Roychoudhury A. Ameloblastic fibrosarcoma developing 8 years after resection of ameloblastic fibro-dentinoma: A unique presentation. J Oral Maxillofac Surg Med Pathol. 2015;27:143-6.

20. Howell RM, Burkes EJ Jr. Malignant transformation of ameloblastic fibro-odontoma to ameloblastic fibrosarcoma. Oral Surg Oral Med Oral Pathol. 1977;43(3):391-401.

21. Agarwal P, Kothari N, Girdhar M.A case report of peripheral-type ameloblastic fibrodentinoma and a review. Br J Med Res. 2015;8(10):891-5.

22. Chrcanovic BR, Gomez RS. Ameloblastic fibrodentinoma and ameloblastic fibro-odontoma: An updated systematic review of cases reported in the literature. J Oral Maxillofac Surg. 2017;75(7):1425-37.

23. Ahmed M, Sadat SMA, Rita SN. Ameloblastic fibro-dentinoma of mandible: A case report. J Bangladesh Coll Phys Surg. 2006;24:119-21.

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