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Abstract

non-diabetes mellitus population. However, it’s effect on PTB in type 2 diabetes mellitus (T2DM) patient is unclear. The study aims to determine the association between obesity and PTB in patient with T2DM. A cross sectional study was held in in-patient, The Department of Internal Medi cine, Fatmawati General Hospital from January 2015 to December 2017. This study includes patient with T2DM who had been diagnosed with PTB and age > 18 years old. In this study negative Acid-fast-bacilli (AFB) founding defined as patient’s sputum is negative by smear microscopy, while obesity define as body mass index > 24.9 kg/m2. From 363 PTB patient with T2DM, 22.59% were obese. Results showed that prevalence of negative AFB founding in PTB patients with T2DM was 81.82% and it was solely associated with obesity (p:0.002, OR=6.36, 95%CI 1.9-21). Obese patients were likely to have negative AFB founding. It suggested that diagnosing PTB in patient with T2DM and obese can’t be solely based on bacteriological confirmation.

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Bahasa Abstract

Obesitas merupakan faktor protektif terhadap terjadinya tuberculosis paru (TB Paru) pada populasi non-diabetes. Namun, pengaruh obesitas pada pasien dengan diabetes melitus tipe II (DMT2) belum banyak diketahui. Studi ini bertujuan untuk mengetahui hubungan obesitas dan TB Paru pada pasien dengan DMT2. Studi merupakan studi potong lintang yang dilakukan di instalasi rawat inap, Departemen Penyakit Dalam, Rumah Sakit Umum Pusat Fatmawati pada bulan Januari 2015 sampai dengan Desember 2017. Kriteria inklusi pada penelitian ini adalah pasien DMT2 yang telah terdiagnosa dengan TB paru dan berusia > 18 tahun. Pada studi ini, hasil Bakteri Tahan Asam (BTA) negative didefinisikan sebagai tidak ditemukannya BTA pada pemeriksaan mikroskopik sputum subjek, sementara obesitas didefinisikan sebagai index massa tubuh > 24.9 kg/ m2. Dari 363 subjek dengan TB paru dan DMT2, 22.59% subjek mengalami obesitas. Prevalensi BTA negative pada pasien dengan TB paru dan DMT2 adalah 81.82%, temuan tersebut diketahui berhubungan dengan kejadian obesitas (p:0.002, OR=6.36, 95%CI 1.9-21). Kesimpulan dari penelitian ini adalah pada pasien TB paru dan DMT2 dengan obesitas, hasil pemeriksaan sputum cenderung memberikan hasil negative. Oleh karena, itu perlu kewaspadaan dalam mendiagnosa TB paru pada pasien dengan DMT2 yang mengalami obesitas, karena tidak dapat semata mata disingkirkan hanya berdasarkan hasil pemeriksaan sputum.

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