ORCID ID
Ambika Rani Yadav: 0009-0008-6366-592X
Priya Keshari: 0000-0001-8952-5660
Abstract
Background: Hypercholesterolemia is an abnormality of lipids. It is a crucial modifiable risk factor for cardiovascular diseases. There is a paucity of community-based studies on hypercholesterolemia in the adult population in India. Given this context, the study aims to assess the prevalence and spectrum of hypercholesterolemia, along with its associated factors, among adult residents of urban areas in Prayagraj district, Uttar Pradesh, India.
Methods: This community-based cross-sectional study was done on 536 urban adult subjects (30 to 59 years) of Prayagraj, India, selected by multistage sampling procedure. The predesigned and pretested interview schedule was used to obtain socio-demographic information about subjects. Nutritional parameters and serum cholesterol were assessed using the standard procedure. Statistical analysis was done using the Statistical Package for Social Sciences. The chi-square test and logistic regression analysis were done for association and inferential purposes, respectively.
Results: The prevalence of Hypercholesterolemia was 24.4%. This was significantly (p < 0.05) higher in subjects aged 50-59 years, family size 2-4, and having higher body mass index, waist circumference, and visceral fat%. Age emerged as a significant predictor of hypercholesterolemia.
Conclusions: One out of 4 urban subjects had hypercholesterolemia. This study emphasizes the need for age-specific screening and preventive and promotive services to reduce hypercholesterolemia.
References
- GBD 2013 Mortality and Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;385:117–71.
- Jung E, Kong SY, Ro YS, Ryu HH, Shin SD. Serum cholesterol levels and risk of cardiovascular death: A systematic review and a dose-response meta-analysis of prospective cohort studies. Int J Environ Res Public Health. 2022;19:8272.
- Chandra KS, Bansal M, Nair T, Iyengar SS, Gupta R, Manchanda SC, et al. Consensus statement on management of dyslipidemia in Indian subjects. Indian Heart J. 2014;66 Suppl 3:S1–51.
- Joshi SR, Anjana RM, Deepa M, Pradeepa R, Bhansali A, Dhandania VK, et al. Prevalence of dyslipidemia in urban and rural India: The ICMR-INDIAB study. PLoS One. 2014;9:e96808.
- Gupta R, Rao RS, Misra A, Sharma SK. Recent trends in epidemiology of dyslipidemias in India. Indian Heart J. 2017;69:382–92.
- Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2019;73:3168–209.
- Benjamin EJ, Virani SS, Callaway CW, Chamberlain AM, Chang AR, Cheng S, et al. Heart Disease and Stroke Statistics-2018 Update: A Report From the American Heart Association. Circulation. 2018;137:e67–492.
- Adeloye D, Abaa DQ, Owolabi EO, Ale BM, Mpazanje RG, Dewan MT, et al. Prevalence of hypercholesterolemia in Nigeria: A systematic review and meta-analysis. Public Health. 2020;178:167–78.
- Reddy KS, Prabhakaran D, Chaturvedi V, Jeemon P, Thankappan KR, Ramakrishnan L, et al. Methods for establishing a surveillance system for cardiovascular diseases in Indian industrial populations. Bull World Health Organ. 2006;84:461–9.
- Kinra S, Bowen LJ, Lyngdoh T, Prabhakaran D, Reddy KS, Ramakrishnan L, et al. Sociodemographic patterning of non-communicable disease risk factors in rural India: A cross sectional study. BMJ. 2010;341:c4974.
- Pandey RM, Gupta R, Misra A, Misra P, Singh V, Agrawal A, et al. Determinants of urban-rural differences in cardiovascular risk factors in middle-aged women in India: A cross-sectional study. Int J Cardiol. 2013;163:157–62.
- Shah B, Mathur P. Surveillance of cardiovascular disease risk factors in India: The need & scope. Indian J Med Res. 2010;132:634–42.
- Guptha S, Gupta R, Deedwania P, Bhansali A, Maheshwari A, Gupta A, et al. Cholesterol lipoproteins and prevalence of dyslipidemias in urban Asian Indians: A cross sectional study. Indian Heart J. 2014;66:280–8.
- Majhi MM, Mishra CP, Mishra SP. Elevated blood triglycerides and its predictors in rural adult population: Findings from central India. Int J Sci Res. 2019;8:56–8.
- Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA. 2001;285:2486–97.
- Goodman DS. The National Cholesterol Education Program: Guidelines, status, and issues. Am J Med. 1991;90:32S–35.
- FindEasy. Uttar Pradesh Population 2024. India: FindEasy, 2021.
- Park K. Park's textbook of preventive and social medicine. 27th ed. Madhya Pradesh, India: Banarsidas Bhanot; 2023.
- Ananthan VA. Modified Kuppuswamy scale for socioeconomic status of the Indian family- Update based on New CPI (IW) series from September 2020. J Family Med Prim Care. 2021;10:2048–9.
- World Health Organization. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser. 2000;894:i–xii, 1–253.
- Nagamine S. Diagnosis of obesity from subcutaneous fat deposition. J Japan Med Assoc. 1972;68:919.
- Lohmann TG, Roche AF, Martorell R. Anthropometric Standardization Reference Manual. Champaign, IL, USA: Human Kinetics Books; 1988.
- Li LH, Dutkiewicz EP, Huang YC, Zhou HB, Hsu CC. Analytical methods for cholesterol quantification. J Food Drug Anal. 2019;27:375–86.
- Zhang M, Wang LM, Chen ZH, Zhao ZP, Li YC, Deng Q, et al. 2013年中国不同区域成人高胆固醇血症流行水平及相关因素分析 [Multilevel logistic regression analysis on hypercholesterolemia related risk factors among adults in China]. Zhonghua Yu Fang Yi Xue Za Zhi. 2018;52:151–7. Chinese.
- Sarfraz M, Sajid S, Ashraf MA. Prevalence and pattern of dyslipidemia in hyperglycemic patients and its associated factors among Pakistani population. Saudi J Biol Sci. 2016;23:761–6.
- Al-Mahmood AAS, Al-Sharifi EAH, Al-Mahmood AAA. Epidemiology of hypercholesterolemia among adults in Samara City. Indian J Public Health Res Dev. 2020;11:909–14.
- Gamit DN, Mishra A. A lipid profile study amongst the patients of type 2 diabetes mellitus – A cross sectional study. Int Arch Integr Med. 2018;5:1–5.
- Aslesh OP, Jayasree AK, Karunakaran U, Venugopalan AK, Divakaran B, Mayamol TR, et al. Prevalence of hypercholesterolaemia among adults aged over 30 years in a rural area of north Kerala, India: A cross-sectional study. WHO South East Asia J Public Health. 2016;5:70–5.
- Bali K, Vij AS. Pattern of dyslipidemia in type 2 diabetes mellitus in Punjab. Int J Res Med Sci. 2016;4:809–12.
- Singh Y, Vohra DK, Khan MM, Singh G. Prevalence of dyslipidemia in newly diagnosed patients of type-2 diabetes mellitus at tertiary care centre of West Uttar Pradesh: A single centre study. Panacea J Med Sci. 2019;9:33–6.
- Raj SA, Sivakumar K, Sujatha K. Prevalence of dyslipidemia in South Indian adults: An urban-rural comparison. Int J Community Med Public Health. 2016;3:2201–10.
- United Nations. The Millennium Development Goals Report 2014. New York, United States: United Nations, 2014.
- United Nations. World urbanization prospects: The 2014 revision. New York, United States: United Nations, 2015.
- Patil RR. Urbanization as a determinant of health: A socioepidemiological perspective. Soc Work Public Health. 2014;29:335–41.
- Al-Hassan YT, Fabella EL. Lipid profile analysis of patients in a Saudi university clinic. World J Public Health. 2017;2:89–95.
- Sukkriang N, Chanprasertpinyo W, Wattanapisit A, Punsawad C, Thamrongrat N, Sangpoom S. Correlation of body visceral fat rating with serum lipid profile and fasting blood sugar in obese adults using a noninvasive machine. Heliyon. 2021;7:e06264.
- Ranganathan S, Krishnan T, Radhakrishnan S. Comparison of dyslipidemia among the normal-BMI and high-BMI group of people of rural Tamil Nadu. Med J Dr. DY Patil Univ. 2015;8:149–52.
- Luo Y, Ma X, Shen Y, Hao Y, Hu Y, Xiao Y, et al. Positive relationship between serum low-density lipoprotein cholesterol levels and visceral fat in a Chinese nondiabetic population. PLoS One. 2014;9:e112715.
Recommended Citation
Yadav AR, Keshari P. Threat of Hypercholesterolemia in Urban Adults and Its Associates: Evidence from a Community-Based Study. Makara J Health Res. 2024;28.
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