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ORCID ID

Kiran Ganesh Balakrishnan : 0009-0004-6430-019X

Mohd Rizal Abd Manaf : 0000-0002-0813-8376

Mohd Rohaizat Hassan : 0000-0002-4658-6532

Mohd Kamarul Imran Musa : 0000-0002-3708-0628

Azizul Rahman Mohamad Jamil : 0009-0008-8414-8200

Norhaslira Abdul Rahim : 0009-0006-4688-9281

Umi Kalsom Satariah Ali : 0000-0002-4421-3724

Rahman Jamal : 0000-0002-8354-8957

Abstract

Background: Influenza infection can lead to mortality and morbidity. In densely populated Kuala Lumpur, Malaysia, the transmission of influenza-like illness (ILI) is high. This study assessed the prevalence and epidemiology of influenza in the target population.

Methods: A cross-sectional convenience sample study was conducted in government clinics of Cheras, Malaysia, from November 1, 2022, to February 28, 2023. Consent was sought from patients older than 18 years with symptoms of ILI (fever, cough, and onset within 10 days). A nasopharyngeal swab preceded an influenza rapid test. Logistic regression was used in SPSS 22.0 to evaluate the data.

Results: Among 438 patients, 55 (12.6%) tested positive for influenza type B, 9 (2%) tested positive for type A, and 374 (85.4%) were negative. Patients in the group that was 10 years older than the younger group had 1.47 times the odds of having influenza. The odds of positive influenza rose 1.133 times per unit of body mass index (BMI). Patients with chronic lung illness were 6.7 times (95% confidence interval, 2.742–16.287) more likely to test positive for influenza. Sex and smoking history did not affect the rate of influenza infection (p > 0.05).

Conclusions: An association was found between age, BMI, and chronic lung disease with influenza infection but not with sex or smoking.

References

  1. Iuliano AD, Roguski KM, Chang HH, Muscatello DJ, Palekar R, Tempia S, et al. Estimates of global seasonal influenza-associated respiratory mortality: A modelling study. Lancet. 2018;391:1285–300.
  2. Simonsen L, Spreeuwenberg P, Lustig R, Taylor RJ, Fleming DM, Kroneman M, et al. Global mortality estimates for the 2009 Influenza Pandemic from the GLaMOR project: A modeling study. PLoS Med. 2013;10:e1001558.
  3. Monto AS. Epidemiology of viral respiratory infections. Am J Med. 2002;112 Suppl 6A:4S–12S.
  4. Cromer D, van Hoek AJ, Jit M, Edmunds WJ, Fleming D, Miller E. The burden of influenza in England by age and clinical risk group: A statistical analysis to inform vaccine policy. J Infect. 2014;68:363–71.
  5. Simmerman JM, Uyeki TM. The burden of influenza in East and South-East Asia: A review of the English language literature. Influenza Other Respir Viruses. 2008;2:81–92.
  6. Pica N, Bouvier NM. Environmental factors affecting the transmission of respiratory viruses. Curr Opin Virol. 2012;2:90–5.
  7. Saha S, Chadha M, Shu Y; Group of Asian Researchers on Influenza (GARI). Divergent seasonal patterns of influenza types A and B across latitude gradient in Tropical Asia. Influenza Other Respir Viruses. 2016;10:176–84.
  8. Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases (NCIRD). Influenza (Flu). Georgia: Centers for Disease Control and Prevention, 2022.
  9. Sam JI. The burden of human influenza in Malaysia. Med J Malaysia. 2015;70:127–30.
  10. Department of Statistics Malaysia. Population of Malaysia. Putrajaya: Department of Statistics Malaysia, 2020.
  11. World Health Organization. World life expectancy. Geneva: World Health Organization, 2020.
  12. Lam TT, Tang JW, Lai FY, Zaraket H, Dbaibo G, Bialasiewicz S, et al. Comparative global epidemiology of influenza, respiratory syncytial and parainfluenza viruses, 2010-2015. J Infect. 2019;79:373–82.
  13. Sam IC, Su YC, Chan YF, Nor'E SS, Hassan A, Jafar FL, et al. Evolution of influenza B virus in Kuala Lumpur, Malaysia, between 1995 and 2008. J Virol. 2015;89:9689–92.
  14. Wong PL, Sii HL, P'ng CK, Ee SS, Yong Oong X, Ng KT, et al. The effects of age on clinical characteristics, hospitalization and mortality of patients with influenza-related illness at a tertiary care centre in Malaysia. Influenza Other Respir Viruses. 2020;14:286–93.
  15. Quidel. QuickVue Influenza A+B Test. San Diego: Quidel, 2022.
  16. Ang LW, Lim C, Lee VJ, Ma S, Tiong WW, Ooi PL, et al. Influenza-associated hospitalizations, Singapore, 2004-2008 and 2010-2012. Emerg Infect Dis. 2014;20:1652–60.
  17. Hernandez-Vargas EA, Wilk E, Canini L, Toapanta FR, Binder SC, Uvarovskii A, et al. Effects of aging on influenza virus infection dynamics. J Virol. 2014;88:4123–31.
  18. Rottoli M, Bernante P, Belvedere A, Balsamo F, Garelli S, Giannella M, et al. How important is obesity as a risk factor for respiratory failure, intensive care admission and death in hospitalised COVID-19 patients? Results from a single Italian centre. Eur J Endocrinol. 2020;183:389–97.
  19. Maccioni L, Weber S, Elgizouli M, Stoehlker AS, Geist I, Peter HH, et al. Obesity and risk of respiratory tract infections: results of an infection-diary based cohort study. BMC Public Health. 2018;18:271.
  20. Zhao X, Gang X, He G, Li Z, Lv Y, Han Q, et al. Obesity increases the severity and mortality of influenza and COVID-19: A systematic review and meta-analysis. Front Endocrinol (Lausanne). 2020;11:595109.
  21. Neidich SD, Green WD, Rebeles J, Karlsson EA, Schultz-Cherry S, Noah TL, et al. Increased risk of influenza among vaccinated adults who are obese. Int J Obes (Lond). 2017;41:1324–30.
  22. Rahman MM, Wong KK, Hanafiah A, Isahak I. Influenza and respiratory syncytial viral infections in Malaysia: Demographic and clinical perspective. Pak J Med Sci. 2014;30:161–5.
  23. Kopsaftis Z, Wood-Baker R, Poole P. Influenza vaccine for chronic obstructive pulmonary disease (COPD). Cochrane Database Syst Rev. 2018;6:CD002733.
  24. Mallia P, Johnston SL. Influenza infection and COPD. Int J Chron Obstruct Pulmon Dis. 2007;2:55–64.
  25. Godoy P, Castilla J, Soldevila N, Mayoral JM, Toledo D, Martín V, et al. Smoking may increase the risk of influenza hospitalization and reduce influenza vaccine effectiveness in the elderly. Eur J Public Health. 2018;28:150–5.
  26. Wong CM, Yang L, Chan KP, Chan WM, Song L, Lai HK, et al. Cigarette smoking as a risk factor for influenza-associated mortality: Evidence from an elderly cohort. Influenza Other Respir Viruses. 2013;7:531–9.
  27. Giurgea LT, Cervantes-Medina A, Walters KA, Scherler K, Han A, Czajkowski LM, et al. Sex differences in influenza: The challenge study experience. J Infect Dis. 2022;225:715–22.

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