Association Between Cigarette Smoking and Breast Milk Levels of Nesfatin-1, Irisin, and Oxidative Stress Markers

Authors

Nesibe Yildiz, Department of Medical Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul 34096, TurkeyFollow
Adnan Yilmaz, Department of Medical Biochemistry, Faculty of Medicine, Recep Tayyip ErdoganUniversity, Rize 53100, TurkeyFollow
Hatice Iskender, Department of Nutrition and Dietetics, Faculty of Healthy Sciences, Artvin Çoruh University, Artvin 08000, TurkeyFollow
Eda Dokumacioglu, Department of Nutrition and Dietetics, Faculty of Healthy Sciences, Artvin Çoruh University, Artvin 08000, TurkeyFollow

ORCID ID

Nesibe Yildiz : https://orcid.org/0000-0001-5728-5527

Adnan Yilmaz : https://orcid.org/0000-0003-4842-1173

Hatice Iskender : https://orcid.org/0000-0002-8063-4972

Eda Dokumacioglu : https://orcid.org/0000-0002-2223-1331

Abstract

Background: Breast milk is a very important functional food in the prevention of metabolic and chronic diseases. This study aimed to investigate the effects of smoking during pregnancy on the concentrations of nesfatin-1, irisin, and oxidative stress markers in breast milk.

Methods: This study included two groups of 14 smoking and 14 nonsmoking mothers. Malondialdehyde (MDA) level and superoxide dismutase (SOD) activity were measured according to the spectrophotometric method in breast milk samples. Nesfatin and irisin levels were measured by enzyme-linked immunosorbent assay.

Results: Levels of nesfatin-1 and MDA of the smoking group were significantly higher than those in the control group (p < 0.001). The SOD activity of the smoking group was significantly lower than that of the control group (p < 0.001). No significant difference was found in the breast milk irisin level between the study groups (p > 0.050).

Conclusions: Cigarette smoking increases MDA level and decreases SOD activity in breast milk. Nesfatin-1 levels would increase in accordance with increased oxidative stress, and nesfatin-1 acts as a protective mechanism to limit oxidative damage.

References

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Recommended Citation

Yildiz N, Yilmaz A, Iskender H, Dokumacioglu E. Association Between Cigarette Smoking and Breast Milk Levels of Nesfatin-1, Irisin, and Oxidative Stress Markers. Makara J Health Res. 2021;25.

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