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Abstract

Background: The presence of risk factors have a high risk of developing breast cancer. Our study aimed to find an association between sociodemographic factors and the risk of estrogen receptor (ER)-positive, progesterone receptor (PR)-positive breast cancer among women.

Methods: A cross-sectional study was conducted on 200 women with breast cancer. Association between sociodemographic factors and hormone receptor subtypes of breast cancer was found using the Chi-square test. Multiple logistic regression analysis was used to know the strong predictors of hormone receptor subtypes.

Results: The mean age was 50.08 (10.67) years. Comorbidities had a statistically significant association with ER-positive subtype (p = 0.007). Body mass index had a statistically significant association with PR-positive subtype (p = 0.042). Comorbidities was found to be the strong independent predictor for ER-positive (OR 2.28; 95% CI: 1.28–4.05, p = 0.003) and PR-positive subtypes (OR 1.78; 95% CI: 1.01–3.13, p = 0.03).

Conclusion: We conclude that in our study, body mass index was associated with PR-positive subtype, and comorbidities were associated with ER-positive subtype of breast cancer among the women. Comorbidities remained to be a strong independent predictor of ER-positive and PR-positive subtypes of breast cancer.

References

1. National Health Portal of India. Breast cancer awareness month. India: National Health Portal of India, 2019.

2. World Cancer Research Fund International/American Institute for Cancer Research. Continuous update project report: Diet, nutrition, physical activity and breast cancer. World Cancer Research Fund Network, 2017.

3. Brewer HR, Jones ME, Schoemaker MJ, Ashworth A, Swerdlow AJ. Family history and risk of breast cancer: An analysis accounting for family structure. Breast Cancer Res Treat. 2017;165:193–200.

4. Fortner RT, Sisti J, Chai B, Collins LC, Rosner B, Hankinson SE, et al. Parity, breastfeeding, and breast cancer risk by hormone receptor status and molecular phenotype: Results from the nurses’ health studies. Breast Cancer Res. 2019;21:40.

5. Kawai M, Malone KE, Tang MT, Li CI. Height, body mass index (BMI), BMI change, and the risk of estrogen receptor-positive, HER2-positive, and triple-negative breast cancer among women ages 20 to 44 years. Cancer. 2014;120:1548–56.

6. Sparano JA, Wang M, Zhao F, Stearns V, Martino S, Ligibel JA, et al. Obesity at diagnosis is associated with inferior outcomes in hormone receptor-positive operable breast cancer. Cancer. 2012;118:5937–46.

7. Bronsveld HK, Jensen V, Vahl P, De Bruin ML, Cornelissen S, Sanders J, et al. Diabetes and breast cancer subtypes. PLoS One. 2017;12:e0170084.

8. Liao S, Li J, Wang L, Zhang Y, Wang C, Hu M, et al. Type 2 diabetes mellitus and characteristics of breast cancer in China. Asian Pac J Cancer Prev. 2010;11:933–7.

9. Chen H, Cook LS, Tang MC, Hill DA, Wiggins CL, Li CI. Relationship between diabetes and diabetes medications and risk of different molecular subtypes of breast cancer. Cancer Epidemiol Biomarkers Prev. 2019;28:1802–8.

10. Phipps AI, Ichikawa L, Bowles EJ, Carney PA, Kerlikowske K, Miglioretti DL, et al. Defining menopausal status in epidemiologic studies: A comparison of multiple approaches and their effects on breast cancer rates. Maturitas. 2010;67:60–6.

11. Aziz N, Kallur SD, Nirmalan PK. Implications of the revised consensus body mass indices for Asian Indians on clinical obstetric practice. J Clin Diagn Res. 2014;8:OC01–3.

12. Reis HF, Ladeia AM, Passos EC, Santos FG, Wasconcellos LT, Correia LC, et al. Prevalence and variables associated with physical inactivity in individuals with high and low socioeconomic status. Arq Bras Cardiol. 2009;92:193–8.

13. Rao M, Joshee R, Deval M, Sethi N. Clinico-morphological profile in breast cancer patients in a tertiary care hospital in western Rajasthan. J Evol Med Dent Sci. 2016;5:262–5.

14. Mench K, Phira T. A clinic-demographic study of patients with carcinoma of breast at tertiary health care centre. Medpulse-Int Med J. 2016; 3:884–8.

15. Shoed MFR, Pinate AR, Shingade PP. Risk factors and clinical presentations of breast cancer patients: A hospital-based study. Int Surg J. 2017;4:645–9.

16. Negi M, Kumar S, Devi S, Raina SK. Profiling estrogen receptor, progesterone receptor, and human epidermal growth factor receptor2/neu in breast carcinoma: Study of 111 consecutive cases. J Sci Soc. 2018;45:13–6.

17. Olatunji T, Sowunmi AC, Ketiku KK, Campbell OB. Sociodemographic correlates and management of breast cancer in Radiotherapy Department, Lagos University Teaching Hospital: A 10-year review. J Clin Sci. 2019;16:111–9.

18. Patnayak R, Jena A, Rukmangadha N, Chowhan AK, Sambasivaiah K, Phaneendra BV, et al. Hormone receptor status (estrogen receptor, progesterone receptor), human epidermal growth factor-2 and p53 in South Indian breast cancer patients: A tertiary care center experience. Indian J Med Paediatr Oncol. 2015;36:117–22.

19. Mahmood H, Faheem M, Mahmood S, Sadiq M, Irfan J. Impact of age, tumor size, lymph node metastasis, stage, receptor status and menopausal status on overall survival of breast cancer patients in Pakistan. Asian Pac J Cancer Prev. 2015;16:1019–24.

20. Shim HJ, Kim SH, Kang BJ, Choi BG, Kim HS, Cha ES, et al. Breast cancer recurrence according to molecular subtype. Asian Pac J Cancer Prev. 2014;15:5539–44.

21. Collaborative Group on Hormonal Factors in Breast Cancer. Breast cancer and breastfeeding: Collaborative reanalysis of individual data from 47 epidemiological studies in 30 countries, including 50302 women with breast cancer and 96973 women without the disease. Lancet. 2002;360:187–95.

22. Gajalakshmi V, Mathew A, Brennan P, Rajan B, Kanimozhi VC, Mathews A, et al. Breastfeeding and breast cancer risk in India: A multicenter case-control study. Int J Cancer. 2009;125:662–5.

23. McTiernan A. Mechanisms linking physical activity with cancer. Nat Rev Cancer. 2008; 8:205–11.

24. Friedenreich CM, Neilson HK, Lynch BM. State of the epidemiological evidence on physical activity and cancer prevention. Eur J Cancer. 2010;46:2593–604.

25. The Premenopausal Breast Cancer Collaborative Group. Association of body mass index and age with subsequent breast cancer risk in premenopausal women. JAMA Oncol. 2018;4:e181771.

26. Brown KA. Impact of obesity on mammary gland inflammation and local estrogen production. J Mammary Gland Biol Neoplasia. 2014;19:183–9.

27. Gillespie EF, Sorbero ME, Hanauer DA, Sabel MS, Herrmann EJ, Weiser LJ, et al. Obesity and angiolymphatic invasion in primary breast cancer. Ann Surg Oncol. 2010;17:752–9.

28. Land LH, Dalton SO, Jorgensen TL, Ewertz M. Comorbidity and survival after early breast cancer: A Review. Crit Rev Oncol Hematol. 2012;81:196–205.

29. Land LH, Dalton SO, Jensen MB, Ewertz M. Influence of comorbidity on the effect of adjuvant treatment and age in patients with early stage breast cancer. Br J Cancer. 2012;107:1901–7.

30. Kimmick G, Fleming ST, Sabatino SA, Wu XC, Hwang W, Wilson JF, et al. Comorbidity burden and guideline-concordant care for breast cancer. J Am Geriatr Soc. 2014;62:482–8.

31. Sabatino SA, Thompson TD, Wu XC, Fleming ST, Kimmick GG, Trentham-Dietz A, et al. The influence of diabetes severity on receipt of guideline-concordant treatment for breast cancer. Breast Cancer Res Treat. 2014;146:199–209.

32. Chia VM, Page JH, Rodriguez R, Yang SJ, Huynh J, Chao C. Chronic comorbid conditions associated with risk of febrile neutropenia in breast cancer patients treated with chemotherapy. Breast Cancer Res Treat. 2013;138:621–31.

33. Chao C, Page JH, Yang SJ, Rodriguez R, Huynh J, Chia VM. History of chronic comorbidity and risk of chemotherapy induced febrile neutropenia in cancer patients not receiving G-CSF prophylaxis. Ann Oncol. 2014;25:1821–9.

34. Smith AW, Reeve BB, Bellizzi KM, Harlan LC, Klabunde CN, Amsellem M, et al. Cancer, comorbidities, and health-related quality of life of older adults. Health Care Financ Rev. 2008;29:41–56.

35. Heyler LK, Varnic M, Le LW, Leong W, McCready D. Obesity is a risk factor for developing postoperative lymphedema in breast cancer patients. Breast J. 2010;16:48–54.

36. Schmitz KH, Neuhouser ML, Agurs-Collins T, Zanetti KA, Cadmus-Bertram L, Dean LT, et al. Impact of obesity on cancer survivorship and the potential relevance of race and ethnicity. J Natl Cancer Inst. 2013;105:1344–54.

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