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Majalah Ilmu Kefarmasian

Abstract

The influence of Avicel PH 102 as disintegrant on physical characteristic and dissolution rate of piroxicam Orally Disintegrating Tablet prepared by direct compression method was observed in this research. Concentration of Avicel PH 102 used were 5%, 10%, 15% and 0% as a control. Physical characteristics of the powder blend including flow rate and angle of repose showed good attributes. The powder blend was pressed into tablet by hydraulic press with a pressure of 1 ton and diameter of 8 mm. The physical characteristic of piroxicam orally disintegrating tablet including hardness, friability, disintegration time, and dissolution rate were examined. The hardness of all formulas were between 0,99 – 2,78 kP, friability were between 3,45% – 1,25%, disintegration time were between 223,67– 18,33 sec and drug released at 45 minutes were between 32,71%– 88,63%. The results showed that increasing the concentration of Avicel PH 102 would increase the hardness, and dissolution rate and decrease the friability and disintegration time of piroxicam orally disintegrating tablet . From statistical analysis (µ = 0,05), it could be seen that there was significant difference in physical characteristics and dissolution rate of all formulas. Among all formulas, it could be concluded that formula with 10% concentration of Avicel PH 102 was the optimum formula

Bahasa Abstract

Telah dilakukan penelitian tentang pengaruh Avicel PH 102 terhadap karakteristik fisik dan laju disolusi Orally Disintegrating Tablet piroksikam dengan metode cetak langsung. Konsentrasi Avicel PH 102 yang digunakan 5%, 10%, 15% dan 0% sebagai kontrol. Karakteristik fisik campuran serbuk yang meliputi kecepatan alir dan sudut diam memberikan hasil yang memenuhi persyaratan. Campuran serbuk kemudian di cetak menjadi tablet dengan alat penekan hidrolik dengan tekanan 1 ton selama 3 detik pada punch berdiameter 8 mm. Kemudian Orally Disintegrating Tablet piroksikam diperiksa karakteristik fisik yang meliputi kekerasan, kerapuhan, waktu disintegrasi dan laju disolusinya. Kekerasan tablet dari semua formula berkisar antara 0,99 – 2,78 kP, kerapuhan 3,45% – 1,25%, waktu disintegrasi 223,67– 18,33 detik dan laju disolusi pada 45 menit adalah 32,71%– 88,63%. Hasil pemeriksaan ini menunjukkan bahwa peningkatan konsentrasi Avicel PH 102 akan meningkatkan kekerasan dan laju disolusi serta menurunkan kerapuhan dan waktu disintegrasinya. Analisis statistik (µ = 0,05) menunjukkan bahwa ada perbedaan bermakna mutu fisik dan laju disolusi antar semua formula Orally Disintegrating Tablet piroksikam. Dari penelitian ini dapat disimpulkan bahwa formula dengan konsentrasi Avicel PH 102 10% merupakan formula yang paling optimal. Kata Kunci : Avicel PH 102, cetak langsung, disintegrasi oral tablet piroksikam, karakteristik fisik, kecepatan disolusi.

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