"Intermittent Fasting and Cardiometabolic Health" by Tri Siswati, Lathifa Zahra Putri Nugroho et al.
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Abstract

Obesity is a significant global health challenge, with adverse impacts on cardiometabolic health such as hypertension, dyslipidemia, and insulin resistance. One promising intervention in obesity management is intermittent fasting (PI). However, scientific evidence on the impact of IF on cardiometabolic health is still limited. This study used a scoping review design to evaluate the association between IF and cardiometabolic health in obese adults. Reference sources are available in English at least abstract between 2015–2023 as well as from PubMed and Google Scholar web sources. The search keywords on PubMed are "Adult AND intermittent fasting AND cardiometabolic" and on Google Scholar is "Intermittent fasting and cardiovascular relationships". A total of 6 articles were analyzed in this context presented in the form of tables including countries and authors, study design, participant characteristics, IF assessment on cardiometabolic states and their results. The study showed that IF methods such as Alternate Day Fasting (ADF), Time-Restricted Feeding (TRF), and the 5:2 method had different effects on cardiometabolic health. ADF is superior in weight loss, while TRF is more effective at lowering triglyceride levels. The 5:2 method showed a significant reduction in waist circumference and oxidative stress. The mechanism of IF benefits involves modulation of the gut microbiota and reduction of systemic inflammation. These results demonstrate the potential of IF as a non-pharmacological approach to manage obesity and its cardiometabolic complications. However, studies with large-scale trial designs and longer intervention durations are needed to develop standard guidelines and ensure the sustainability of IF benefits.

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Bahasa Abstract

Obesitas merupakan tantangan kesehatan global yang signifikan, dengan dampak buruk terhadap kesehatan kardiometabolik seperti hipertensi, dislipidemia, dan resistensi insulin. Salah satu intervensi yang menjanjikan dalam manajemen obesitas adalah puasa intermiten (PI). Namun, bukti ilmiah tentang dampak IF terhadap kesehatan kardiometabolik masih terbatas. Penelitian ini menggunakan desain scoping review untuk mengevaluasi hubungan antara IF dan kesehatan kardiometabolik pada orang dewasa obesitas. Sumber referensi adalah tersedia dalam bahsa Inggris minimal abstrak antara tahun 2015–2023 serta dari sumber web PubMed dan Google Scholar. Kata kunci pencarian di PubMed adalah “Dewasa DAN Puasa Intermiten DAN Kardiometabolik” dan di Google Scholar adalah “Hubungan intermitent fasting dan kardiovaskular”. Sebanyak 6 artikel dianalisis dalam artike ini disajikan dalam bentuk table meliputi negara dan penulis, desain study, karakteristik partisipan, asesment IF pada keadaan kardiometabolik dan hasilnya. Hasil penelitian ini menunjukkan bahwa metode IF seperti Alternate Day Fasting (ADF), Time-Restricted Feeding (TRF), dan metode 5:2 memiliki efek berbeda pada kesehatan kardiometabolik. ADF lebih unggul dalam menurunkan berat badan, sedangkan TRF lebih efektif menurunkan kadar trigliserida. Metode 5:2 menunjukkan pengurangan signifikan pada lingkar pinggang dan stres oksidatif. Mekanisme manfaat IF melibatkan modulasi mikrobiota usus dan pengurangan peradangan sistemik. Sebagai kesimpulan, IF mempunyai potensi sebagai pendekatan non-farmakologis untuk mengelola obesitas dan komplikasi kardiometaboliknya. Namun, penelitian dengan desain uji coba berskala besar dan durasi intervensi yang lebih panjang diperlukan untuk mengembangkan pedoman standar dan memastikan keberlanjutan manfaat IF.

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