Relationship Between Plasma Fluoride Levels, Glutathione Peroxidase Activity, Hemoglobin, and Abortion in Rural and Urban Pregnant Women from Settat (Morocco)

Authors

Lalla Asmaa Katir Masnaoui, Natural Resources and Environment, Neurosciences, Laboratory of Biochemistry, Faculty of Sciences and Techniques, Hassan First University of Settat, Settat 26000, MoroccoFollow
Abdellatif Rahim, Natural Resources and Environment, Neurosciences, Laboratory of Biochemistry, Faculty of Sciences and Techniques, Hassan First University of Settat, Settat 26000, MoroccoFollow
Habiba Bouchab, Natural Resources and Environment, Neurosciences, Laboratory of Biochemistry, Faculty of Sciences and Techniques, Hassan First University of Settat, Settat 26000, MoroccoFollow
Bouchra El Amiri, National Institute for Agriculture Animal Production Unit, Regional Center Agricultural Research of Settat, National Institute for Agricultural Research, Avenue Ennasr, Rabat 10090, MoroccoFollow
Boubker Nasser, Natural Resources and Environment, Neurosciences, Laboratory of Biochemistry, Faculty of Sciences and Techniques, Hassan First University of Settat, Settat 26000, MoroccoFollow
Essamadi Abdel Khalid, Natural Resources and Environment, Neurosciences, Laboratory of Biochemistry, Faculty of Sciences and Techniques, Hassan First University of Settat, Settat 26000, MoroccoFollow

ORCID ID

Lalla Asmaa Katir Masnaoui: 0000-0001-5866-1539

Abdellatif Rahim: 0000-0001-5832-1710

Habiba Bouchab: 0000-0002-2632-7840

Bouchra El Amiri: 0000-0003-3443-5988

Boubker Nasser: 0000-0002-5795-365X

Abdel Khalid Essamadi Natural: 0000-0003-4537-1684

Abstract

Background: This study aimed to investigate the relationship between plasma fluoride and hemoglobin levels, glutathione peroxidase (GPx) activity, and abortion among rural and urban pregnant women from Settat province (Morocco).

Methods: Blood samples were collected from rural pregnant women who had not undergone abortion (N = 224), rural pregnant women who had an abortion (N = 38), urban pregnant women who had not undergone abortion (N = 163), and urban pregnant women who had an abortion (N = 14).

Results: The highest (p < 0.01) plasma fluoride levels and the lowest (p < 0.01) GPx activity were observed in rural pregnant women. In all participants, plasma fluoride levels were significantly higher (p < 0.001), and the GPx activity was significantly (p < 0.001) lower in pregnant women who had an abortion compared with those who did not undergo such process. No significant difference was observed between the hemoglobin levels of all participants. Furthermore, abortion was positively correlated with plasma fluoride levels (p < 0.001) and negatively correlated with GPx activity (p < 0.001) in rural participants.

Conclusions: Rural pregnant women had higher plasma fluoride levels and lower GPx activity, which correlated with the increased abortion risk and oxidative stress.

References

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Recommended Citation

Katir Masnaoui L, Rahim A, Bouchab H, El Amiri B, Nasser B, Abdel Khalid E, et al. Relationship Between Plasma Fluoride Levels, Glutathione Peroxidase Activity, Hemoglobin, and Abortion in Rural and Urban Pregnant Women from Settat (Morocco). Makara J Health Res. 2023;27.

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