Abstract
Diabetes Mellitus (DM) patients are at risk to have the diabetic ulcer. The main reason for DM’s patient with ulcer complication to be treated and healed in hospital is bacterial infection. One of many bacteria that infects diabetic ulcer is Pseudomonas aeruginosa. The effort to treat this infection is by using antibiotic. The use of antibiotic unfortunately, is often found inaccurate causing the microbe resistance to occur. To choose the right antibiotic, it needs to test the antibiotic’s sensitivity towards Pseudomonas aeruginosa. The aim of this study is to determine the sensitivity of antibiotics against Pseudomonas aeruginosa. Sample used was taken from diabetic ulcers swab with grade III and IV Wagner. The identification of bacteria was managed using the biochemical test and Gram staining test. Antibiotic sensitivity was determined by Kirby Bauer method. Antibiotics that were found still sensitive towards Pseudomonas aeruginosa included ciprofloxacin, norfloxacin, imipenem, levofloxacin, meropenem, ceftriaxone, and cefotaxime, whereas cefadroxil and amikacin were resistant. Antibiotics that can be used for Pseudomonas aeruginosa in diabetic foot ulcer patients are ciprofloxacin, norfloxacin, imipenem, levofloxacin, meropenem, ceftriaxone, and cefotaxime.
References
Aulia F, N. (2008) Pola Kuman Aerob dan Sensitifitas Gangren Diabetik. Thesis. Medan: Repository FK USU; 2008.
Frykberg R.G, Zgonis T, Armstrong D.G, Driver V.R, Giurini J.M, Kravitz R.M, et al. (2006) Diabetic Foot Disorders A Clinical Practice Guideline. The Journal of Foot an Ankle; 45(5): 1-49.
Manisha J, Mitesh PH, Nidhi SK, Modi DJ, Vegad MM. (2012) Spectrum of Microbial Flora in Diabetic Foot Ulcer And Antibiotic Sensitivity Pattern in Tertiary Care Hospital in Ahmedabad, Gujarat : National Journal of Medical. Research. Vol 3: 354-57.
Meletis G, Bagkeri M. (2013) Pseudomonas aeruginosa:Multi-Drug-Resistance Development and Treatment Options. Greece: Licensee Intech.
Mayasari E. (2006) Pseudomonas aeruginosa: Karakteristik, Infeksi dan Penanganan. Medan: USU Repository.
PERKENI. (2011). Konsensus Pengelolaan dan Pencegahan Diabetes Mellitus Tipe 2 di Indonesia. Jakarta : FKUI RSCM.
Sari R, Apridamayanti P. (2015) Identifikasi Bakteri Penghasil ESBL pada Penderita Ulkus Diabetikum Derajat III dan IV Wagner. Pontianak : Laporan Penelitian DIPA Universitas Tanjungpura.
Setiabudy R. Farmakologi dan Terapi. (2011) Jakarta: Department of Pharmacology and Therapeutic of Medical Faculty Universitas Indonesia.
Sulistiyaningsih. (2010) Uji Kepekaan Beberapa Sediaan Antiseptik Terhadap Bakteri Pseudomonas aeruginosa Dan Pseudomonas aeruginosa Multi Resisten (PAMR). Jatinangor: Independent Research Report.
Tambunan M. Perawatan Kaki Diabetes. (2007) Dalam: Soegondo S, dkk : Penatalaksanaan Diabetes Melitus Terpadu. Jakarta: Balai Penerbit FKUI.
Wid S, Roglic G, Green A, Sicree R, King H. (2004) Global Prevalence of Diabetes. Edinburgh: Diabetes Care; 27(5): 1050-1051.
Recommended Citation
Apridamayanti, Pratiwi; Meilinasary, Khairunnisa Azani; and Sari, Rafika
(2016)
"Antibiotic Sensitivity in Pseudomonas aeruginosa of DiabeticPatient’s Foot Ulcer,"
Pharmaceutical Sciences and Research: Vol. 3:
No.
2, Article 3.
DOI: 10.7454/psr.v3i2.3289
Available at:
https://scholarhub.ui.ac.id/psr/vol3/iss2/3
Included in
Natural Products Chemistry and Pharmacognosy Commons, Other Pharmacy and Pharmaceutical Sciences Commons, Pharmaceutics and Drug Design Commons