Abstract
Indonesia especially Kalimantan Barat well known by its biodiversity, one of the potential resource is Kesum leaves. Kesum leaves are potential by its antibacterial effect, so that it can be formulated into pharmaceutical dosage form, especially gel. This research aims to know the best comparison between Carbopol 940 and Hydroxypropyl methylcellulose (HPMC) gel base affecting the physical stability of methanol extract and fraction of kesum leaves gel by Simplex Lattice Design (SLD) method. Gels were prepared into three variation base such as gel A (100% Carbopol - 0% HPMC); gel B (0% Carbopol - 100% HPMC); and gel C (50% Carbopol – 50% HPMC). According to SLD method, the optimum combination obtained among the basis were 100% Carbopol - 0% HPMC for Kesum leaves methanol extract gel and 10% Carbopol – 90% HPMC for Kesum leaves methanol fraction gel. Then , the gels were tested their physical stability including adhesive ability spreadability and pH. Results were analyzed using One sample t- test and was known there was no difference of the physical stability between Kesum leaves methanol extract gel and Kesum leaves methanol fraction gel.
Bahasa Abstract
Indonesia terutama Kalimantan Barat terkenal akan kekayaan hayatinya, salah satu nya adalah daun kesum. Daun kesum berpotensi sebagai antibakteri sehingga tepat untuk diformulasi dalam bentuk sediaan obat terutama gel. Penelitian ini bertujuan untuk mengetahui perbandingan yang tepat antara basis gel karbopol 940 dan Hidroksipropil metilselulosa (HPMC) terhadap stabilitas sifat fisik gel ekstrak dan fraksi metanol daun kesum dengan metode Simplex Lattice Design (SLD). Gel dibuat dalam tiga variasi basis yaitu gel A (100% karbopol - 0% HPMC); gel B (0% karbopol - 100% HPMC); dan gel C (50% karbopol – 50% HPMC). Berdasarkan perhitungan dengan metode SLD didapatkan komposisi optimum basis gel yaitu 100% karbopol - 0% HPMC untuk gel ekstrak metanol daun kesum dan 10% karbopol – 90% HPMC untuk gel fraksi metanol daun kesum. Gel kemudian diuji sifat fisik nya meliputi pengujian daya lekat, daya sebar dan pH. Hasil pengujian dianalisis menggunakan One Sample t- test dan diketahui tidak ada perbedaan bermakna antara sifat fisik gel ektrak dan fraksi metanol daun kesum.
References
Bolton, S. (1997). Pharmaceutical Statistic Practical and Clinical Application, Third Edition, Marcel Dekker inc. New York, page 611- 619.
Ida, N. Dan Fauziah, N. (2012). Uji Stabilitas Fisik Gel Ekstrak Lidah Buaya (Aloe vera L.). Majalah Farmasi dan Farmakologi, 16(2), 79- 84.
Liebermen, H.A. (1996). Pharmaceutical Dosage Form, Vol. 2, Marcel Dekker Inc, New York, 400
Martin, A., Swabrick, J., Cammarata, A. (1993). Farmasi Fisik. UI Press. Jakarta. Halaman 1171,1172-1175.
Rowe, R.C., Sheskey, P.J., Quinn, M. (2009). Handbook of Pharmaceutical Excipients. Fifth Edition. Pharmaceutical Press and American Pharmacist Association : Washington DC. Halaman 111, 301, 794.
Sari, R. dan Isadiartuti, D. (2006). Studi Efektivitas Sediaan Gel Antiseptik Tangan Ekstrak Daun Sirih (Piper betle Linn). Indonesian J. Pharm, 17(4), 163-169.
Wibowo, M.A. (2007). Uji antimikroba fraksi metanol dan dietil eter daun tanaman kesum. Agripura, 3(2), 410-414.
Wibowo, M.A., Anwari, M.S., Aulanni’am, dan Rahman, F. (2009). Skrining Fitokimia Fraksi Metanol, Dietil- eter dan n- Heksana Ekstrak Daun Kesum (Polygonum minus Huds.). Agripura,16(4), 56-58.
Yaacob KB. (1987). Kesom oil: A natural source of aliphatic aldehydes. Perfumer and Flavorist,12, 27-30.
Recommended Citation
Sari, Rafika; Nurbaeti, Siti Nani; and Pratiwi, Liza
(2016)
"Optimasi Kombinasi Karbopol 940 dan HPMC Terhadap Sifat Fisik Gel Ekstrak dan Fraksi Metanol Daun Kesum (Polygonum minus Huds.) dengan metode Simplex Lattice Design,"
Pharmaceutical Sciences and Research: Vol. 3:
No.
2, Article 2.
DOI: 10.7454/psr.v3i2.3288
Available at:
https://scholarhub.ui.ac.id/psr/vol3/iss2/2
Included in
Natural Products Chemistry and Pharmacognosy Commons, Other Pharmacy and Pharmaceutical Sciences Commons, Pharmaceutics and Drug Design Commons
