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Abstract

Hylocereus polyrhizus Britton and Rose (Red dragon fruit) has been shown to have antioxidant activity which contains vitamin C, polyphenol, and flavonoid. This research was aimed to investigate antioxidant activity from H. polyrhizus in form of lotion. Lotion were made with 5 concentration from H. polyrhizus methanol extract were 0.04, 0.08, 0.16, 0.32 and 0.64%. Lotion antioxidant activity was measured using DPPH method. The result showed that H. polyrhizus methanol extract had antioxidant activity with inhibition concentration were 19.99±0.33; 25.01±0.08; 39.14±0.04; 66.69±0.12 and 83.37±0.05. The result showed significant differences on antioxidant activity. The physical stability observation of five formula with cycling test method showed unstability because of discolouration (oxidation). As well as the methods of mechanical test showed unstability of lotion because saponification process.

Bahasa Abstract

Hylocereus polyrhizus (Buah naga merah) telah terbukti memiliki aktivitas antioksidan dengan kandungan seperti vitamin C, polifenol, dan flavonoid. Penelitian ini bertujuan untuk menguji aktivitas antioksidan dari H. polyrhizus dalam bentuk sediaan losio. Formulasi losio dibuat dengan 5 seri konsentrasi dari ekstrak metanol H. polyrhizus berturut-turut yaitu 0,04; 0,08; 0,16; 0,32 dan 0,64%. Efektivitas antioksidan losio diuji dengan metode DPPH. Hasil penelitian menunjukkan bahwa ekstrak metanol H. polyrhizus memiliki efektivitas antioksidan dengan persen daya hambat masing-masing sebesar 19,99±0,33; 25,01±0,08; 39,14±0,04; 66,69±0,12 dan 83,37±0,05. Analisis data memberikan hasil berbeda signifikan pada uji efektivitas antioksidan. Pengamatan stabilitas dengan metode cycling test menunjukkan ketidakstabilan oleh karena perubahan warna (oksidasi) di setiap formula pada siklus kedua. Begitu pula dengan metode uji mekanik menunjukan ketidakstabilan losio karena proses penyabunan.

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