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Abstract

Herbal medicine has become popular worldwide, especially in developing countries, with around 80% of the population opting for herbal treatments. The perceived benefits of natural remedies, such as affordability and fewer side effects, drive this trend. Herbal therapies effectively manage skin diseases, infections, and common ailments. However, the absorption of bioactive compounds in herbal extracts is often limited. Recent developments in nano-based herbal delivery systems, like nanosomal, show promise in enhancing the efficacy of herbal remedies for topical applications, providing improved solubility, stability, and skin penetration. This review describes various nanosomal studies developed and successfully used to enhance the topical delivery of natural compounds, including liposomes, ethosomes, transfersomes, transethosomes, phytosomes, and niosomes.

References

Alharbi, W. S., Almughem, F. A., Almehmady, A. M., Jarallah, S. J., Alsharif, W. K., Alzahrani, N. M., & Alshehri, A. A. (2021). Phytosomes as an emerging nanotechnology platform for the topical delivery of bioactive phytochemicals. Pharmaceutics, 13(9). https://doi.org/10.3390/pharmaceutics13091475

Ajazuddin, & Saraf, S. (2010). Applications of novel drug delivery system for herbal formulations. Fitoterapia, 81(7), 680-689. https://doi.org/10.1016/j.fitote.2010.05.001

Anwar, E., Ramadon, D., & Ardi, G. D. (2018). Novel transethosome containing green tea (Camellia sinensis L. Kuntze) leaf extract for enhanced skin delivery of epigallocatechin gallate: Formulation and in vitro penetration test. International Journal of Applied Pharmaceutics, 10(Special Issue 1), 299-302. https://doi.org/10.22159/ijap.2018.v10s1.66

Arsude, R. S., Sakhare, R. S., & Kshirsagar, S. J. (2023). A comprehensive review on application of novel drug delivery system in phytomedicine. Journal of Pharmaceutical Research International, 35(20), 1–11.

Bodnár, K., Fehér, P., Ujhelyi, Z., Bácskay, I., & Józsa, L. (2024). Recent approaches for the topical treatment of psoriasis using nanoparticles. Pharmaceutics, 16(4). https://doi.org/10.3390/pharmaceutics16040449

Carita, A. C., Eloy, J. O., Chorilli, M., Lee, R. J., & Leonardi, G. R. (2018). Recent advances and perspectives in liposomes for cutaneous drug delivery. Current Medicinal Chemistry, 25(5), 606–635. https://doi.org/10.2174/0929867324666171009120154

Castangia, I., Manca, M. L., Allaw, M., Hellström, J., Granato, D., & Manconi, M. (2021). Jabuticaba (Myrciaria Jaboticaba) peel as a sustainable source of anthocyanins and ellagitannins delivered by phospholipid vesicles for alleviating oxidative stress in human keratinocytes. Molecules, 26(21). https://doi.org/10.3390/molecules26216697

Chauhan, S., Gulati, N., & Nagaich, U. (2019). Fabrication and evaluation of ultra-deformable vesicles for atopic dermatitis as topical delivery. International Journal of Polymeric Materials and Polymeric Biomaterials, 68(5), 266-277. https://doi.org/10.1080/00914037.2018.1443932

Chen, S., Hanning, S., Falconer, J., Locke, M., & Wen, J. (2019). Recent advances in non-ionic surfactant vesicles (niosomes): Fabrication, characterization, pharmaceutical, and cosmetic applications. European Journal of Pharmaceutics and Biopharmaceutics, 144, 18-39. https://doi.org/10.1016/j.ejpb.2019.08.015

Choudhary, N., & Sekhon, B.S. (2011). An overview of advances in the standardization of herbal drugs. Corpus ID: 55924669

Dangles, O., & Dufour, C. (2006). Flavonoid–ligand interactions: Binding of (−)-epicatechin to human serum albumin. Journal of Agricultural and Food Chemistry, 54(6), 2451–2459. https://doi.org/10.1021/jf053072f

Danish, I. (2024). Phytosome: Recent investigation for a new drug delivery system. International Journal of Newgen Research in Pharmacy & Healthcare. https://doi.org/10.61554/ijnrph.v2i1.2024.61.

Dave, V., Kumar, D., Lewis, S., & Paliwal, S. (2010). Ethosome for enhanced transdermal drug delivery of aceclofenac. International Journal of Drug Delivery, 2(1), 81-92. https://doi.org/10.5138/ ijdd.2010.0975.0215.02016

DiPiro, J. T., Yee, G. C., Posey, L. M., Haines, S. T., Nolin, T. D., & Ellingrod, V. L. (2020). Pharmacotherapy: A pathophysiologic approach (11th ed.). New York, NY: McGraw-Hill Education.

DJPEN. (2014). Indonesian herbal medicine (Directorate General of PEN/MJL/005/9/2014). Directorate General of National Export Development of the Ministry of Trade.

Duangjit, S., Sila-On, W., Puapempoonsiri, U., Jitseang, K., Ngawhirunpat, T., & Bumrungthai, S. (2017). Development of curcumin-loaded nanovesicles for antiaging cosmetics: Liposomes, transfersomes, ethosomes, and niosomes. Thai Journal of Pharmaceutical Sciences (TJPS), 41(5th IPNaCS Conference Issue).

El-Gizawy, S., El-Maghraby, G., & Hedaya, A. (2019). Formulation of acyclovir-loaded solid lipid nanoparticles: design, optimization, and in vitro characterization. Pharmaceutical Development and Technology, 24, 1287-1298. https://doi.org/10.1080/10837450.2019.1667385

Fitrya, F., Fithri, N. A., Amriani, A., Haryati, A., & Wijaya, D. P. (2021). Preparation and characterization of petai pods extract (Parkia speciosa Hassk.) loaded ethosomes. Science and Technology Indonesia, 6(1), 19-24. https://doi.org/10.26554/sti.2021.6.1.19-24

Gruber, P., & Zito, P. M. (2023). Skin Cancer. In StatPearls [Internet]. StatPearls Publishing. Available from https://www.ncbi.nlm.nih.gov/books/NBK441949/ [Accessed 08 August 2024].

Hassan, A. S., Hofni, A., Abourehab, M. A. S., & Abdel-Rahman, I. A. M. (2023). Ginger extract-loaded transethosomes for effective transdermal permeation and anti-inflammation in a rat model. International Journal of Nanomedicine, 18, 1259-1280. https://doi.org/10.2147/IJN.S400604

Iskandar, B., Liu, T.-W., Mei, H.-C., Kuo, I.-C., Surboyo, M. D. C., Lin, H.-M., & Lee, C.-K. (2024). Herbal nanoemulsions in cosmetic science: A comprehensive review of design, preparation, formulation, and characterization. Journal of Food and Drug Analysis, 32(4), Article 4. https://doi.org/10.38212/2224-6614.3526

Iswandana, R., Sutriyo, S., Gunawan, M., Larasati, S. A., & Putri, F. A. (2021). Colon-targeted protein delivery by using solid lipid nanoparticles. Journal of Applied Pharmaceutical Science, 11(9), 118-123. https://doi. org/10.7324/JAPS.2021.110914

Jalili, A., Bagherifar, R., Nokhodchi, A., Conway, B., & Javadzadeh, Y. (2023). Current advances in nanotechnology-mediated delivery of herbal and plant-derived medicines. Advanced Pharmaceutical Bulletin, 13, 712 - 722. https://doi.org/10.34172/apb.2023.087.

Jamaludin, R., Mohd Daud, N., Raja Sulong, R. S., Yaakob, H., Abdul Aziz, A., Khamis, S., & Md Salleh, L. (2021). Andrographis paniculata-loaded niosome for wound healing application: Characterization and in vivo analyses. Journal of Drug Delivery Science and Technology, 63. https://doi.org/10.1016/j.jddst.2021.102427

Jufri, M., Iswandana, R., Wardani, D. A., & Malik, S. F. (2022). Formulation of red fruit oil nanoemulsion using sucrose palmitate. International Journal of Applied Pharmaceutics, 14(5), 175-180. https://doi.org/10.22159/ijap.2022v14i5.44314

Kapoor, B., Gupta, R., Gulati, M., Singh, S. K., Khursheed, R., & Gupta, M. (2019). The why, where, who, how, and what of vesicular delivery systems. Advances in Colloid and Interface Science, 271. https://doi.org/10.1016/j.cis.2019.07.006

Katara, R., & Majumdar, D. (2013). Eudragit RL 100-based nanoparticulate system of aceclofenac for ocular delivery. Colloids and surfaces. B, Biointerfaces, 103, 455-62. https://doi.org/10.1016/j. colsurfb.2012.10.056.

Kazmi, I., Al-Abbasi, F. A., Nadeem, M. S., Altayb, H. N., Alshehri, S., & Imam, S. S. (2021). Formulation, optimization, and evaluation of a luteolin-loaded topical nanoparticulate delivery system for skin cancer. Pharmaceutics, 13(11). https://doi.org/10.3390/pharmaceutics13111749

Kesarwani, K., & Gupta, R. (2013). Bioavailability enhancers of herbal origin: An overview. Asian Pacific Journal of Tropical Biomedicine, 3(4), 253-266. https://doi.org/10.1016/S2221-1691(13)60060-X

Khattab, W., El-Dein, E., & El-Gizawy, S. (2020). Full factorial design and optimization of olmesartan medoxomil–loaded oily-core polymeric nanocapsules with improved in vitro stability. Journal of Pharmaceutical Innovation, 16, 673 - 687. https://doi.org/10.1007/s12247-020-09479-5.

Khogta, S., Patel, J., Barve, K., & Londhe, V. (2020). Herbal nano-formulations for topical delivery. Journal of Herbal Medicine, 20. https://doi.org/10.1016/j.hermed.2019.100300

Kim, J. K., Kwon, Y. E., Lee, S. G., Jeong, J. M., Kim, J. G., & Kim, Y. J. (2018). Comparative SEM and TEM analyses of apatite phases prepared by a multi-sample loading device. Materials Characterization, 135, 1-7. https://doi.org/10.1016/j.matchar.2017.11.009

Kouchehbagh, N.A. (2012). Preparation, characterization, and stability evaluation of astaxanthin nanodispersions. Corpus ID: 104180067

Kolb, L., & Ferrer-Bruker, S. J. (2023). Atopic dermatitis. In StatPearls [Internet]. StatPearls Publishing. Available from https://www.ncbi.nlm.nih.gov/books/NBK448071/ [Accessed 20 August 2024].

Kumar, P., Sharma, D. K., & Ashawat, M. S. (2022). Topical creams of piperine-loaded lipid nanocarriers for the management of atopic dermatitis: Development, characterization, and in vivo investigation using BALB/C mice model. Journal of Liposome Research, 32(1), 62-73. https://doi.org/10.1080/08982104.2021.1880436

Kumar, A., Pathak, K., & Bali, V. (2012). Ultra-adaptable nanovesicular systems: A carrier for systemic delivery of therapeutic agents. Drug Discovery Today, 17(21-22), 1233-1241. https://doi.org/10.1016/j.drudis.2012.06.013

Kumar, L., Verma, S., Singh, K., Prasad, D. N., & Jain, A. K. (2016). Ethanol-based vesicular carriers in transdermal drug delivery: Nanoethosomes and transethosomes in focus. NanoWorld Journal, 2(3). https://doi.org/10.17756/nwj.2016-030

Kunasekaran, V., & Krishnamoorthy, K. (2016). Formulation and evaluation of nanoscale solid lipid particles containing a hydrophilic drug-rasagiline mesylate. Journal of Applied Pharmaceutical Science, 6, 044-050. https://doi.org/10.7324/JAPS.2016.60507.

Lee, Y. S., Jeon, S. H., Ham, H. J., Lee, H. P., Song, M. J., & Hong, J. T. (2020). Improved anti-inflammatory effects of liposomal astaxanthin on a phthalic anhydride-induced atopic dermatitis model. Frontiers in Immunology, 11. https://doi.org/10.3389/fimmu.2020.565285

Li, J., Wang, X., Zhang, T., Wang, C., Huang, Z., Luo, X., & Deng, Y. (2015). A review on phospholipids and their main applications in drug delivery systems. Asian Journal of Pharmaceutical Sciences, 10(2), 81-98. https://doi.org/10.1016/j.ajps.2014.09.004

Liu, D., Hu, H., Lin, Z., Chen, D., Zhu, Y., Hou, S., & Shi, X. (2013). Quercetin deformable liposome: preparation and efficacy against ultraviolet b-induced skin damages in vitro and in vivo. Journal of Photochemistry and Photobiology B: Biology, 127, 8-17. https://doi.org/10.1016/j.jphotobiol.2013.07.014

Liu, P., Chen, G., & Zhang, J. (2022). A review of liposomes as a drug delivery system: Current status of approved products, regulatory environments, and future perspectives. Molecules, 27(4). https://doi.org/10.3390/molecules27041372

Maherani, B., Arab-Tehrany, E., Mozafari, M. R., Gaiani, C., & Linder, M. (2011). Liposomes: A review of manufacturing techniques and targeting strategies. Current Nanoscience, 7(3), 436-452. https://doi.org/10.2174/157341311795542453

Marianecci, C., Rinaldi, F., Mastriota, M., Pieretti, S., Trapasso, E., Paolino, D., & Carafa, M. (2012). Anti-inflammatory activity of novel ammonium glycyrrhizinate/niosomes delivery system: Human and murine models. Journal of Controlled Release, 164(1), 17-25. https://doi.org/10.1016/j.jconrel.2012.09.018

Marques, M. P., Varela, C., Mendonça, L., & Cabral, C. (2023). Nanotechnology-based topical delivery of natural products for the management of atopic dermatitis. Pharmaceutics, 15(6). https://doi.org/10.3390/pharmaceutics15061724

Mascarenhas-Melo, F., Carvalho, A., Gonçalves, M. B. S., Paiva-Santos, A. C., & Veiga, F. (2022). Nanocarriers for the topical treatment of psoriasis - pathophysiology, conventional treatments, nanotechnology, regulatory, and toxicology. European Journal of Pharmaceutics and Biopharmaceutics, 176, 95-107. https://doi.org/10.1016/j.ejpb.2022.05.012

Mayangsari, F., Surini, S., & Iswandana, R. (2022). Development of transfersomal emulgel to enhance the permeation of berberine chloride for transdermal delivery. Journal of Applied Pharmaceutical Science, 12(2), 48-55. https://doi.org/10.7324/JAPS.2021.120205

Meesa, R., & Srinivas, A. (2016). Ethosomes as novel drug delivery carriers - A review. ResearchGate. Available from https://www.researchgate.net/publication/330727571 [Accessed 01 August 2024].

Mishra, K. K., Kaur, C. D., Verma, S., Sahu, A. K., Dash, D. K., Kashyap, P., & Mishra, S. P. (2019). Transethosomes and nanoethosomes: Recent approach on transdermal drug delivery system. In IntechOpen eBooks. https://doi.org/10.5772/intechopen.81152

Msomi, N. Z., & Simelane, M. B. C. (2019). Herbal Medicine. Herbal Medicine. IntechOpen. https://doi.org/10.5772/intechopen.72816

Nadaf, S., & Killedar, S. (2021). Ultradeformable liposomal nanostructures: Role in transdermal delivery of therapeutics. 491-516. https://doi.org/10.1016/B978-0-12-820569-3.00018-9.

Nangare, S., Bhatane, D., Mali, R., & Shitole, M. (2021). Development of a novel freeze-dried mulberry leaf extract-based transfersome gel. Turkish Journal of Pharmaceutical Sciences, 18(1), 44-55. https://doi.org/10.4274/tjps.galenos.2019.98624

Nayak, D., & Tippavajhala, V. K. (2021). A comprehensive review on preparation, evaluation, and applications of deformable liposomes. Iranian Journal of Pharmaceutical Research, 20(1), 186-205. https://doi.org/10.22037/ijpr.2020.112878.13997

Negi, P., Sharma, I., Hemrajani, C., Rathore, C., Bisht, A., Raza, K., & Katare, O. P. (2019). Thymoquinone-loaded lipid vesicles: A promising nanomedicine for psoriasis. BMC Complementary and Alternative Medicine, 19(1). https://doi.org/10.1186/s12906-019-2675-5

Nugraha, M. W., Iswandana, R., & Jufri, M. (2020). Preparation, characterization, and formulation of solid lipid nanoparticles lotion from mulberry roots (Morus alba L.). International Journal of Applied Pharmaceutics, 12(Special Issue 1), 182-186. https://doi.org/10.22159/ijap.2020.v12s1.FF041

Pandey, R., Bhairam, M., Shukla, S., & Gidwani, B. (2021). Colloidal and vesicular delivery system for herbal bioactive constituents. DARU Journal of Pharmaceutical Sciences, 29, 415 - 438. https://doi.org/10.1007/s40199-021-00403-x.

Priprem, A., Janpim, K., Nualkaew, S., & Mahakunakorn, P. (2016). Topical niosome gel of Zingiber cassumunar Roxb. Extract for anti-inflammatory activity: enhanced skin permeation and stability of compound D. AAPS PharmSciTech, 17(3), 631-639. https://doi.org/10.1208/s12249-015-0376-z

Priya, M. D. K., Kumar, V., Damini, V. K., Eswar, K., Reddy, K. R., Raj, S. B., & Sucharitha, P. (2020). Somes: A review on composition, formulation methods, and evaluations of different types of “somes” drug delivery system. International Journal of Applied Pharmaceutics, 12(6), 7-18. https://doi.org/10.22159/ijap.2020v12i6.38996

Ramadon, D., McCrudden, M. T. C., Courtenay, A. J., & Donnelly, R. F. (2022). Enhancement strategies for transdermal drug delivery systems: Current trends and applications. Drug Delivery and Translational Research, 12(4), 758-791. https://doi.org/10.1007/s13346-021-00909-6

Raut, J. S., & Karuppayil, S. M. (2014). A status review on the medicinal properties of essential oils. Industrial Crops and Products, 62, 250-264. https://doi.org/10.1016/j.indcrop.2014.05.055

Ross, M. H., & Pawlina, W. (2011). Histology: A text and atlas: With correlated cell and molecular biology (6th ed.). Lip Pincott Williams & Wilkins.

Sah, A., & Suresh, P. (2017). Loteprednol etabonate nanoparticles: Optimization via box-behnken design response surface methodology and physicochemical characterization. Current Drug Delivery, 14 5, 676-689. https://doi.org/10.2174/1567201813666160801125235.

Sahu, R., Sharma, N., Kumar, A., & Sahu, S. (2023). Formulation and evaluation of gel containing Nigella sativa seed extract-loaded transferosomes for effective treatment of psoriasis. Current Nanomaterials, 9. https://doi.org/10.2174/0124054615251738231211080244

Scanlon, V. C., & Sanders, T. (2007). Essentials of anatomy and physiology. F. A. Davis Company.

Schneider, M., Stracke, F., Hansen, S., & Schaefer, U. F. (2009). Nanoparticles and their interactions with the dermal barrier. Dermatoendocrinology, 1(4), 197-206. https://doi.org/10.4161/derm.1.4.9501

Sguizzato, M., Esposito, E., & Cortesi, R. (2021). Lipid‐based nanosystems as a tool to overcome skin barrier. International Journal of Molecular Sciences, 22(15). https://doi.org/10.3390/ijms22158319

Shaji, J., & Bajaj, R. (2018). Transethosomes: A new prospect for enhanced transdermal delivery. International Journal of Pharmaceutical Sciences and Research, 9(7), 2681-2685. https://doi.org/10.13040/IJPSR.0975-8232.9(7).2681-85

Sharma, K., & Sahoo, J. (2016). Novel drug delivery systems for herbal drugs. https://doi.org/10.28933/SHARMA-AND-SAHOO-JHMR-0310-2016.

Sharma, A., Yadav, T., Tickoo, O., Sudhakar, K., Pandey, N., Gupta, P., Charyulu, N., Wafa, A., Rana, P., & Monika. (2024). Transfersomes as a Surfactant-based Ultradeformable Liposome. BIO Web of Conferences. https://doi.org/10.1051/bioconf/20248601021.

Singh, N., Shaikh, A. M., Gupta, P., Kovács, B., Abuzinadah, M. F., Ahmad, A., Goel, R., Singh, S., & Vinayak, C. (2024). Nanophytosomal gel of Heydotis corymbosa (L.) extract against psoriasis: Characterisation, in vitro and in vivo biological activity. Pharmaceuticals, 17(2). https://doi.org/10.3390/ph17020213

Sudhakar, K., Fuloria, S., Subramaniyan, V., Sathasivam, K. V., Azad, A. K., Swain, S. S., Sekar, M., Karupiah, S., Porwal, O., Sahoo, A., Meenakshi, D. U., Sharma, V. K., Jain, S., Charyulu, R. N., & Fuloria, N. K. (2021). Ultraflexible liposome nanocargo as a dermal and transdermal drug delivery system. Nanomaterials, 11(10). https://doi.org/10.3390/nano11102557

Sukmaningrum, N., Sari, L. O. R. K., & Irawan, E. D. (2017). Optimasi konsentrasi etil selulosa dan lama pengadukan dalam preparasi microspheres metformin hidroklorida. Indonesian Journal of Pharmaceutical Science and Technology, 4(3), 95–104.

Sultana, B., Rajak, P., Bhuyan, B., Patra, E., Baruah, A., & Paul, D. (2018). Therapeutic potential of herbal ethosome in applied nanotechnology. Corpus ID: 221991647

Surini, S., Arnedy, A. R., & Iswandana, R. (2019). Development of ethosome containing bitter melon (Momordica charantia Linn.) fruit fraction and in vitro skin penetration. Pharmacognosy Journal, 11(6), 1242-1251. https://doi.org/10.5530/pj.2019.11.193

Tangri, P., & Khurana, S. (2011). Niosomes: formulation and evaluation. Proceedings. Retrieved from https://api.semanticscholar.org/CorpusID:33500477

Tortora, G. J., & Derrickson, B. (2012). The Essentials of Anatomy and Physiology. Retrieved from www.wiley.com/go/citizenship

Uchechi, O., Ogbonna, J. D. N., & Attama, A. A. (2014). Nanoparticles For dermal and transdermal drug delivery. Application of Nanotechnology in Drug Delivery. InTech. https://doi.org/10.5772/58672

Urban, K., Chu, S., Giesey, R. L., Mehrmal, S., Uppal, P., Delost, M. E., & Delost, G. R. (2021). Burden of skin disease and associated socioeconomic status in Asia: A cross-sectional analysis from the global burden of disease study 1990-2017. JAAD International, 2, 40-50. https://doi.org/10.1016/j.jdin.2020.10.006

Wang, Y., Zheng, Y., Zhang, L., Wang, Q., & Zhang, D. (2013). Stability of nanosuspensions in drug delivery. Journal of Controlled Release: Official Journal of the Controlled Release Society, 172 3, 1126-41 . https://doi.org/10.1016/j.jconrel.2013.08.006.

Walsh, T. R., Efthimiou, J., & Dréno, B. (2016). Systematic review of antibiotic resistance in acne: An increasing topical and oral threat. The Lancet Infectious Diseases, 16(3), e23–e33. https://doi.org/10.1016/S1473-3099(15)00527-7

Yu, Z., Lv, H., Han, G., & Ma, K. (2016). Ethosomes loaded with cryptotanshinone for acne treatment through topical gel formulation. PLOS ONE, 11(7). https://doi.org/10.1371/journal.pone.0159967

Zhang, Y., Xia, Q., Li, Y., He, Z., Li, Z., Guo, T., Wu, Z., & Feng, N. (2019). CD44 assists the topical anti-psoriatic efficacy of curcumin-loaded hyaluronan-modified ethosomes: A new strategy for clustering drug in inflammatory skin. Theranostics, 9(1), 48-64. https://doi.org/10.7150/thno.29715

Zhang, Z., Tsai, P. C., Ramezanli, T., & Michniak-Kohn, B. B. (2013). Polymeric nanoparticles-based topical delivery systems for the treatment of dermatological diseases. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 5(3), 205-218. https://doi.org/10.1002/wnan.1211

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