Abstract
In 2022, Indonesia experienced a public health crisis involving acute kidney failure in children, traced to paracetamol syrup contaminated with ethylene glycol and diethylene glycol. This underscores the urgent need for safer antipyretic alternatives. This study investigates the antipyretic potential of transdermal patches formulated with ethanol extract of water hyacinth (Eichhornia crassipes) leaves sourced from Srandakan, Bantul, Yogyakarta. Extract concentrations of 0.8%, 1.0%, and 1.2% were tested, alongside a negative control (no extract) and a positive control (paracetamol). The patches underwent evaluations for organoleptic properties, weight uniformity (0.41±0.02 to 0.52±0.02 g), thickness (0.36±0.03 to 0.41±0.03 mm), water absorption (5.95%±0.04 to 17.45%±0.04), folding endurance (all >300 times), and pH (4.05±0.03 to 4.20±0.04). Antipyretic activity was assessed in vivo using Wistar rats. The 1.2% extract patch (F3) showed a temperature reduction of 57.45±14.31% at 180 minutes, while paracetamol achieved 74.07±11.38%. Although paracetamol showed greater efficacy, the extract patch acted faster. Both paracetamol and extract patch were statistically significant compared to placebo (p
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Recommended Citation
Niswara, Anggita Kamalia; Kusrinanti, Nabillah Ainun; Firdaus, Rizqi Amalia; and Ikhsanudin, Azis
(2025)
"Utilizing Water Hyacinth (Eichhornia crassipes) from Srandakan Bantul, Indonesia for ‘Bright Fever Patch’ as an Alternative Children’s Fever Therapy,"
Pharmaceutical Sciences and Research: Vol. 11:
No.
3, Article 5.
DOI: 10.7454/psr.v11i3.1344
Available at:
https://scholarhub.ui.ac.id/psr/vol11/iss3/5
Included in
Natural Products Chemistry and Pharmacognosy Commons, Other Pharmacy and Pharmaceutical Sciences Commons, Pharmaceutics and Drug Design Commons
