"Anthocyanin-Rich Extract from Purple Sweet Potatoes" by Nia Kurnianingsih, Oktivani Adelathifa Rahma et al.
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Abstract

Stress-induced inflammation and oxidative stress mechanisms thus plant bioactive compounds as anti-inflammation and antioxidants are placed as novel strategies to resist the adverse effects of stress. Purple sweet potatoes (PSP) as a rich source of macronutrients and anthocyanin showed health benefits as neuroprotective and metabolic diseases. However, limited research explored the effect of PSP extract on stressed animal models. This study aimed to evaluate the bioactive compound analysis of PSP and the effect on body weight gain (BW), visceral fat (VF), and interleukin-10 (IL-10) of stressed model mice. Adult male BALB/c mice (6-8 weeks) were divided into control (CTRL), and stress (STR), stress+anthocyanin-rich extract (ANC) of PSP dose 10, 20, and 40 mg/kgBW. Stress was exposed as restraint stress for 2 hours/day for 14 days. The ANC was administered once a day orally. The IL-10 was measured by enzyme-linked immunosorbent assay (ELISA). Qualitative plant compound analysis showed the presence of flavonoids, alkaloids, phenolics, glycosides, and tannins in PSP extract. The PSP extract also contains a high level of total anthocyanin, 2468.9 ± 159.38 mg/l, and high antioxidant activity. This study observed tendencies to decrease BW and VF following ANC dose of 10 mg/kgBW treatment. The administration of ANC significantly increased the level of circulatory IL-10 cytokine. In conclusion, an anthocyanin-rich extract of PSP modified BW, VF, and IL-10 levels of restraint-stressed model mice.

References

Adamo, L., Rocha-Resende, C., Lin, C. Y., Evans, S., Williams, J., Dun, H., Li, W., Mpoy, C., Andhey, P. S., Rogers, B. E., Lavine, K., Kreisel, D., Artyomov, M., Randolph, G. J., & Mann, D. L. (2020). Myocardial B cells are a subset of circulating lymphocytes with delayed transit through the heart. JCI Insight, 5(3). https://doi.org/10.1172/jci.insight.134700

Alam, F. M., Kurnianingsih, N., & Fatchiyah, F. (2022). Phytochemical analysis of purple sweet potatoes (Ipomoea batatas) roots extract from lawang and kawi mountain cultivar, East Java, Indonesia. The Journal of Experimental Life Sciences, 12(1), 17–22. https://doi.org/10.21776/ub.jels.2022.012.01.03

Arulselvan, P., Fard, M. T., Tan, W. S., Gothai, S., Fakurazi, S., Norhaizan, M. E., & Kumar, S. S. (2016). Role of antioxidants and natural products in inflammation. Oxidative Medicine and Cellular Longevity, 2016. https://doi.org/10.1155/2016/5276130

Avraham, S., Abu-Sharki, S., Shofti, R., Haas, T., Korin, B., Kalfon, R., Friedman, T., Shiran, A., Saliba, W., Shaked, Y., & Aronheim, A. (2020). Early cardiac remodeling promotes tumor growth and metastasis. Circulation, 142(7), 670–683. https://doi.org/10.1161/CIRCULATIONAHA.120.046471

Bechmann, N., Berger, I., Bornstein, S. R., & Steenblock, C. (2021). Adrenal medulla development and medullary-cortical interactions. Molecular and Cellular Endocrinology, 528(November 2020), 111258. https://doi.org/10.1016/j.mce.2021.111258

Bonomini, F. (2023). Antioxidants and obesity. International Journal of Molecular Sciences, 24(16), 2–4. https://doi.org/10.3390/ijms241612832

Brown, C. R. (2005). Antioxidants in potato. American Journal of Potato Research, 82(2), 163–172. https://doi.org/10.1007/BF02853654

Carnell, S., Benson, L., Papantoni, A., Chen, L., Huo, Y., Wang, Z., Peterson, B. S., & Geliebter, A. (2022). Obesity and acute stress modulate appetite and neural responses in food word reactivity task. PLoS ONE, 17(9 September), 1–28. https://doi.org/10.1371/journal.pone.0271915

Chen, H. J. C., Yip, T., Lee, J. K., Juliani, J., Sernia, C., Hill, A. F., Lavidis, N. A., & Spiers, J. G. (2020). Restraint stress alters expression of glucocorticoid bioavailability mediators, suppresses NRF2, and promotes oxidative stress in liver tissue. Antioxidants, 9(9), 1–20. https://doi.org/10.3390/antiox9090853

Chusyd, D. E., Wang, D., Huffman, D. M., & Nagy, T. R. (2016). Relationships between rodent white adipose fat pads and human white adipose fat depots. Frontiers in Nutrition, 3(April). https://doi.org/10.3389/fnut.2016.00010

Colak, E., & Pap, D. (2021). The role of oxidative stress in the development of obesity and obesity-related metabolic disorders. Journal of Medical Biochemistry, 40(1), 1–9. https://doi.org/10.5937/jomb0-24652

Colitti, M., Stefanon, B., Gabai, G., Gelain, M. E., & Bonsembiante, F. (2019). Oxidative stress and nutraceuticals in the modulation of the immune function: Current knowledge in animals of veterinary interest. Antioxidants, 8(1). https://doi.org/10.3390/antiox8010028

Deledda, A., Annunziata, G., Tenore, G. C., Palmas, V., Manzin, A., & Velluzzi, F. (2021). Diet-derived antioxidants and their role in inflammation, obesity and gut microbiota modulation. Antioxidants, 10(5), 1–22. https://doi.org/10.3390/antiox10050708

Eik-Nes, T. T., Tokatlian, A., Raman, J., Spirou, D., & Kvaløy, K. (2022). Depression, anxiety, and psychosocial stressors across BMI classes: A Norwegian population study - The HUNT Study. Frontiers in Endocrinology, 13(August), 1–11. https://doi.org/10.3389/fendo.2022.886148

Fatchiyah, F., Safitri, A., Palis, C. N., Sari, D. R. T., Suyanto, E., Fajriani, S., Kurnianingsih, N., Nugraha, Y., Sitaresmi, T., Kusbiantoro, B., & Ketudat-Cairns, J. R. (2023). Bioactive compound profile and their biological activities of endogenous black rice from Java and East Nusa Tenggara. CYTA - Journal of Food, 21(1), 159–170. https://doi.org/10.1080/19476337.2023.2173306

Gianotti, L., Belcastro, S., D’Agnano, S., & Tassone, F. (2021). The stress axis in obesity and diabetes mellitus: An update. Endocrines, 2(3), 334–347. https://doi.org/10.3390/endocrines2030031

Gorlova, A., Svirin, E., Pavlov, D., Cespuglio, R., Proshin, A., Schroeter, C. A., Lesch, K. P., & Strekalova, T. (2023). Understanding the role of oxidative stress, neuroinflammation and abnormal myelination in excessive aggression associated with depression: Recent input from mechanistic studies. International Journal of Molecular Sciences, 24(2). https://doi.org/10.3390/ijms24020915

Higgs, J. A., Quinn, A. P., Seely, K. D., Richards, Z., Mortensen, S. P., Crandall, C. S., & Brooks, A. E. (2022). Pathophysiological link between insulin resistance and adrenal incidentalomas. International Journal of Molecular Sciences, 23(8). https://doi.org/10.3390/ijms23084340

Hill, D., Conner, M., Clancy, F., Moss, R., Wilding, S., Bristow, M., & O’Connor, D. B. (2022). Stress and eating behaviours in healthy adults: A systematic review and meta-analysis. Health Psychology Review, 16(2), 280–304. https://doi.org/10.1080/17437199.2021.1923406

Jamal, M. A., Ahmed, A. M., Tahir, M., Ashraf, M., Sattar, A., Ghafoor, A., Munir, S., Ahmed, I., Hussain, M., & Riaz, A. (2019). Safety and efficacy of ketamine xylazine along with atropine anesthesia in BALB/c mice. Brazilian Journal of Pharmaceutical Sciences, 55, 1–6. https://doi.org/10.1590/s2175-97902019000317231

Karri, S., Sharma, S., Hatware, K., & Patil, K. (2019). Natural anti-obesity agents and their therapeutic role in management of obesity: A future trend perspective. Biomedicine and Pharmacotherapy, 110 (November 2018), 224–238. https://doi.org/10.1016/j.biopha.2018.11.076

Keaton, S. A., Arnetz, J., Jamil, H., Dhalimi, A., Stemmer, P. M., Ruden, D. M., Yamin, J., Achtyes, E., Smart, L. A., Brundin, L., & Arnetz, B. B. (2021). IL-10: A possible immunobiological component of positive mental health in refugees. Comprehensive Psychoneuroendocrinology, 8, 100097. https://doi.org/10.1016/j.cpnec.2021.100097

Kumar, R., Rizvi, M. R., & Saraswat, S. (2017). Obesity and stress: A contingent paralysis. International Journal of Preventive Medicine, 8, 1–9. https://doi.org/10.4103/ijpvm.IJPVM

Kurnianingsih, N., Artamevia, D., Hasanah, D., Harbiyanti, N. T., & Ratnawati, R. (2024). Alterations in blood profiles and spleen tissue following purple sweet potato anthocyanin extract treatment in restraint-stressed mice. Journal of Tropical Life Science, 14(1), 195–204. https://doi.org/10.11594/jtls.14.01.19.N

Kurnianingsih, N., Artamevia, D., Winarta, A. K., & Wulandari, A. P. (2023). Modifying effect of anthocyanin from purple sweet potatoes on visceral fat tissue inflammation and liver oxidative stress in psychological stress-induced mice. Journal of Tropical Life Science, 13(2), 393–398. https://doi.org/10.11594/jtls.13.02.18.N

Kurnianingsih, N., Hakim, A. R., Salsabila, D., Fahanani, A. F., Harbiyanti, N. T., & Ratnawati, R. (2024). Anthocyanin extract from purple sweet potato improving neurotransmitter and locomotor in chronic stressed-mice. Iranian Journal of Veterinary Medicine, 18(3), 333–344. https://doi.org/10.32598/ijvm.18.3.1005405

Kurnianingsih, N., Ratnawati, R., Nazwar, T. A., Ali, M., & Fatchiyah, F. (2020). The behavioral effect of anthocyanin from purple sweet potatoes on prenatally stressed offspring mice. Systematic Reviews in Pharmacy, 11(10), 482–490. https://doi.org/10.31838/srp.2020.10.72

Kurnianingsih, N., Ratnawati, R., Nazwar, T., Ali, M., & Fatchiyah, F. (2021). Purple sweet potatoes from East Java of Indonesia revealed the macronutrient, anthocyanin compound and antidepressant activity candidate. Medical Archives, 75(2), 94. https://doi.org/10.5455/medarh.2021.75.94-100

Kuti, D., Winkler, Z., Horváth, K., Juhász, B., Szilvásy-Szabó, A., Fekete, C., Ferenczi, S., & Kovács, K. J. (2022). The metabolic stress response: Adaptation to acute-, repeated- and chronic challenges in mice. IScience, 25(8). https://doi.org/10.1016/j.isci.2022.104693

Li, A., Xiao, R., He, S., An, X., He, Y., Wang, C., Yin, S., Wang, B., Shi, X., & He, J. (2019). Research advances of purple sweet potato anthocyanins: Extraction, identification, stability, bioactivity, application, and biotransformation. Molecules, 24(21). https://doi.org/10.3390/molecules24213816

Lim., S. (2012). Anthocyanin-Enriched Purple Sweey Potato For Colon Cancer Prevention. In kansas state University.

Navita Herawati, E. R., Santosa, U., Sentana, S., & Ariani, D. (2020). Protective effects of anthocyanin extract from purple sweet potato (Ipomoea batatas l.) on blood mda levels, liver and renal activity, and blood pressure of hyperglycemic rats. Preventive Nutrition and Food Science, 25(4), 375–379. https://doi.org/10.3746/PNF.2020.25.4.375

Ngamsamer, C., Sirivarasai, J., & Sutjarit, N. (2022). The benefits of anthocyanins against obesity-induced inflammation. Biomolecules, 12(6). https://doi.org/10.3390/biom12060852

Ramírez-Moreno, E., Arias-Rico, J., Jiménez-Sánchez, R. C., Estrada-Luna, D., Jiménez-Osorio, A. S., Zafra-Rojas, Q. Y., Ariza-Ortega, J. A., Flores-Chávez, O. R., Morales-Castillejos, L., & Sandoval-Gallegos, E. M. (2022). Role of bioactive compounds in obesity: metabolic mechanism focused on inflammation. Foods, 11(9), 1–23. https://doi.org/10.3390/foods11091232

Ramos-González, E. J., Bitzer-Quintero, O. K., Ortiz, G., Hernández-Cruz, J. J., & Ramírez-Jirano, L. J. (2021). Relationship between inflammation and oxidative stress and its effect on multiple sclerosis. Neurologia, 39(3), 292-301. https://doi.org/10.1016/j.nrl.2021.10.003

Reddin, C., Murphy, R., Hankey, G. J., Judge, C., Xavier, D., Rosengren, A., Ferguson, J., Alvarez-Iglesias, A., Oveisgharan, S., Iversen, H. K., Lanas, F., Al-Hussein, F., Członkowska, A., Oguz, A., McDermott, C., Pogosova, N., Málaga, G., Langhorne, P., Wang, X., … O’Donnell, M. (2022). Association of psychosocial stress with risk of acute stroke. JAMA Network Open, 5(12), E2244836. https://doi.org/10.1001/jamanetworkopen.2022.44836

Reyhanditya, D., Hikmawati, V. F., Kurnianingsih, N., & Fatchiyah, F. (2022). Restraint stress impacts on behavioral changes and adrenal and kidney tissue histopathology of adult mice. Jurnal Kedokteran Brawijaya, 32(1), 1–7. https://doi.org/10.21776/ub.jkb.2022.032.01.1

Riffer, F., Sprung, M., Münch, H., Kaiser, E., Streibl, L., Heneis, K., & Kautzky-Willer, A. (2020). Relationship between psychological stress and metabolism in morbidly obese individuals. Wiener Klinische Wochenschrift, 132(5–6), 139–149. https://doi.org/10.1007/s00508-019-01583-y

Roemmich, J. N., Balantekin, M. J. L. K. N., Feda, D. M., & Dorn, J. (2014). Stress, behavior, and biology: risk factors for cardiovascular diseases in youth. Exercise and Sport Sciences Reviews, 42(2), 145–152. https://doi.org/10.1002/hep.30150.Ductular

Roque, S., Correia-Neves, M., Mesquita, A. R., Palha, J. A., & Sousa, N. (2009). Interleukin-10: A key cytokine in depression? Cardiovascular Psychiatry and Neurology, 2009, 1–5. https://doi.org/10.1155/2009/187894

Rukmana, T. I., Kurniadi, F. N., & Harmita, H. (2023). Synthesis of ferrous fumarate from indonesian iron sand and in vivo body weight gain test in rats. Pharmaceutical Sciences and Research, 10(1), 38–47. https://doi.org/https://doi.org/10.7454/psr.v10i1.1301

Safitri, A., Fatchiyah, F., Ratih, D., Sari, T., & Roosdiana, A. (2020). Phytochemical screening, in vitro anti-oxidant activity, and in silico anti-diabetic activity of aqueous extracts of Ruellia tuberosa L. Journal of Applied Pharmaceutical Science, 10(3), 101–108. https://doi.org/10.7324/japs.2020.103013

Salehi, B., Sharifi-Rad, J., Cappellini, F., Reiner, Z., Zorzan, D., Imran, M., Sener, B., Kilic, M., El-Shazly, M., Fahmy, N. M., Al-Sayed, E., Martorell, M., Tonelli, C., Petroni, K., Docea, A. O., Calina, D., & Maroyi, A. (2020). The therapeutic potential of anthocyanins: current approaches based on their molecular mechanism of action. Frontiers in Pharmacology, 11(August), 1–20. https://doi.org/10.3389/fphar.2020.01300

Sendangratri, Handayani, R., & Elya, B. (2019). Inhibitory effects of different varieties of sweet potato (Ipomoea batatas L.) tubers extracts on lipoxygenase activity. Pharmacognosy Journal, 11(6), 1195–1198. https://doi.org/10.5530/pj.2019.11.185

Speer, H., Cunha, N. M. D., Alexopoulos, N. I., Mckune, A. J., & Naumovski, N. (2020). Anthocyanins and human health — A focus on oxidative stress, inflammation and disease. Antioxidants, 9(366).

Steptoe, A., & Frank, P. (2023). Obesity and psychological distress. Philosophical Transactions of the Royal Society B: Biological Sciences, 378(1888). https://doi.org/10.1098/rstb.2022.0225

Tang, C., Han, J., Chen, D., Zong, S., Liu, J., Kan, J., Qian, C., & Jin, C. (2023). Recent advances on the biological activities of purple sweet potato anthocyanins. Food Bioscience, 53(June 2023). https://doi.org/10.1016/j.fbio.2023.102670

Woo, S. H., Kim, J. P., Park, J. J., Chung, P. S., Lee, S. H., & Jeong, H. S. (2013). Autologous platelet-poor plasma gel for injection laryngoplasty. Yonsei Medical Journal, 54(6), 1516–1523. https://doi.org/10.3349/ymj.2013.54.6.1516

Yildiz, E., Guldas, M., Ellergezen, P., Acar, A. G., & Gurbuz, O. (2021). Obesity-associated pathways of anthocyanins. Food Sci Technol, Campinas, 41(Suppl.1), 1–13. https://doi.org/10.1590/fst.39119

Zhang, D., Wei, Y., Huang, Q., Chen, Y., Zeng, K., Yang, W., Chen, J., & Chen, J. (2022). Important hormones regulating lipid metabolism. Molecules, 27(20), 1–20. https://doi.org/10.3390/molecules27207052

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