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Abstract

Antibacterial activity tests of quinazolin-4-one derivates: 1-[(6-nitroquinazolin-4one-2-yl)methyl]piridin-1-ium bromide (1), 1-[(6-aminoquinazolin-4-on-2-yl)methyl] piridin-1-um bromide (2), 2-bromomethylquinazolin-4-one (3) and 2-bromomethyl-6nitroquinazolin-4-one(4) with trimethoprim (5) as a positive standard were conducted. The antibacterial activity tests were carried out using disc diffusion method againts E.coli, S.aureus and S.thyposa, and determination of minimum inhibitory concentration (MIC). The results showed that compounds 1 and 2 are inactive as antibacterial, whereas compounds 3 and 4 are active.The activities to E.coli were ¼ times the activity of trimethoprim (MIC : 5 x 102 µg/ml compared to 1.25 x 102 µg/ml ). The activity to S. typhosa were ½-1 times the activity of trimethoprim (MIC: 2.5 and 1.25x102 µg/ml compared to 1.25x102 µg/ml); but they are not active to S. aureus. Trimethoprim active to S. aureus with MIC : 0.62 x102 µg/ ml.

Bahasa Abstract

Telah dilakukan uji aktivitas antibakteri dari senyawa turunan kuinazolin-4-on: 1-[(6-nitrokuinazolin-4-on-2-il)metil]piridin-1-ium bromida (1), 1-[(6-aminokuinazolin-4-on-2-il)metil]piridin-1-ium bromida (2), 2-bromometilkuinazolin-4-on (3) dan 2-bromometil-6-nitrokuinazolin-4-on (4) dengan trimetoprim (5) sebagai standar positif. Uji aktivitas antibakteri dilakukan dengan metoda difusi cakram terhadap E. coli, S. thyposa dan S. aureus, dan menentukan kadar hambat minimal (KHM). Hasil penelitian menunjukkan bahwa senyawa 1 dan 2 tidak aktif sebagai antibakteri, sedangkan senyawa 3 dan 4 aktif. Aktivitas pada E. coli ¼ kali aktivitas trimetoprim (KHM: 5 x102 µg/ml dibanding 1,25 x102 µg/ml). Aktivitas pada S. typhosa ½-1 kali aktivitas trimetoprim (KHM berturut-turut: 2,5 dan 1,25 x102 µg/ml dibanding 1,25 x102 µg/ml); tetapi tidak aktif pada S. aureus. Trimetoprim aktif pada S. aureus dengan KHM: 0,62 x102 µg/ml.

References

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