•  
  •  
 

Indonesian Journal of Medical Chemistry and Bioinformatics

Abstract

Coronavirus disease 2019 (COVID-19) is a new disease caused by a novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The disease has several symptoms from mild to severe and could lead to death for comorbidities and the elderly. Therefore, the infections and mortality cases keep growing day by day, moreover many authorities are trying to suppress it by applying several health protocols, including medicines. Several studies were conducted on drug discovery from plants to cure the disease. The article aimed to do a narrative review about the prospect of JAMU becoming an alternative medicine to cure COVID-19 by mapping the literature deposited on PubMed which reported medicinal plants as an alternative medicine for COVID-19 by using a text mining program. There are approximately 30,191 articles on PUBMED related to COVID-19 and medicine. Medicinal plants with antiviral and anti-inflammatory activities are the best plants for COVID-19. JAMU, an Indonesian traditional medicine, has an outstanding possibility to be applied in the COVID-19 strategy to recover patients and prevent infections.

Bahasa Abstract

Penyakit virus corona 2019 (COVID-19) adalah penyakit baru yang disebabkan oleh virus corona baru, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Penyakit ini memiliki beberapa gejala mulai dari ringan hingga berat dan dapat menyebabkan kematian bagi penyakit penyerta dan lansia. Oleh karena itu, kasus infeksi dan kematian terus bertambah dari hari ke hari, bahkan banyak pihak yang berupaya menekannya dengan menerapkan beberapa protokol kesehatan, termasuk obat-obatan. Beberapa penelitian dilakukan mengenai penemuan obat dari tumbuhan untuk menyembuhkan penyakit tersebut. Artikel ini bertujuan untuk melakukan tinjauan naratif mengenai prospek JAMU menjadi pengobatan alternatif penyembuhan COVID-19 dengan memetakan literatur yang ada di PubMed yang melaporkan tanaman obat sebagai pengobatan alternatif COVID-19 dengan menggunakan program text mining. Terdapat kurang lebih 30.191 artikel di PUBMED terkait COVID-19 dan obat-obatan. Tanaman obat dengan aktivitas antivirus dan antiinflamasi merupakan tanaman terbaik untuk COVID-19. JAMU, obat tradisional Indonesia, memiliki kemungkinan luar biasa untuk diterapkan dalam strategi COVID-19 untuk memulihkan pasien dan mencegah infeksi. data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABQAAAAUCAQAAAAngNWGAAAA/0lEQVR4AYXNMSiEcRyA4cfmGHQbCZIipkuxnJgMStlMNmeyD2dwmc8+sZgxYJd9ErIZFHUyYYD7fkr6l4/rnvmtl7+KitrqV/fq2Y5eLY3Z9S48eRLe7BmVZ9qhTLhQ0algzZWQOVKSsCF8OjAnwbxDTWFDUhPK/jMr1H6HE/IqRky2DyvCefuwItwZzodVoYRiLqMkVCXrwpJ9twZ+sgfDYEFYl8wIWxZ9uFf7zkallxlJh4YrLGsKjZRx7VGHhLqwgFUN45DGdb8MeXGpgB4ABZdeDcpZEY51A+hyLKz4S1W4MQWm3AibWtgWmk6dyISa1pSdyWTOlLXVp0+eL9D/ZPfBTNanAAAAAElFTkSuQmCC

References

  1. Wu, D.; Wu, T.; Liu, Q.; Yang, Z. The SARS-CoV-2 Outtbreak: What we know. International Journal of Infectious Diseases, 2020, 94 : 44-48 https://doi.org/10.1016/j.ijid.2020.03.004
  2. Li, H.; Liu, S.; Yu, X.; Tang, S.; Tang, C. (2020). Coronavirus disease 2019 (COVID-19): current status and future perspective. International Journal of Antimicrobial Agents, 2019, 105951. https://doi.org/10.1016/j.ijantimicag.2020.105951
  3. Cunningham, A.C.; Goh, H.P.; Koh, D. Treatment of COVID-19: Old tricks for new challenges. Critical Care, 2020, 24(1), 6–7. https://doi.org/10.1186/s13054-020-2818-6
  4. Pawar, A.Y. Combating devastating COVID-19 by drug repurposing. Journal of Antimicrobial Agents (in Press), 2020, 56(2) : 105984. https://doi.org/https://doi.org/10.1016/j.ijantimicag.2020.105984
  5. Martinez, M.A. Compounds with therapeutic potential against novel respiratory 2019 coronavirus. Antimicrobial Agents and Chemotherapy, 2020, 64(5), 1–7. https://doi.org/10.1128/AAC.00399-20
  6. Phadke, M.; Saunik, S. COVID-19 treatment by repurposing drugs until the vaccine is in sight. Drug Development Research, 2020, 2, 2–4. https://doi.org/10.1002/ddr.21666
  7. Rabby, M.I.I. Current drugs with potential for treatment of covid-19: A literature review. Journal of Pharmacy and Pharmaceutical Sciences, 2020, 23(1), 58–64. https://doi.org/10.18433/jpps31002
  8. Ren, J.L.; Zhang, A.H.; Wang, X.J. Traditional Chinese Medicine for COVID- 19 treatment. Pharmacological Research, 2020, 155.
  9. Touret, F.; Lamballerie, X.De. Of Chloroquine and COVID-19. Antiviral Research, 2020, 177.
  10. Adiwijaya, I. Text mining dan knowledge discovery. Kolokium Bersama Komunitas Datamining Indonesia & Soft-Computing Indonesia, 2006, 1–9.
  11. Reuters, T. (2008). Using Bibliometrics to Support Your Selection of a Nursing Terminology Set. CIN: Computers, Informatics, Nursing, 2009, 27(2) : 91-92.
  12. Flores-Fernández, C.N.; Chávez-Hidalgo, E.; Santos, M.; Zavaleta, A.I.; Arahal, D.R. Molecular characterization of protease producing idiomarina species isolated from peruvian saline environments. Microbiology and Biotechnology Letters, 2019, 47(3), 4001–4411. https://doi.org/10.4014/mbl.1809.09001
  13. Garrido-Cardenas, J.A.; Cebrián-Carmona, J.; González-Cerón, L.; Manzano-Agugliaro, F.; Mesa-Valle, C. Analysis of global research on malaria and Plasmodium vivax. International Journal of Environmental Research and Public Health, 2019, 16(11). https://doi.org/10.3390/ijerph16111928
  14. Ortiz-Martínez, Y.; Galindo-Regino, C.; González-Hurtado, M.R.; Vanegas-Pastrana, J.J.; Valdes-Villegas, F. State of the art on Mycobacterium chimaera research: a bibliometric analysis. Journal of Hospital Infection, 2018, 100(3), e159–e160. https://doi.org/10.1016/j.jhin.2017.12.004
  15. Padros-Cuxart, R.; Riera-Quintero, C.; March-Mir, F. Bibliometrics: A publication analysis tool. CEUR Workshop Proceedings, 2016, 1567, 44–53.
  16. Ananiadou, S.; Kell, D.B.; Tsujii, J. Text mining and its potential applications in systems biology. Trends in Biotechnology, 2006, 24(12), 571–579. https://doi.org/10.1016/j.tibtech.2006.10.002
  17. Choudhuri, S. Bioinformatics for Beginners : Genes, Genomes, Molecular Evolution, Dartabases, and Analitical Tools. Elsevier Science, NL, 2014.
  18. Hidayati, W. Pengobatan dengan Plasma Pasien yang Sembuh dari COVID- 19 Dapat Menjadi Alternatif Pengobatan COVID-19. Kompasiana, 6 April 2020.
  19. Lou, J.; Tian, S. J.; Niu, S.M. Kang, X.Q.; Lian, H.X.; Zhang, L.X.; Zhang, J.J. Coronavirus disease 2019: A bibliometric analysis and review. European Review for Medical and Pharmacological Sciences, 2020, 24(6), 3411–3421. https://doi.org/10.26355/eurrev_202003_20712
  20. Şimşek Yavuz, S.; Ünal, S. Antiviral treatment of covid-19. Turkish Journal of Medical Sciences, 2020, 50(SI-1): 611–619. https://doi.org/10.3906/sag-2004-145
  21. Zhou, P.; Yang, X.L.; Wang, X.G.; Hu, B.; Zhang, L.; Zhang, W.; et al. Discovery of A Novel Coronavirus Associated with The Recent Pneumonia Outbreak in Humans and Its Potential Bat Origin. BioRxiv, 2020, 1–13.
  22. Zhu, F.; Patumcharoenpol, P.; Zhang, C.; Yang, Y.; Chan, J.; Meechai, A.; et al. Biomedical text mining and its applications in cancer research. Journal of Biomedical Informatics, 2013, 46(2), 200–211. https://doi.org/10.1016/j.jbi.2012.10.007

Download

Share

COinS