Introduction: Solitary bone plasmacytoma (SBP) is a localized neoplasms in the bone consisting of abnormal plasma cells. We herein report an unusual case of SBP that presents in mandible bone.

Case Illustration: A 57-year-old woman, with chief complaint for the lump at right jaw, which gradually increasing in size since 13 years ago. Diagnosis was based on clinical, radiological, and histopathological findings. The patient was referred for radiotherapy before surgery using 50 Gy dose of radiation for 25 times with the result of partial response, followed by hemimandibulectomy and reconstruction with free fibular flap. Complete resection in a form of hemimandibulectomy can eliminate monoclonal proteins in serum, and can reduce the progression of the disease into multiple myeloma. Patient was still in regular visits to oncology surgery clinic in RSCM, with no reccurence of disease after six months of postoperative.



  1. Afonso PD, Almeida A. Solitary Plasmacytoma of the Spine: An Usual Presentation. Am J Radiol. 2010:31(1)
  2. Bertanha F, Boufelli G, Camargo PD, Mathias A, Caiero MT, Oliveira CR,et al. Oncologic Progression of Bone Plasmacytoma to Multiple Myeloma. Brasil. CLINICS. 2006:61(2):139-46
  3. Saksena A, Mahajan N, Agarwal S, Jain S. Solitary bone plasmacytoma: An interesting case report with unusual clinico-cytological features. J Cytol. 2014;31(3):158-60
  4. Dingli D, Kapoor P, Solitary Plasmacytoma. New York. Springer. 2014;194-210
  5. Caers J, Paiva B, Zamagni E, Leleu X, Blade J, Kristinsson Y, et al. Diagnosis, treatment, and response assesment in solitary plasmacytoma: updated recommendations from a European Expert Panel. J Hemato Oncol. 2018;11(1):10
  6. Jia R, Xue L, Liang H, Gao K, Li J, Zhang Z. Surgery Combined with Radiotheraphy for the treatment of solitary plasmacytoma of the rib: a case report and review of the article. J Cariothorac Surg. 2015;10(1):4-9
  7. Kilciksiz S, Demiral AN, Celik OK, Tokatli F. Clinical and prognostic features of plasmacytoma: A multicenter study of Turkish Oncology Group-Sarcoma Working Party. Am J Hematol. 2008;83(9):702-7
  8. Li QW, Niu SQ, Wang HY, Wen G, Li YY, Xia YF, Zhang YJ. Radiotherapy Alone is Associated with Improved Outcomes Over Surgery in the Management of Solitary Plasmacytoma. APJCP. 2015;16(9):3741-5
  9. Liebross RH, Chul S, Cox JD, Weber D, Delasalle K, Alexanian R. Solitary Bone Plasmacytoma: Outcome and Prognostic Factors Following Radiotherapy. Texas. Int J Radiat Oncol Biol Phys. 1998;41(5):1063-7
  10. Bharathi MB, Malik E, Babu AR. Plasmacytoma of Head and Neck: Case Series. JCR. 2017;7(4):371-3
  11. Calvin SH, Kelvin KW. Solitary Bone Plasmacytoma. Hongkong. Can Resoir J. 2013;20(1):11
  12. Jafari D, Taheri H, Shariatzadeh H, Mazhar FN, Pahlevansabagh. Solitary Plasmacytoma of the thumb: A rare case report. Iran. MJIRI. 2009;23(3):173-6
  13. Holland J, Trenkner DA, Wasserman TH. Plasmacytoma: Treatment Results and Convertion to Myeloma. CANCER. 1992;69(6):1513-7
  14. Hughes M, Soutar R, Lucraft H, Owen R, Bird J. Guidelines on the diagnosis and management of solitary plasmacytoma of bone, extramedulary plasmacytoma and multiple solitary plasmacytoma. United Kingdom. 2009. Available from: http://academy.myeloma.org.uk
  15. Siyag A, Soni TP, Gupta AK, Sharma LM, Jakhotia N, Sharma S. Plasmacytoma of the skull-base: A Rare Tumor. J Cureus. 2018;10(1):2703
  16. Kadokura M, Tanio N, Nonaka M, Yamamoto S, Kataoka D, Kushima M, et al. A Surgical Case of Solitary Plasmacytoma of Rib Origin with Biclonal Gammopathy. Japan. Jpn J Clin Oncol. 2000;30(4):191-5
  17. Warsame R, Gertz MA, Lacy MQ, Kyle RA, Buadi F, Dingli D, et al. Trends and Outcomes of Modern Staging of Solitary Plasmacytoma of Bone. AM J Hematol. 2015;87(7):647-51
  18. Gargava A, Vaidya S, Sharma JK. Solitary Plasmacytoma of Frontal Bone: A Case Report. IJOHNS. 2018;28(10):626-30
  19. Kilciksiz S, Celik OK, Agaoglu FY, Haydaroglu A. A Review for Solitary Plasmacytoma of Bone and Extramedullary Plasmacytoma. USA. ScientificWorldJournal. 2012;1-6
  20. Guo SQ, Zhang L, Sun BC, Zhang LY, Zhang J, Wang G, et al. Prognostic factors associated with solitary plasmacytoma. Oncotarget Ther. 2013;6:1659-66
  21. Bharathi MB, Malik E, Babu AR. Plasmacytoma of Head and Neck: Case Series. JCR. 2017;7(4):371-3
  22. Jawad MU, Scully SP. Skeletal Plasmacytoma: Progression of disease and impact of local treatment; an analysis of SEER database. J Hematol Oncol:2009:2(41):1-8
  23. Madi S, Pandey V, Sharma A, Monappa V. Case of Solitary Plasmacytoma of Tibia. BMJ. 2018;1-3
  24. Kanazawa H, Shoji A, Yokoe H, Midorikawa S, Takamiya Y, Sato K. Solitary plasmacytoma of the mandible. Case report and review of the literature. J CraniomaxillofacSurg. 1993;21(5):202-6
  25. Loh, HS. A retrospective evaluation of 23 reported cases of solitary plasmacytoma of the mandible, with an additional case report. BJOMS. 1984;22(3):216–22

Included in

Surgery Commons



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.